Panthera leo (lion): 122216636
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Entry
122216636 CDS
T10741
Symbol
ADAM17
Name
(RefSeq) disintegrin and metalloproteinase domain-containing protein 17 isoform X1
KO
K06059
disintegrin and metalloproteinase domain-containing protein 17 [EC:
3.4.24.86
]
Organism
plez Panthera leo (lion)
Pathway
plez04148
Efferocytosis
plez04330
Notch signaling pathway
plez04668
TNF signaling pathway
plez05010
Alzheimer disease
plez05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
plez00001
]
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
122216636 (ADAM17)
04668 TNF signaling pathway
122216636 (ADAM17)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
122216636 (ADAM17)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
122216636 (ADAM17)
09164 Neurodegenerative disease
05010 Alzheimer disease
122216636 (ADAM17)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
plez01002
]
122216636 (ADAM17)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
plez04090
]
122216636 (ADAM17)
Enzymes [BR:
plez01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.86 ADAM 17 endopeptidase
122216636 (ADAM17)
Peptidases and inhibitors [BR:
plez01002
]
Metallo peptidases
Family M12: astacin/adamalysin family
122216636 (ADAM17)
CD molecules [BR:
plez04090
]
Proteins
122216636 (ADAM17)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Reprolysin_2
Reprolysin_5
ADAM17_MPD
Disintegrin
Reprolysin_3
Reprolysin
Reprolysin_4
Pep_M12B_propep
Motif
Other DBs
NCBI-GeneID:
122216636
NCBI-ProteinID:
XP_042789643
UniProt:
A0A8C8WIM8
LinkDB
All DBs
Position
A3:132958267..133011297
Genome browser
AA seq
823 aa
AA seq
DB search
MRQCLLFLTSVVPFVLAPRPPDGPGFGSPQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QASTHLETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKDESEYAVKWQDFFTGHVV
GEPDSRVLAHIGDDDITVRINTDGAEYNIEPLWRLINDTKDKRMLVYKSEDIKNISRLQS
PKVCGYIKADNEELLPKGLVDREPPDELVHRVKRRADPNPMKNTCKLLVVADHRFYKYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQDVKPGERHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCSSECMLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAADDTVCLDLGKCKDGKCVPFCEREQRLESCACNETDNSC
KVCCRDPSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIVKPFPAPQAPGRPQPLQAAPAPPPPVPAAPKLDHQRMDTIQEDPSTDSHVDEDP
FPSSSTAAKSFEDLTGRPVTRSEKASSFKLQRQNRVGSKETEC
NT seq
2472 nt
NT seq
+upstream
nt +downstream
nt
atgaggcagtgtctcctcttcctgaccagcgtggttcctttcgtgctggcgccgcgacct
ccggacgggccgggcttcggctccccgcagcgactcgaaaagcttgattctttactctca
gactacgatatcctctctttatccaatatccagcagcactcagtaagaaaacgggatcta
caagcctcaacacatttagaaacactactaactttttcagccttgaaaaggcattttaaa
ttatacctgacgtcaagtactgaacgcttttcccagaatttcaaagtcgtggtggtagat
ggtaaagacgaaagcgagtatgccgtcaagtggcaggacttcttcactggacacgtggtc
ggtgagcctgactctagagttctagcccacataggagatgatgatattacagtaagaatc
aacacagatggggcagaatataatatagagccactttggagactaattaatgatactaaa
gacaaaagaatgttagtttataaatctgaagatatcaagaatatttcacgtctgcagtct
ccaaaagtgtgtggttatataaaggcggataatgaagagttgcttccaaaagggctagta
gacagagagccacccgacgagcttgttcatcgggtgaagagacgagctgaccctaatccc
atgaagaacacgtgtaaattgttggtggtagcagatcatcgcttttacaaatacatgggc
agaggggaagagagcacaactacaaattacttgatagagcttattgacagagttgatgac
atctatcggaacacttcatgggacaacgcgggttttaaaggttacggaatacagatcgag
cagattcgcattctcaagtctccacaagatgtgaaacctggtgaaaggcactataacatg
gcaaaaagttacccaaatgaagaaaaggatgcttgggatgtgaagatgttgctagagcaa
tttagctttgatatagctgaggaagcatctaaagtctgcctcgcacatcttttcacctat
caagattttgatatgggaactcttggattagcttacgtcggttctcccagagcaaacagc
cacggaggtgtttgtccaaaggcttactatagtccaattggaaagaagaatatctatttg
aatagtggtttgaccagcacaaaaaattatggtaaaaccatccttacaaaggaagctgac
ctggttacaactcatgaattgggacacaattttggagcagaacatgatccggatggccta
gcggaatgtgccccaaatgaggaccagggaggaaaatatgttatgtatcccatagcggtg
agtggagatcacgagaacaataagatgttttcaaactgcagtaagcagtccatctataag
accattgaaagtaaggcccaggagtgtttccaagaacgaagcaacaaagtgtgtgggaac
tccagggtggacgaaggagaggagtgcgatcctggcatcatgtacctgaacaacgacacc
tgctgcagcagcgaatgcatgctcaaggagggtgtgcagtgcagtgataggaacagtcct
tgctgtaaaaactgtcagttcgagactgcccagaagaagtgccaggaggctattaatgct
acttgcaaaggcgtgtcttactgcacaggtaacagcagcgagtgcccccctcccggaaac
gccgcggatgacacggtgtgcttggatcttggcaagtgtaaagacgggaagtgcgttccc
ttctgtgagagggagcagcggctggagtcctgtgcgtgtaacgagactgacaactcgtgc
aaggtgtgctgccgggacccctcgggccggtgcgtgccctatgtggacgccgaacaaaag
aacttattcttgaggaaaggaaagccctgtacggtgggattttgtgacatgaatggcaaa
tgtgagaaacgagtccaggacgtcatcgagcgattctgggacttcattgaccagttgagc
atcaacacttttgggaagtttttagcggacaacatcgtgggttccgtcctggttttctcc
ttgatattttggatccctttcagcattcttgtccattgtgtggataagaaactggataag
cagtacgagtcgctgtctctgttccaccccagcaacgtggaaatgctaagcagcatggac
tcggcctcggttcgcatcgtcaagcccttccccgcgccccaggcccccggccgcccgcag
cccctccaggccgcccccgcgccgccgccgccggtgcctgcggctcccaagctggaccac
cagcgcatggacacgatccaggaggaccccagcacggactcgcacgtggacgaggacccc
ttccccagcagcagcacggccgccaagtcgttcgaggacctcacgggccggcccgtcacg
aggagcgagaaggcctcgtccttcaagctgcagcgccagaaccgcgtgggcagcaaggag
acagagtgctag
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