KEGG   Plasmodium gaboni: PGSY75_0417200
Entry
PGSY75_0417200    CDS       T08136                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
pgab  Plasmodium gaboni
Pathway
pgab00240  Pyrimidine metabolism
pgab00670  One carbon pool by folate
pgab00790  Folate biosynthesis
pgab01100  Metabolic pathways
pgab01232  Nucleotide metabolism
pgab01240  Biosynthesis of cofactors
Module
pgab_M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
pgab_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:pgab00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    PGSY75_0417200
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    PGSY75_0417200
   00670 One carbon pool by folate
    PGSY75_0417200
Enzymes [BR:pgab01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     PGSY75_0417200
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     PGSY75_0417200
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 29774839
NCBI-ProteinID: XP_018643384
UniProt: A0A151LUJ9
LinkDB
Position
4:510421..512247
AA seq 608 aa
MMEQVCDVFDIYAICACCKVENKNEVKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCA
VTTYVNESKYEKLKYKRCKYLNKETLNNVMDMPNSKKLQNVVVMGRTSWESIPKKFKPLS
NRINVILSRTLKKEDIDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYKEFLEKKLIK
KIYFTRINSSYECDVFFPEINENEYQIISVSDVYTSNNTTLDFVIYKKKNNQVLNEKDCI
KGEEENNDMSLKNDDKVTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE
EKNKNCVHPNDFKIYNSLKHKCHPEYQYLNIIYDIIMNGNKQSDRTGVGVLSKFGYIMKF
DLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH
REVNDLGPIYGFQWRHFGAEYTNMHDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVK
DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP
AEFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE
KISMDMAA
NT seq 1827 nt   +upstreamnt  +downstreamnt
atgatggaacaagtctgcgacgttttcgatatttatgccatatgtgcatgttgtaaggtt
gaaaataaaaatgaggtgaaaaaaaacgaggtttttaataactacacatttagaggttta
ggaaataaaggagtattgccatggaaatgtaattcactagatatgaaatatttttgtgcc
gttactacatatgtgaatgaatcaaaatatgaaaaattgaaatataagagatgtaaatat
ttaaacaaagaaacgctgaataatgtaatggatatgcctaattcgaaaaaattacaaaat
gttgtagttatgggaagaacaagttgggaaagtattccaaaaaaatttaaacctttaagc
aaccgaataaatgttatattgtcgagaacattaaaaaaagaagatattgatgaagatgtt
tatatcattaacaaagttgaagatctaatagttttacttggaaaattaaattattataaa
tgttttattattggaggttccgttgtttataaagaatttttagaaaagaaattaatcaaa
aagatatactttactagaataaatagttcatatgaatgtgatgtattttttccagaaata
aatgaaaatgagtatcaaattatttctgttagtgatgtatatactagtaacaatacaaca
ttggattttgttatttataaaaaaaagaataatcaagtgttaaatgaaaaagactgtata
aaaggagaagaagaaaataatgatatgtctttaaaaaatgatgacaaagttacatgtcat
atgaaaaaattaacagaattttataaaaatgtggacaaatataaaattaattatgaaaat
gatgatgatgatgaagaagaagatgattttgtttattttaattttaataaagaaaaagaa
gagaaaaataaaaattgtgtacatccaaatgattttaaaatatataatagtttgaaacat
aaatgtcatcctgaatatcaatatttaaatattatatatgatattataatgaatggaaat
aaacaaagtgatcgaacaggagtaggtgttttaagtaaattcggatatattatgaaattt
gatttaagtcaatatttcccattattaactacaaagaaattattcttaagaggaattatt
gaagaattgctttggtttattagaggagaaacaaatggtaatacgctgttaaataagaat
gtaaggatatgggaagctaatggtactagggaatttttagataatagaaaattatttcat
agagaagttaacgatttaggacctatttatggttttcaatggagacatttcggagctgaa
tatacaaatatgcatgataattatgaaaataaaggtgttgatcaattaaaaaatataata
aatttaattaaaaatgatcctacaagtagaagaattcttttgtgtgcatggaatgtaaaa
gatcttgaccaaatggcattacctccttgtcatattttatgtcaattttatgttttcgat
ggaaaattatcatgtattatgtatcaaaggtcatgtgatttaggactaggagtacctttt
aatattgcttcttattctatttttactcatatgattgcacaagtctgtaatttgcaacct
gccgaatttatacacgttttaggaaatgcgcatgtttataataatcacatcgatagttta
aaaattcaacttaatagaataccatatccattcccaacacttaaattaaatccagatatt
aaaaatattgaagattttacaatttcggattttacaatacaaaattatgttcatcatgaa
aaaatttcaatggatatggctgcctaa

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