KEGG   ORTHOLOGY: K06059
Entry
K06059                      KO                                     
Symbol
ADAM17, TACE, CD156b
Name
disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Pathway
map04330  Notch signaling pathway
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05171  Coronavirus disease - COVID-19
Disease
H02467  Neonatal inflammatory skin and bowel disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
CD molecules [BR:ko04090]
 Proteins
  K06059  CD156b, ADAM17; a disintegrin and metalloproteinase domain 17
Genes
HSA: 6868(ADAM17)
PTR: 459018(ADAM17)
PPS: 100988650(ADAM17)
GGO: 101152705(ADAM17)
PON: 100439426(ADAM17)
NLE: 100605134(ADAM17)
MCC: 694429(ADAM17)
MCF: 102116784(ADAM17)
CSAB: 103220846(ADAM17)
CATY: 105587543(ADAM17)
PANU: 100126726(ADAM17)
TGE: 112604761(ADAM17)
RRO: 104675213(ADAM17)
RBB: 108516165(ADAM17)
TFN: 117062750(ADAM17)
PTEH: 111531765(ADAM17)
CJC: 100406520(ADAM17)
SBQ: 101049053(ADAM17)
CSYR: 103273750(ADAM17)
MMUR: 105882940(ADAM17)
OGA: 100947870(ADAM17)
MMU: 11491(Adam17)
MCAL: 110306467(Adam17)
MPAH: 110324376(Adam17)
RNO: 57027(Adam17)
MCOC: 116080989(Adam17)
MUN: 110564190(Adam17)
CGE: 100684971(Adam17)
PLEU: 114698857(Adam17)
NGI: 103747629(Adam17)
HGL: 101720924(Adam17)
CPOC: 100732916(Adam17)
CCAN: 109695934(Adam17)
DORD: 105983695(Adam17)
DSP: 122108773(Adam17)
NCAR: 124962735
OCU: 100101613(ADAM17)
OPI: 101532279(ADAM17)
TUP: 102496316(ADAM17)
CFA: 475662(ADAM17)
VVP: 112927728(ADAM17)
VLG: 121491142(ADAM17)
AML: 100482770(ADAM17)
UMR: 103675912(ADAM17)
UAH: 113269710(ADAM17)
UAR: 123778537(ADAM17)
ELK: 111154187
LLV: 125108380
MPUF: 101678822(ADAM17)
ORO: 101378266(ADAM17)
EJU: 114205773(ADAM17)
ZCA: 113937386(ADAM17)
FCA: 101089004(ADAM17)
PYU: 121044072(ADAM17)
PBG: 122497481(ADAM17)
PTG: 102948618(ADAM17)
PPAD: 109268814(ADAM17)
AJU: 106982950(ADAM17)
HHV: 120231128(ADAM17)
BTA: 517541(ADAM17)
BOM: 102279111(ADAM17)
BIU: 109566404(ADAM17)
BBUB: 102393245(ADAM17)
CHX: 102188327(ADAM17)
OAS: 101116815(ADAM17)
ODA: 120851888(ADAM17)
CCAD: 122442085(ADAM17)
SSC: 397343(ADAM17)
CFR: 102508816(ADAM17)
CBAI: 105076036(ADAM17)
CDK: 105091236(ADAM17)
VPC: 102542735(ADAM17)
BACU: 103004501(ADAM17)
LVE: 103086820(ADAM17)
OOR: 101272366(ADAM17)
DLE: 111164496(ADAM17)
PCAD: 102978565(ADAM17)
PSIU: 116763969(ADAM17)
ECB: 100072496(ADAM17)
EPZ: 103543937 103560849(ADAM17)
EAI: 106847480(ADAM17)
MYB: 102256292(ADAM17)
MYD: 102767398(ADAM17)
MMYO: 118669297(ADAM17)
MLF: 102425078(ADAM17)
MNA: 107526643(ADAM17)
PKL: 118715935(ADAM17)
HAI: 109386655(ADAM17)
DRO: 112297707(ADAM17)
SHON: 118988749(ADAM17)
AJM: 119053993(ADAM17)
PDIC: 114499294(ADAM17)
PHAS: 123822573(ADAM17)
MMF: 118630463(ADAM17)
RFQ: 117032918(ADAM17)
PALE: 102894565(ADAM17)
PGIG: 120622059(ADAM17)
PVP: 105295437(ADAM17)
RAY: 107498263(ADAM17)
TOD: 119259567(ADAM17)
SARA: 101541255(ADAM17)
LAV: 100663807(ADAM17)
TMU: 101350544
DNM: 101418734(ADAM17)
MDO: 100032069(ADAM17)
GAS: 123237029(ADAM17)
SHR: 100926795(ADAM17)
PCW: 110212614(ADAM17)
OAA: 100086345(ADAM17)
GGA: 421931(ADAM17)
