KEGG   ORTHOLOGY: K06059
Entry
K06059                      KO                                     
Symbol
ADAM17, TACE, CD156b
Name
disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Pathway
map04148  Efferocytosis
map04330  Notch signaling pathway
map04668  TNF signaling pathway
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05171  Coronavirus disease - COVID-19
Disease
H02467  Neonatal inflammatory skin and bowel disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
   04668 TNF signaling pathway
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
CD molecules [BR:ko04090]
 Proteins
  K06059  CD156b, ADAM17; a disintegrin and metalloproteinase domain 17
Genes
HSA: 6868(ADAM17)
PTR: 459018(ADAM17)
PPS: 100988650(ADAM17)
GGO: 101152705(ADAM17)
PON: 100439426(ADAM17)
NLE: 100605134(ADAM17)
HMH: 116480211(ADAM17)
MCC: 694429(ADAM17)
MCF: 102116784(ADAM17)
MTHB: 126933776
MNI: 105486511(ADAM17)
CSAB: 103220846(ADAM17)
CATY: 105587543(ADAM17)
PANU: 100126726(ADAM17)
TGE: 112604761(ADAM17)
MLEU: 105528533(ADAM17)
RRO: 104675213(ADAM17)
RBB: 108516165(ADAM17)
TFN: 117062750(ADAM17)
PTEH: 111531765(ADAM17)
CANG: 105525335(ADAM17)
CJC: 100406520(ADAM17)
SBQ: 101049053(ADAM17)
CIMI: 108301849(ADAM17)
CSYR: 103273750(ADAM17)
MMUR: 105882940(ADAM17)
LCAT: 123636584(ADAM17)
PCOQ: 105806730(ADAM17)
OGA: 100947870(ADAM17)
MMU: 11491(Adam17)
MCAL: 110306467(Adam17)
MPAH: 110324376(Adam17)
RNO: 57027(Adam17)
MCOC: 116080989(Adam17)
ANU: 117716809(Adam17)
MUN: 110564190(Adam17)
CGE: 100684971(Adam17)
MAUA: 101828493(Adam17)
PROB: 127215298 127237593(Adam17)
PLEU: 114698857(Adam17)
MORG: 121432399(Adam17) 121438902
MFOT: 126501305
AAMP: 119807826(Adam17)
NGI: 103747629(Adam17)
HGL: 101720924(Adam17)
CPOC: 100732916(Adam17)
CCAN: 109695934(Adam17)
DORD: 105983695(Adam17)
DSP: 122108773(Adam17)
PLOP: 125356745(Adam17)
NCAR: 124962735
MMMA: 107137509(Adam17)
OCU: 100101613
OPI: 101532279(ADAM17)
TUP: 102496316(ADAM17)
GVR: 103610686(ADAM17)
CFA: 475662(ADAM17)
CLUD: 112664856(ADAM17)
VVP: 112927728(ADAM17)
VLG: 121491142(ADAM17)
NPO: 129510838(ADAM17)
AML: 100482770(ADAM17)
UMR: 103675912(ADAM17)
UAH: 113269710(ADAM17)
UAR: 123778537(ADAM17)
ELK: 111154187
LLV: 125108380
MPUF: 101678822(ADAM17)
MNP: 132021122(ADAM17)
MLK: 131807398(ADAM17)
NVS: 122915325(ADAM17)
ORO: 101378266(ADAM17)
EJU: 114205773(ADAM17)
ZCA: 113937386(ADAM17)
NSU: 110587392(ADAM17)
LWW: 102738586(ADAM17)
FCA: 101089004(ADAM17)
PYU: 121044072(ADAM17)
PCOO: 112864061(ADAM17)
PBG: 122497481(ADAM17)
