KEGG   Plasmodium knowlesi: PKNH_0509600
Entry
PKNH_0509600      CDS       T01094                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
pkn  Plasmodium knowlesi
Pathway
pkn00240  Pyrimidine metabolism
pkn00670  One carbon pool by folate
pkn00790  Folate biosynthesis
pkn01100  Metabolic pathways
pkn01232  Nucleotide metabolism
pkn01240  Biosynthesis of cofactors
Module
pkn_M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
pkn_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:pkn00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    PKNH_0509600
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    PKNH_0509600
   00670 One carbon pool by folate
    PKNH_0509600
Enzymes [BR:pkn01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     PKNH_0509600
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     PKNH_0509600
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 7319328
NCBI-ProteinID: XP_002258228
UniProt: A0A5K1U9J7 A0A384KN43
LinkDB
Position
5:404904..406784
AA seq 626 aa
MEDLSEVFDIYAICACCKVTPPNDGIKNEPFGPRTFRGLGNNGALPWKCNSVDMKYFSSV
TTYVDESKYEKLKWKRERYLQREASVGNVETHCGGDTVETEDNTTKLQNVVVMGRSSWES
IPKQYKPLPNRINVVLSKTLTHEQVKEKVFIIQSIDDLLLLLKKLKYYKCFIIGGAQVYK
ECLNRNLIKQIYFTRINNAYQCDVLFPQFDEGQFRMTSVSEVYNNKGTTLDFVIYSKVGG
EVDGGASNGSTMDMDSGSENCENVKCGAPNCNTSGCISPNCTSTREEKWRKCSPACQWKK
SNADVEEDDLVYFSFNNKVGEKNPEHLQDFKIYNSVKIKQHPEYQYLSIIYDIIMNGNKQ
GDRTGVGVMSKFGYMMKFNLNEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLKKNVR
IWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYEDKGVDQLKNVIHL
IKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNI
ASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHIDSLKVQLNRIPYPFPTLKLNPEVKN
IEDFTISDFTIENYVHHDKIAMEMAA
NT seq 1881 nt   +upstreamnt  +downstreamnt
atggaagacctttcagaggtattcgatatttacgctatctgcgcctgctgcaaggtcacc
cctcctaatgatgggataaagaatgagccgtttggcccgcgaacctttaggggtcttgga
aataatggggctcttccatggaaatgcaactccgttgacatgaagtatttcagctcggtg
acgacctacgtagatgagtccaagtacgagaagttaaagtggaagagggagaggtacctg
caaagagaggcctcagtggggaatgttgaaacccactgtggtggtgacactgtagagacg
gaggataacaccaccaagctgcaaaacgttgtggtaatgggaagaagcagttgggagagc
attcccaaacagtacaaaccactcccaaacagaatcaatgtcgttctttccaagactcta
acacatgaacaggtgaaggaaaaagtttttataattcagagtatagatgacctactactt
cttttaaaaaagctgaagtactacaaatgcttcattattggaggagcacaagtttataag
gaatgtctaaataggaacttaattaagcagatatacttcacaaggattaacaacgcttat
cagtgtgatgttctgttcccacagtttgatgaaggtcagtttagaatgacatcggtcagc
gaggtgtacaacaacaagggcaccactctggactttgtgatttacagcaaggtagggggg
gaagtagatgggggcgcttccaatggaagcacgatggatatggatagtggttcggaaaac
tgcgagaatgtaaaatgtggcgcaccaaactgcaacacctccggttgtatctcccccaat
tgcacgagcacgcgtgaagagaaatggaggaagtgctcccccgcgtgtcagtggaagaag
agcaacgccgatgtagaggaagatgacctcgtatactttagctttaacaataaagtagga
gagaaaaacccagagcatctgcaggattttaaaatatataatagcgtcaagattaagcag
cacccagagtaccaatacctaagcatcatatatgacatcatcatgaatggaaacaaacaa
ggagatagaacaggtgtgggagtgatgagtaaatttgggtatatgatgaaatttaattta
aatgaatatttccccctattaacaacaaagaaattatttctgaggggaataattgaagag
ttgctctggttcattcggggagaaacaaacggaaacacattgttaaagaagaacgtgagg
atatgggaggcaaatggaacgagggagttccttgacaataggaaattatttcacagagaa
gtgaatgacctgggacctatttatggtttccagtggagacactttggtgctgaatacaca
aacatgtatgacaattacgaagataaaggtgtagaccaattaaaaaatgttatccattta
ataaaaaatgaaccaacgagtaggagaattatcctatgtgcatggaatgttaaagatttg
gatcaaatggctttacctccttgtcatatcttatgtcaattttacgttttcgatgggaaa
ctgtcatgcattatgtatcaaaggtcttgtgacttgggtcttggggtccccttcaacata
gcatcttattccatattcacacacatgattgcacaggtgtgcaatttacagcctgcacag
ttcatacacattttgggaaatgcccacgtctacaacaaccacatagacagcctaaaagtg
cagctaaacaggattccctaccccttcccaacgcttaagctgaacccggaagtgaagaac
attgaagattttaccatttcagatttcacaatagagaactatgtgcatcacgataaaatc
gctatggagatggccgcctag

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