PCOC: 116240757(ADAM17)
MGP: 100549409(ADAM17)
CJO: 107312200(ADAM17)
NMEL: 110395713(ADAM17)
APLA: 101794295(ADAM17)
ACYG: 106030708(ADAM17)
AFUL: 116487500(ADAM17)
TGU: 100225922(ADAM17)
LSR: 110467958(ADAM17)
SCAN: 103820444(ADAM17)
PMOA: 120505304(ADAM17)
OTC: 121344379(ADAM17)
PRUF: 121359136(ADAM17)
GFR: 102034165(ADAM17)
FAB: 101814343(ADAM17)
PHI: 102106429(ADAM17)
PMAJ: 107201529(ADAM17)
CCAE: 111925944(ADAM17)
CCW: 104685448(ADAM17)
ETL: 114058979(ADAM17)
ZAB: 102062655(ADAM17)
FPG: 101924106(ADAM17)
FCH: 102055911(ADAM17)
CLV: 102098173(ADAM17)
EGZ: 104127159(ADAM17)
NNI: 104013024(ADAM17)
ACUN: 113478354(ADAM17)
TALA: 104357741(ADAM17)
PADL: 103924054(ADAM17)
ACHC: 115350914(ADAM17)
AAM: 106494759(ADAM17)
AROW: 112976492(ADAM17)
NPD: 112945452(ADAM17)
DNE: 112981540(ADAM17)
ASN: 102373202(ADAM17)
AMJ: 102560812(ADAM17)
CPOO: 109312094(ADAM17)
GGN: 109300145(ADAM17)
PSS: 102454376(ADAM17)
CMY: 102933390(ADAM17)
CPIC: 101938160(ADAM17)
TST: 117875291(ADAM17)
CABI: 116823114(ADAM17)
MRV: 120401271(ADAM17)
ACS: 100563907(adam17)
PVT: 110080585(ADAM17)
SUND: 121927898(ADAM17)
PBI: 103060091(ADAM17)
PMUR: 107295813(ADAM17)
PGUT: 117674213(ADAM17)
VKO: 123017146(ADAM17)
PMUA: 114593781(ADAM17)
ZVI: 118082396(ADAM17)
GJA: 107112820(ADAM17)
STOW: 125433705(ADAM17)
XLA: 108718238(adam17.S) 733430(adam17.L)
XTR: 100492947(adam17)
NPR: 108789869(ADAM17)
RTEM: 120936358(ADAM17)
BBUF: 120997413(ADAM17)
DRE: 324142(adam17a) 560657(adam17b)
PPRM: 120476738(adam17a) 120493978(adam17b)
MAMB: 125269329(adam17a) 125277828(adam17b)
IPU: 108257789(adam17b) 108270063(adam17a)
PHYP: 113531802 113538559(adam17)
SMEO: 124377472(adam17b) 124390219(adam17a)
TFD: 113655629(adam17b) 113659686(adam17a)
EEE: 113570511 113579136(adam17)
TRU: 101063716(adam17) 101075639
NCC: 104953609(adam17)
CGOB: 115027586(adam17)
ELY: 117266979(adam17a) 117270804(adam17b)
PLEP: 121953389(adam17a) 121955712
SLUC: 116035705(adam17a) 116061359
ECRA: 117936317(adam17a)
PFLV: 114546481(adam17)
GAT: 120815238 120833295(adam17a)
PPUG: 119195236 119227477(adam17a)
MSAM: 119909392(adam17b) 119910413(adam17a)
CUD: 121521362(adam17b) 121526184(adam17a)
OAU: 116312411(adam17b) 116334721(adam17a)
OML: 112149788(adam17a) 112157702(adam17b)
XMA: 102222153 102227287(adam17)
XCO: 114134256 114158418(adam17)
XHE: 116709412 116734229(adam17)
PRET: 103457157(adam17) 103458871
PFOR: 103144243 103146799(adam17)
PLAI: 106954181 106958488(adam17)
PMEI: 106925343(adam17) 106926881
GAF: 122825649(adam17b) 122846679(adam17a)
CVG: 107087577 107089571(adam17)
CTUL: 119784254(adam17a) 119789424(adam17b)
GMU: 124855404 124882393(adam17b)
NFU: 107377926 107392286(adam17)
KMR: 108236986(adam17a) 108249691(adam17b)
ALIM: 106521553 106530770(adam17)
NWH: 119418690(adam17b) 119427330(adam17a)
CSEM: 103377555(adam17) 103381366
SSEN: 122782844(adam17a) 122784344(adam17b)
HHIP: 117755872(adam17a) 117758776(adam17b)
LCF: 108888136(adam17) 108891569
SLAL: 111644771(adam17) 111672592
XGL: 120788898(adam17b) 120795416(adam17a)
HCQ: 109526133(adam17) 109531720