PVIV: 125158339(ADAM17)
LRUF: 124503705
PTG: 102948618(ADAM17)
PPAD: 109268814(ADAM17)
PUC: 125937696
AJU: 106982950
HHV: 120231128(ADAM17)
BTA: 517541(ADAM17)
BOM: 102279111(ADAM17)
BIU: 109566404(ADAM17)
BBUB: 102393245(ADAM17)
BBIS: 104997349(ADAM17)
CHX: 102188327(ADAM17)
OAS: 101116815(ADAM17)
BTAX: 128055238(ADAM17)
ODA: 120851888(ADAM17)
CCAD: 122442085(ADAM17)
MBEZ: 129539087(ADAM17)
SSC: 397343(ADAM17)
CFR: 102508816(ADAM17)
CBAI: 105076036(ADAM17)
CDK: 105091236(ADAM17)
VPC: 102542735(ADAM17)
BACU: 103004501(ADAM17)
BMUS: 118905722(ADAM17)
LVE: 103086820(ADAM17)
OOR: 101272366(ADAM17)
DLE: 111164496(ADAM17)
PCAD: 102978565(ADAM17)
PSIU: 116763969(ADAM17)
NASI: 112394765(ADAM17)
ECB: 100072496(ADAM17)
EPZ: 103543937 103560849(ADAM17)
EAI: 106847480(ADAM17)
MYB: 102256292(ADAM17)
MYD: 102767398(ADAM17)
MMYO: 118669297(ADAM17)
MLF: 102425078(ADAM17)
PKL: 118715935(ADAM17)
EFUS: 103305599(ADAM17)
MNA: 107526643(ADAM17)
DRO: 112297707(ADAM17)
SHON: 118988749(ADAM17)
AJM: 119053993(ADAM17)
PDIC: 114499294(ADAM17)
PHAS: 123822573(ADAM17)
MMF: 118630463(ADAM17)
PPAM: 129067690(ADAM17)
HAI: 109386655(ADAM17)
RFQ: 117032918(ADAM17)
PALE: 102894565(ADAM17)
PGIG: 120622059(ADAM17)
PVP: 105295437(ADAM17)
RAY: 107498263(ADAM17)
MJV: 108398652(ADAM17) 108406598
TOD: 119259567(ADAM17)
SARA: 101541255(ADAM17)
LAV: 100663807(ADAM17)
TMU: 101350544
ETF: 101641143(ADAM17)
DNM: 101418734(ADAM17)
MDO: 100032069(ADAM17)
GAS: 123237029(ADAM17)
SHR: 100926795(ADAM17)
AFZ: 127548615
PCW: 110212614(ADAM17)
OAA: 100086345(ADAM17)
GGA: 421931(ADAM17)
PCOC: 116240757(ADAM17)
MGP: 100549409(ADAM17)
CJO: 107312200(ADAM17)
TPAI: 128088191(ADAM17)
LMUT: 125689571(ADAM17)
NMEL: 110395713(ADAM17)
APLA: 101794295(ADAM17)
ACYG: 106030708(ADAM17)
CATA: 118246149(ADAM17)
AFUL: 116487500(ADAM17)
TGU: 100225922(ADAM17)
LSR: 110467958(ADAM17)
SCAN: 103820444(ADAM17)
PMOA: 120505304(ADAM17)
OTC: 121344379(ADAM17)
PRUF: 121359136(ADAM17)
GFR: 102034165(ADAM17)
FAB: 101814343(ADAM17)
OMA: 130251684(ADAM17)
PHI: 102106429(ADAM17)
PMAJ: 107201529(ADAM17)
CCAE: 111925944(ADAM17)
CCW: 104685448(ADAM17)
CBRC: 103622851(ADAM17)
ETL: 114058979(ADAM17)
ZAB: 102062655(ADAM17)
ZLE: 135445354(ADAM17)
ACHL: 103811209(ADAM17)
SVG: 106865122(ADAM17)
MMEA: 130576652(ADAM17)
HRT: 120749949(ADAM17)
FPG: 101924106(ADAM17)
FCH: 102055911(ADAM17)
CLV: 102098173(ADAM17)
EGZ: 104127159(ADAM17)
NNI: 104013024(ADAM17)
PCRI: 104031903(ADAM17)
PLET: 104622291(ADAM17)
PCAO: 104053058(ADAM17)
ACUN: 113478354(ADAM17)
TALA: 104357741(ADAM17)
