Panthera leo (lion): 122216536
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Entry
122216536 CDS
T10741
Symbol
HADHA
Name
(RefSeq) trifunctional enzyme subunit alpha, mitochondrial
KO
K07515
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:
4.2.1.17
1.1.1.211
]
Organism
plez Panthera leo (lion)
Pathway
plez00062
Fatty acid elongation
plez00071
Fatty acid degradation
plez00280
Valine, leucine and isoleucine degradation
plez00310
Lysine degradation
plez00380
Tryptophan metabolism
plez00410
beta-Alanine metabolism
plez00640
Propanoate metabolism
plez00650
Butanoate metabolism
plez01100
Metabolic pathways
plez01212
Fatty acid metabolism
Module
plez_M00032
Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
plez_M00085
Fatty acid elongation in mitochondria
plez_M00087
beta-Oxidation
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
122216536 (HADHA)
00650 Butanoate metabolism
122216536 (HADHA)
09103 Lipid metabolism
00062 Fatty acid elongation
122216536 (HADHA)
00071 Fatty acid degradation
122216536 (HADHA)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
122216536 (HADHA)
00310 Lysine degradation
122216536 (HADHA)
00380 Tryptophan metabolism
122216536 (HADHA)
09106 Metabolism of other amino acids
00410 beta-Alanine metabolism
122216536 (HADHA)
Enzymes [BR:
plez01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
122216536 (HADHA)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.17 enoyl-CoA hydratase
122216536 (HADHA)
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Gene cluster
GFIT
Motif
Pfam:
3HCDH_N
ECH_1
3HCDH
ECH_2
DUF7337
Motif
Other DBs
NCBI-GeneID:
122216536
NCBI-ProteinID:
XP_042789424
UniProt:
A0A8C9CYG0
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Position
A3:119040208..119089380
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AA seq
763 aa
AA seq
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MVASRAIGSLRRFTASRTLRCPGYTCRNFSASSALLTRTHINYGVKGDVAVVRINSPNSK
VNTLSRELQSEFIEVMNEIWANDQIRSAVLISSKPGCFIAGADINMLASCKSAEEVMQLS
QEGQRMLEKLEKSTKPIVAAISGSCLGGGLELAISCQYRIATKDRKTVLGSPEVLLGILP
GAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVEPLGPGLKPSEERTIEYL
EEVAVTFAKELSDKKISLKRDKGLVEKLTSYAMSIPFVRQQIYKKVEEKVRKQTKGLYPA
PLKIIDAVKTGIEQGNDAGYVSESQKFGELAMTKESKALMGLYHGQVLCKKNKFGTPQKD
VKHLAILGAGLMGAGIAQVSVDKGIKTILKDATLAGLDRGQQQVFKGLNDKVKKKALTSF
ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLNVKHRVLKEVEAVVPDHCVFASNTSALP
IRQIASVSKRPEKVVGMHYFSPVDKMQLLEIITTEKTSKDTTASVVAVGLKQGKVIVVVK
DGPGFYTTRCLAPMMSEVLRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA
EDLGKAFGERFEGGSVELLKQMVSRGFLGRKSGKGFYIYQEGVKNKSLNSDMDGILASLK
VPPKSDVCSDEDLQYRLVTRFVNEAIMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRY
VDLYGAQKIVDRLRKYEAAYGKPFTPCQLLIDHANSPNKKFYQ
NT seq
2292 nt
NT seq
+upstream
nt +downstream
nt
atggtggcctcccgggcgataggcagtctccgtcgcttcactgcctccaggacgctccgc
tgcccaggttatacctgccgcaacttttcagcatcctctgctttgctaaccagaacccat
attaactatggagtcaaaggggatgtggctgttgttcgaattaactcacccaattcaaag
gtaaatacactgagcagagaactgcaatcagagttcatagaagtaatgaatgaaatctgg
gctaatgatcaaatcagaagtgccgtccttatctcatcaaagccaggctgctttattgca
ggtgctgacatcaacatgttagcctcttgtaagagcgcggaagaggtaatgcagctatcg
caggagggccagagaatgcttgagaaacttgagaagtccacaaagcctattgtggctgcc
atcagtggatcctgcttaggaggaggacttgagcttgccatttcctgccaatacagaata
gccacaaaagataggaaaacagtattaggtagccctgaagtcttgctggggatcttacca
ggagcaggaggcacacaaaggctgcccaaaatggtgggtgtgcctgctgcttttgacatg
atgttgactggtagaaacattcgtgcagacagagcaaagaaaatgggactagttgaccaa
ttggtggaacccctgggaccaggactaaaaccttcagaggaacggacaattgaatatcta
gaagaagttgcagttacttttgccaaagaactatctgataagaaaatctctctaaagaga
gacaaaggattagtagaaaaattgacatcatatgccatgagcattccgtttgtcaggcaa
cagatttataaaaaggtggaagaaaaagtacgaaaacaaaccaaaggcctttatcctgca
cctctgaaaataatcgatgcagtaaagactggaattgagcaagggaatgatgctggctat
gtctctgaatctcagaaatttggagagcttgcaatgaccaaagaatcaaaggccttgatg
ggactttatcatggtcaggtcctgtgtaagaagaataaatttggaactccgcagaaggac
gtgaagcacctagccattcttggtgcagggctgatgggggccggcatcgcccaggtgtct
gtggataagggcataaagaccatccttaaagatgctacactagccgggctggaccgagga
cagcaacaagtgttcaaaggattgaatgataaagtgaagaagaaagctctaacgtcattt
gaaagggactccattttcagcaacttgactggacagctcgattaccagggttttgaaaag
gccgacatggtgattgaagctgtttttgaggatcttaatgttaaacacagagtgttaaag
gaagtagaagcggtggttccggatcactgtgtctttgccagtaacacgtctgctctcccc
atccgtcaaattgcctctgtcagcaaaagacctgagaaggtggttggcatgcactacttc
tctccggtggacaagatgcaactgctggagatcatcacaaccgagaaaacttctaaggac
acaactgcttccgtcgtggcagtcgggctcaagcaggggaaggtcatcgttgtggttaag
gacggacctggcttctataccacccggtgtctcgcacccatgatgtctgaagtcctccga
atcctccaggaaggagttgaccctaagaagctggattcccttaccacaagctttggcttt
cccgtgggtgctgccaccctggtcgatgaagttggcgtggacgtggcaaaacacgtggca
gaagatctaggcaaagcctttggggagcggtttgaaggcggaagcgtagaactgctgaag
cagatggtgtccaggggcttcctgggtcgcaagtctgggaagggcttttacatctaccag
gagggcgtgaagaataagagtttgaattctgacatggatggtattttggcaagtctgaag
gtgcctcctaagtctgacgtctgctctgacgaagacctccagtaccgcctggtgacaaga
tttgtgaatgaggccatcatgtgcctgcaggaagggatcctggccacgcccgcagaggga
gacatcggagccgtcttcgggcttggctttcccccgtgccttggagggcccttccgctat
gtggatctgtatggcgcccagaagatagtggacaggctcaggaagtacgaggctgcctac
ggaaaaccgttcaccccgtgccagctgctcattgaccacgctaacagccccaacaagaag
ttctaccagtga
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