BPEC: 110155414(adam17) 110164254
OTW: 112217454(adam17b) 112247281 112256502(adam17a)
OMY: 110498110 110505320(adam17a) 110522060(adam17b)
OGO: 123994869(adam17b) 124001138 124046303(adam17a)
SNH: 120019620(adam17b) 120023088(adam17a) 120060189
SFM: 108921884(adam17)
PKI: 111842019
AANG: 118223873 118230860(adam17b)
LOC: 102682214(adam17)
PSPA: 121315402 121317536(adam17b)
ARUT: 117402183(adam17a) 117411384(adam17b)
LCM: 102367618(ADAM17)
CMK: 103187122(adam17b)
RTP: 109924946(adam17)
BFO: 118404014
BBEL: 109473119
CIN: 100175230
SCLV: 120332865
SPU: 585715
APLC: 110985040
SKO: 102803736
DME: Dmel_CG7908(Tace)
DER: 6554190
DSE: 6612793
DSI: Dsimw501_GD21492(Dsim_GD21492)
DAN: 6501584
DSR: 110186406
DPE: 6594801
DMN: 108155302
DWI: 6650344
DGR: 6567576
DAZ: 108609115
DNV: 108659297
DHE: 111596420
DVI: 6635224
CCAT: 101448581
BOD: 106618981
MDE: 101891592
SCAC: 106081862
LCQ: 111686124
ACOZ: 120949087
AARA: 120894455
AAG: 5563722
AALB: 109424331
CPII: 120421188
CNS: 116346870
AME: 551599
ACER: 108000097
ALAB: 122717424
BIM: 100745543
BBIF: 117212151
BVK: 117240411
BVAN: 117162798
BTER: 100645870
BPYO: 122566715
CCAL: 108623713
OBB: 114877479
MGEN: 117227229
NMEA: 116432844
CGIG: 122396464
SOC: 105197464
MPHA: 105839042
AEC: 105143101
ACEP: 105623272
PBAR: 105427116
VEM: 105561144
HST: 105184135
DQU: 106750237
CFO: 105258924
FEX: 115241593
LHU: 105669279
PGC: 109861730
OBO: 105282848
PCF: 106793988
PFUC: 122521241
VPS: 122637869
NVI: 100119121
CSOL: 105364600
TPRE: 106654176
MDL: 103578657
CGLO: 123270939
FAS: 105266951
DAM: 107041094
AGIF: 122855408
CCIN: 107265431
TCA: 663540
DPA: 109537991
SOY: 115875020
ATD: 109602707
AGB: 108914225
LDC: 111506628
NVL: 108563900
PPYR: 116161187
OTU: 111419993
BMOR: 101742406
BMAN: 114240363
MSEX: 115440097
BANY: 112051369
PMAC: 106713573
PPOT: 106104922
PXU: 106122629
PRAP: 111003508
HAW: 110384278
TNL: 113503404
SLIU: 111354966
OFU: 114352070
PXY: 105386060
API: 100158671
DNX: 107167450
AGS: 114130986
RMD: 113559354
BTAB: 109032996
DCI: 103515131
CLEC: 106673239
HHAL: 106685230
NLU: 111053184
FOC: 113217343
ZNE: 110836194
FCD: 110845600
HAME: 121869162
PCLA: 123764791
PTRU: 123504923
HAZT: 108674819
EAF: 111713207
DSV: 119460684
RSAN: 119396531
RMP: 119174711
CSCU: 111618821
PTEP: 107455115
SDM: 118180981
CEL: CELE_ZK154.7(adm-4)
CBR: CBG_16796(Cbr-adm-4)
BMY: BM_BM7430(Bma-adm-4)
TSP: Tsp_02601
OBI: 106881514
OSN: 115220007
LAK: 106153651
EGL: EGR_00581
NVE: 5511423
EPA: 110250562
ATEN: 116292316
ADF: 107358831
AMIL: 114948654
PDAM: 113681067
SPIS: 111328065
DGT: 114528597
XEN: 124447472
HMG: 100210793
 » show all
Reference
PMID:9034191
  Authors
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al.
  Title
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
  Journal
Nature 385:733-6 (1997)
DOI:10.1038/385733a0
  Sequence
[hsa:6868]
Reference
  Authors
Thathiah A, Blobel CP, Carson DD
  Title
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
  Journal
J Biol Chem 278:3386-94 (2003)
DOI:10.1074/jbc.M208326200
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