Phyllostomus discolor (pale spear-nosed bat): 114500037
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Entry
114500037 CDS
T07739
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
pdic
Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00350
Tyrosine metabolism
pdic00790
Folate biosynthesis
pdic01100
Metabolic pathways
pdic04728
Dopaminergic synapse
pdic04917
Prolactin signaling pathway
pdic05012
Parkinson disease
pdic05030
Cocaine addiction
pdic05031
Amphetamine addiction
pdic05034
Alcoholism
Module
pdic_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
pdic00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
114500037 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
114500037 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
114500037 (TH)
09156 Nervous system
04728 Dopaminergic synapse
114500037 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
114500037 (TH)
09165 Substance dependence
05030 Cocaine addiction
114500037 (TH)
05031 Amphetamine addiction
114500037 (TH)
05034 Alcoholism
114500037 (TH)
Enzymes [BR:
pdic01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
114500037 (TH)
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GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
114500037
NCBI-ProteinID:
XP_028372419
UniProt:
A0A6J2LZH5
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All DBs
Position
6:170353466..170360339
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AA seq
497 aa
AA seq
DB search
MPTSGAAAAAPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAAAAA
ASEPGEPLGAGACVESDGKARLSLLFTLRGAKPAPLSRALKVFETFEAQILHLETRPAPR
LRAGGPPLEYFVRCEVPGADLPALLSSVRRVAEDVRGAGESKVLWFPRKVSELDKCHHLV
TKFDPDLDLDHPGFSDQAYRQRRRLIAEIAFQHKHGDPIPRVEYTAEEIATWKEVYTTLK
GLYATHACREHLEAFALLERCSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFL
ASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASD
EEIEKLSTLYWFTVEFGLCKQDGQVKAYGAGLLSSYGELLHSLSEEPEIRPFDPDAAALQ
PYQDQTYQSVYFVSESFSDARDKLRSYASRIQRPFSVKFDPYTLAVDVLDSPQAIRRSLE
GVQDELQALSHALNALG
NT seq
1494 nt
NT seq
+upstream
nt +downstream
nt
atgcccacctctggggccgccgccgccgcgccgcaggccaagggcttccgcagggccgtg
tccgagctggacgccaagcaggccgaggccatcatgtccccgcgcttcatcgggcggagg
cagagcctcatcgaggacgcgcgcaaggagcgggagaaggcggaggcggcggcggcggcg
gcctcggagccgggagagcccctgggggctggggcgtgcgtggagagcgacggcaaggcc
cggctgagcctgctcttcaccctgcggggcgccaagcccgctccgctctcccgggccctg
aaggtgttcgagactttcgaagcccagatcctacacctggagacccggcccgccccgcgc
ctgcgggcggggggcccgcccctggagtacttcgtgcgctgtgaggtgcccggcgccgac
ctgccggccctgctcagctccgtgcgccgggtggcggaggacgtgcgtggcgccggggag
agcaaagtcctctggttccccaggaaagtctccgagctggacaagtgccaccacctggtc
accaagtttgacccggacctggacttggaccacccgggcttctcggaccaggcgtaccgc
cagcgccgcaggctgatcgccgagatcgcctttcagcacaagcacggtgaccccattccc
cgtgtggagtacacggccgaggagattgccacctggaaggaggtgtacaccaccctgaag
ggcctgtacgccacccacgcctgccgggagcacctggaggccttcgcgctgctggagcgc
tgcagcgggtaccgggaggacaacatcccccagctggaggacgtctcccgcttcctgaag
gagaggaccggcttccagctgcggccggtggccggcctgctgtccgcccgggacttcctg
gccagcctggcgttccgcgtgttccagtgcacccagtacatccggcacgcctcctcgccc
atgcactcccccgagccggactgctgccacgagctgctgggacacgtgcccatgctggcc
gaccgcaccttcgcccagttctcccaggacatcggcctagcgtccttgggagcctcggac
gaggagatcgagaagctgtccaccctgtactggttcaccgtggagttcgggctgtgcaag
caggacgggcaggtgaaggcctacggggccgggctgctgtcctcctacggggagctcctg
cactccctgtcggaggagcccgagatccggcccttcgacccggacgccgcggccctgcag
ccgtaccaggatcagacgtaccagtccgtgtacttcgtgtccgagagtttcagcgacgcc
agggacaagctcaggagctacgcctcccgcatccagcgtcccttctccgtgaagtttgac
ccgtacacgctggccgtcgacgtgctggacagcccccaagccatccggcgctccctggag
ggcgtgcaggacgagctgcaggccctcagccacgcgctgaacgccctcggctga
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