KEGG   PATHWAY: pdf00450
Entry
pdf00450                    Pathway                                
Name
Selenocompound metabolism - Clostridioides difficile 630Derm
Class
Metabolism; Metabolism of other amino acids
Pathway map
pdf00450  Selenocompound metabolism
pdf00450

Organism
Clostridioides difficile 630Derm [GN:pdf]
Gene
CD630DERM_34410  putative pyridoxal phosphate-dependenttransferase (PLP-dependent transferase) [KO:K14155] [EC:4.4.1.13]
CD630DERM_26960  putative pyridoxal phosphate-dependenttransferase [KO:K14155] [EC:4.4.1.13]
CD630DERM_30290  malY; Bifunctional protein: cystathionine beta-lyase/repressor [KO:K14155] [EC:4.4.1.13]
CD630DERM_24840  putative aminotransferase [KO:K14155] [EC:4.4.1.13]
CD630DERM_27330  putative pyridoxal phosphate-dependenttransferase [KO:K14155] [EC:4.4.1.13]
CD630DERM_35960  putative homocysteine S-methyltransferase [KO:K00548] [EC:2.1.1.13]
CD630DERM_35770  mdeA; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
CD630DERM_36700  putative cysteine desulfurase family protein [KO:K11717] [EC:2.8.1.7 4.4.1.16]
CD630DERM_23560  trxB3; Thioredoxin reductase 3 [KO:K00384] [EC:1.8.1.9]
CD630DERM_16910  trxB; putative thioredoxin-disulfide reductase [KO:K00384] [EC:1.8.1.9]
CD630DERM_21170  trxB2; Thioredoxin reductase [KO:K00384] [EC:1.8.1.9]
CD630DERM_24960  selD; Selenide, water dikinase (Selenophosphatesynthetase) (Selenium donor protein) [KO:K01008] [EC:2.7.9.3]
CD630DERM_36420  putative selenocysteine synthase [KO:K01042] [EC:2.9.1.1]
CD630DERM_24950  selA; L-seryl-tRNA(Sec) selenium transferase(Selenocysteine synthase) (Sec synthase)(Selenocysteinyl-tRNA(Sec) synthase) [KO:K01042] [EC:2.9.1.1]
CD630DERM_35400  metG; Methionyl-tRNA synthetase (Methionine--tRNAligase) (MetRS) [KO:K01874] [EC:6.1.1.10]
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
PMID:21190829
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
PMID:19051051
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
PMID:20383543
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
PMID:17451884
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
PMID:11782468
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   
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