PADL: 103924054(ADAM17)
AFOR: 103895885(ADAM17)
ACHC: 115350914(ADAM17)
HLE: 104831248(ADAM17)
AGEN: 126046408
GCL: 127014468
CCRI: 104162249(ADAM17)
CSTI: 104550091(ADAM17)
CMAC: 104484666(ADAM17)
MUI: 104539665(ADAM17)
BREG: 104638126(ADAM17)
FGA: 104075420(ADAM17)
GSTE: 104253426(ADAM17)
LDI: 104350533(ADAM17)
MNB: 103776199(ADAM17)
OHA: 104336253(ADAM17)
NNT: 104399631(ADAM17)
SHAB: 115609394(ADAM17)
DPUB: 104308101(ADAM17)
PGUU: 104463942(ADAM17)
ACAR: 104522582(ADAM17)
CPEA: 104390068(ADAM17)
CVF: 104293745(ADAM17)
RTD: 128906738(ADAM17)
CUCA: 104066457(ADAM17)
TEO: 104371691(ADAM17)
BRHI: 104492889(ADAM17)
AAM: 106494759(ADAM17)
AROW: 112976492(ADAM17)
NPD: 112945452(ADAM17)
TGT: 104576511(ADAM17)
DNE: 112981540(ADAM17)
SCAM: 104147606(ADAM17)
ASN: 102373202(ADAM17)
AMJ: 102560812(ADAM17)
CPOO: 109312094(ADAM17)
GGN: 109300145(ADAM17)
PSS: 102454376(ADAM17)
CMY: 102933390(ADAM17)
CCAY: 125634554(ADAM17)
DCC: 119853372(ADAM17)
CPIC: 101938160(ADAM17)
TST: 117875291(ADAM17)
CABI: 116823114(ADAM17)
MRV: 120401271(ADAM17)
ACS: 100563907(adam17)
ASAO: 132782703(ADAM17)
PVT: 110080585(ADAM17)
SUND: 121927898(ADAM17)
PBI: 103060091(ADAM17)
PMUR: 107295813(ADAM17)
CTIG: 120302866(ADAM17)
PGUT: 117674213(ADAM17)
APRI: 131195933(ADAM17)
PTEX: 113432968(ADAM17)
NSS: 113416457(ADAM17)
VKO: 123017146(ADAM17)
PMUA: 114593781(ADAM17)
PRAF: 128410153(ADAM17)
ZVI: 118082396(ADAM17)
HCG: 128340529(ADAM17)
GJA: 107112820(ADAM17)
STOW: 125433705(ADAM17)
EMC: 129333377(ADAM17)
XLA: 108718238(adam17.S) 733430(adam17.L)
XTR: 100492947(adam17)
NPR: 108789869(ADAM17)
RTEM: 120936358(ADAM17)
BBUF: 120997413(ADAM17)
MUO: 115467158(ADAM17)
GSH: 117356874(ADAM17)
DRE: 324142(adam17a) 560657(adam17b)
PTET: 122324794(adam17b) 122361857(adam17a)
LROH: 127179302(adam17a) 127182844(adam17b)
OMC: 131523616(adam17a) 131527724(adam17b)
PPRM: 120476738(adam17a) 120493978(adam17b)
RKG: 130075457(adam17b) 130080283(adam17a)
MAMB: 125269329(adam17a) 125277828(adam17b)
TROS: 130560624(adam17a) 130565599(adam17b)
TDW: 130434396(adam17b) 130437270(adam17a)
MANU: 129417404(adam17a) 129429321(adam17b)
IPU: 108257789(adam17b) 108270063(adam17a)
IFU: 128601062(adam17b) 128612996(adam17a)
PHYP: 113531802 113538559(adam17)
SMEO: 124377472(adam17b) 124390219(adam17a)
TFD: 113655629(adam17b) 113659686(adam17a)
TVC: 132843230(adam17b) 132852675(adam17a)
TRN: 134320106(adam17b) 134324943(adam17a)
CMAO: 118815633(adam17b) 118823462(adam17a)
EEE: 113570511 113579136(adam17)
CHAR: 105897061(adam17b) 105897267(adam17a)
