KEGG   Plasmodium falciparum 3D7: PF3D7_0417200
Entry
PF3D7_0417200     CDS       T00095                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
pfa  Plasmodium falciparum 3D7
Pathway
pfa00240  Pyrimidine metabolism
pfa00670  One carbon pool by folate
pfa00790  Folate biosynthesis
pfa01100  Metabolic pathways
pfa01232  Nucleotide metabolism
pfa01240  Biosynthesis of cofactors
Module
pfa_M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
pfa_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:pfa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    PF3D7_0417200
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    PF3D7_0417200
   00670 One carbon pool by folate
    PF3D7_0417200
Enzymes [BR:pfa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     PF3D7_0417200
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     PF3D7_0417200
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 9221804
NCBI-ProteinID: XP_001351479
PlasmoDB: PF3D7_0417200
UniProt: Q8I1R6
Structure
LinkDB
Position
4:748088..749914
AA seq 608 aa
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCA
VTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTSWESIPKKFKPLS
NRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIK
KIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCI
KGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE
EKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKF
DLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH
REVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVK
DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP
AQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE
KISMDMAA
NT seq 1827 nt   +upstreamnt  +downstreamnt
atgatggaacaagtctgcgacgttttcgatatttatgccatatgtgcatgttgtaaggtt
gaaagcaaaaatgaggggaaaaaaaatgaggtttttaataactacacatttagaggtcta
ggaaataaaggagtattaccatggaaatgtaattccctagatatgaaatatttttgtgca
gttacaacatatgtgaatgaatcaaaatatgaaaaattgaaatataagagatgtaaatat
ttaaacaaagaaactgtggataatgtaaatgatatgcctaattctaaaaaattacaaaat
gttgtagttatgggaagaacaagctgggaaagcattccaaaaaaatttaaacctttaagc
aataggataaatgttatattgtctagaaccttaaaaaaagaagattttgatgaagatgtt
tatatcattaacaaagttgaagatctaatagttttacttgggaaattaaattactataaa
tgttttattataggaggttccgttgtttatcaagaatttttagaaaagaaattaataaaa
aaaatatattttactagaataaatagtacatatgaatgtgatgtattttttccagaaata
aatgaaaatgagtatcaaattatttctgttagcgatgtatatactagtaacaatacaaca
ttggattttatcatttataagaaaacgaataataaaatgttaaatgaacaaaattgtata
aaaggagaagaaaaaaataatgatatgcctttaaagaatgatgacaaagatacatgtcat
atgaaaaaattaacagaattttacaaaaatgtagacaaatataaaattaattatgaaaat
gatgatgatgatgaagaagaagatgattttgtttattttaattttaataaagaaaaagaa
gagaaaaataaaaattctatacatccaaatgattttcaaatatataatagcttgaaatat
aaatatcatcctgaataccaatatttaaatattatttatgatattatgatgaatggaaat
aaacaaagtgatcgaacgggagtaggtgttttaagtaaattcggatatattatgaaattt
gatttaagtcaatatttcccattattaactacgaagaaattatttttaagaggaattatt
gaagaattgctttggtttattagaggagaaacaaatggtaatacgttgttaaataagaat
gtaaggatatgggaagctaatggtactagggaatttttagataatagaaaattatttcat
agagaagttaacgatttaggacctatttatggttttcaatggagacatttcggtgctgaa
tatacaaatatgtatgataattatgaaaataaaggagtggatcaattaaaaaatataata
aatttaattaaaaatgatcctacaagtagaagaattcttttgtgtgcatggaatgtaaaa
gatcttgaccaaatggcattacctccttgtcatattttatgtcagttttatgttttcgat
gggaaattatcatgtattatgtatcaaagatcatgtgatttagggctaggagtacctttt
aatattgcttcttattctatttttactcatatgattgcacaagtctgtaatttgcaacct
gcgcagttcatacacgttttaggaaatgcacatgtttataataatcacattgatagttta
aaaattcaacttaacagaataccctatccattcccaacacttaaattaaatccagatatt
aaaaatattgaagattttacaatttcggattttacaatacaaaattatgttcatcatgaa
aaaatttcaatggatatggctgcttaa

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