KEGG   Phyllostomus hastatus (greater spear-nosed bat): 123831227
Entry
123831227         CDS       T07912                                 
Symbol
AKR1C8
Name
(RefSeq) putative aldo-keto reductase family 1 member C8 isoform X1
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
phas  Phyllostomus hastatus (greater spear-nosed bat)
Pathway
phas00140  Steroid hormone biosynthesis
phas00590  Arachidonic acid metabolism
phas00790  Folate biosynthesis
phas01100  Metabolic pathways
phas04913  Ovarian steroidogenesis
phas05208  Chemical carcinogenesis - reactive oxygen species
Module
phas_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:phas00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    123831227 (AKR1C8)
   00590 Arachidonic acid metabolism
    123831227 (AKR1C8)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    123831227 (AKR1C8)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    123831227 (AKR1C8)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    123831227 (AKR1C8)
Enzymes [BR:phas01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     123831227 (AKR1C8)
    1.1.1.188  prostaglandin-F synthase
     123831227 (AKR1C8)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     123831227 (AKR1C8)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     123831227 (AKR1C8)
SSDB
Motif
Pfam: Aldo_ket_red GT-D-like
Other DBs
NCBI-GeneID: 123831227
NCBI-ProteinID: XP_045713985
LinkDB
Position
Unknown
AA seq 338 aa
MDLKHSRSVKLNDGHFMPVLAFGTLASDDVPKSKAAEATKMAIDVGFRHIDAAYVYQNEK
EVGQAIRDKIADGTVKREDIFYTTKLWATFLRPELVRPALERSLKNLQLDYVDLFIIHIP
TAMKPGEDLIPKDVSGKVILDTVDLRDTWEALEKCKDAGLTKSIGVSNFNHKLLEMILNK
PGLKYKPVCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRDPTWVEKDSPILLEDP
IMNAIAKKHSRNPGQVALRYQVQRGVVVLAKSFNEKRIKENFQIFDFELTPEDIKAIDGL
NRNFRFFQLLMRKHGYAHNEHVIMTAPWTLFIFVLTQL
NT seq 1017 nt   +upstreamnt  +downstreamnt
atggacctcaaacacagtcgttctgtgaaactgaatgatgggcatttcatgccagtgctt
gcatttggcactcttgcttctgatgatgttcctaagagcaaggctgctgaggccaccaaa
atggcaattgatgtaggtttccgtcacatcgacgcggcatacgtctatcaaaacgagaag
gaggttggccaggccattcgagacaaaatcgcggatggcactgtgaagagagaggacata
ttctacaccaccaagctttgggctactttccttcgaccagaactggttcgaccagccctg
gaaagatcactgaagaatcttcaactggactatgtagatctcttcatcattcatattcca
acagcaatgaagcctggagaggaccttataccaaaggatgtcagtgggaaagttatttta
gatacagtggacttacgtgacacgtgggaggccctggagaagtgtaaggatgcaggttta
accaagtccattggggtgtccaatttcaatcacaaactgctggagatgatcctgaacaag
ccagggctcaagtacaagcctgtctgcaaccaggtggaatgtcacccgtacctcaaccag
agcaaactgctggagttctgcaagtccaaggacattgttcttgttgcttacagtgccctg
gggtcccaaagagaccctacctgggtggaaaaggatagccccattctcttggaggatcca
attatgaatgccattgccaagaaacacagcagaaatccagggcaagtggccctgcgctac
caagtgcagagaggggtggtggtcctggccaagagcttcaatgagaagagaatcaaagag
aacttccagatttttgactttgaactgactccagaagacattaaagcaattgatggcctc
aacagaaatttccgtttttttcaactactaatgagaaaacatggctatgctcataatgaa
catgtaataatgactgcaccctggaccctattcatttttgtcctaacacaattgtga

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