TRU: 101063716(adam17) 101075639
TFS: 130516153(adam17b) 130539694(adam17a)
NCC: 104953609(adam17)
TBEN: 117473782(adam17a)
CGOB: 115027586(adam17)
PGEO: 117467499
GACU: 117549910
EMAC: 134877193(adam17b) 134881429(adam17a)
ELY: 117266979(adam17a) 117270804(adam17b)
EFO: 125896904(adam17b) 125900530(adam17a)
PLEP: 121953389(adam17a) 121955712
SLUC: 116035705(adam17a) 116061359
ECRA: 117936317(adam17a)
ESP: 116670032(adam17)
PFLV: 114546481(adam17)
GAT: 120815238 120833295(adam17a)
PPUG: 119195236 119227477(adam17a)
AFB: 129103252(adam17a) 129107002(adam17b)
CLUM: 117751347(adam17a)
PSWI: 130202053(adam17a)
MSAM: 119909392(adam17b) 119910413(adam17a)
SCHU: 122861718(adam17a) 122862643(adam17b)
CUD: 121521362(adam17b) 121526184(adam17a)
ALAT: 119004926(adam17a) 119012752(adam17b)
OAU: 116312411(adam17b) 116334721(adam17a)
OML: 112149788(adam17a) 112157702(adam17b)
CSAI: 133461983(adam17a) 133464880(adam17b)
XMA: 102222153 102227287(adam17)
XCO: 114134256 114158418(adam17)
XHE: 116709412 116734229(adam17)
PRET: 103457157(adam17) 103458871
PFOR: 103144243 103146799(adam17)
PLAI: 106954181 106958488(adam17)
PMEI: 106925343(adam17) 106926881
GAF: 122825649(adam17b) 122846679(adam17a)
PPRL: 129354515(adam17b) 129374730
CVG: 107087577 107089571(adam17)
CTUL: 119784254(adam17a) 119789424(adam17b)
GMU: 124855404 124882393(adam17b)
NFU: 107377926 107392286(adam17)
KMR: 108236986(adam17a) 108249691(adam17b)
ALIM: 106521553 106530770(adam17)
NWH: 119418690(adam17b) 119427330(adam17a)
MCEP: 124998878(adam17b) 125023604(adam17a)
CSEM: 103377555(adam17) 103381366
SSEN: 122782844(adam17a) 122784344(adam17b)
HHIP: 117755872(adam17a) 117758776(adam17b)
HSP: 118104017(adam17b) 118116343(adam17a)
PPLT: 128450646(adam17a) 128460522(adam17b)
SMAU: 118286480(adam17a) 118289970(adam17b)
LCF: 108888136(adam17a) 108891569(adam17b)
SLAL: 111644771(adam17) 111672592
XGL: 120788898(adam17b) 120795416(adam17a)
HCQ: 109526133(adam17) 109531720
SBIA: 133496315(adam17b) 133513442(adam17a)
PEE: 133412516(adam17a) 133417292(adam17b)
PTAO: 133468402(adam17b) 133488146(adam17a)
BPEC: 110155414(adam17) 110164254
BSPL: 114847944(adam17a) 114849978(adam17b)
SJO: 128375934(adam17a) 128377021(adam17b)
OTW: 112217454(adam17b) 112247281 112256502(adam17a)
OMY: 110498110 110505320(adam17a) 110522060(adam17b)
OGO: 123994869(adam17b) 124001138 124046303(adam17a)
SNH: 120019620(adam17b) 120023088(adam17a) 120060189
CCLU: 121539398 121545088 121566828(adam17b)
SFM: 108921884(adam17)
PKI: 111842019
AANG: 118223873 118230860(adam17b)
LOC: 102682214(adam17)
PSPA: 121315402 121317536(adam17b)
ARUT: 117402183(adam17a) 117411384(adam17b)
PSEX: 120526040(adam17b)
LCM: 102367618(ADAM17)
CMK: 103187122(adam17b)
CPLA: 122541365(adam17b)
HOC: 132834418(adam17b)
LERI: 129697077(adam17b)
PMRN: 116942526 116951388(ADAM17)
BFO: 118404014
BBEL: 109473119
CIN: 100175230
SCLV: 120332865
SPU: 585715
LPIC: 129264781
APLC: 110985040
AJC: 117103049
SKO: 102803736
DME: Dmel_CG7908(Tace)
DER: 6554190
DSE: 6612793
DSI: Dsimw501_GD21492(Dsim_GD21492)
DAN: 6501584
DSR: 110186406
DPO: 6896714
DPE: 6594801
DMN: 108155302
DWI: 6650344
DGR: 6567576
DAZ: 108609115
DNV: 108659297
DHE: 111596420
DVI: 6635224
CCAT: 101448581
BOD: 106618981
BDR: 105225774
RZE: 108361250
AOQ: 129239624
SCAC: 106081862
LCQ: 111686124
LSQ: 119601926
GFS: 119635009
ECOE: 129939823
CLON: 129607063
HIS: 119650619
AGA: 1273579
ACOZ: 120949087
AARA: 120894455
AMER: 121590638
ASTE: 118502845
AFUN: 125763313
AMOU: 128301613
AALI: 118457949
AAG: 5563722
AALB: 109424331
ASUA: 134224369
CPII: 120421188
CNS: 116346870
BCOO: 119069712
AME: 551599
ACER: 108000097
ALAB: 122717424
ADR: 102674053
AFLR: 100868051
BIM: 100745543
BBIF: 117212151
BVK: 117240411
BVAN: 117162798
BTER: 100645870
BAFF: 126914335
BPYO: 122566715
BPAS: 132909761
FVI: 122527570
CCAL: 108623713
OBB: 114877479
OLG: 117607800
MGEN: 117227229
NMEA: 116432844
CGIG: 122396464
SOC: 105197464
MPHA: 105839042
AEC: 105143101
ACEP: 105623272
PBAR: 105427116
VEM: 105561144
HST: 105184135
DQU: 106750237
CFO: 105258924
FEX: 115241593
LHU: 105669279
PGC: 109861730
OBO: 105282848
PCF: 106793988
PFUC: 122521241
VPS: 122637869
VCRB: 124422154
VVE: 124956652
NVI: 100119121
CSOL: 105364600
TPRE: 106654176
LHT: 122502437
LBD: 127289378
MDL: 103578657
CGLO: 123270939
FAS: 105266951
DAM: 107041094
AGIF: 122855408
CINS: 118073841
VCAN: 122406705
CCIN: 107265431
DSM: 124408540
NPT: 124211666
NFB: 124187719
NLO: 107226342
NVG: 124298125
AROA: 105690398
TCA: 663540
DPA: 109537991
SOY: 115875020
AGRG: 126748933
ATD: 109602707
AGB: 108914225
LDC: 111506628
DVV: 114326997
NVL: 108563900
PPYR: 116161187
OTU: 111419993
BMOR: 101742406
BMAN: 114240363
MSEX: 115440097
BANY: 112051369
MJU: 123874356
NIQ: 126773170
VCD: 124534830
MCIX: 123659170
PMAC: 106713573
PPOT: 106104922
PXU: 106122629
PRAP: 111003508
PBX: 123706897
PNAP: 125050368
CCRC: 123698644
LSIN: 126967438
AAGE: 121734141
HAW: 110384278
HZE: 124637015
TNL: 113503404
SLIU: 111354966
OFU: 114352070
ATRA: 106129617
GMW: 113510798
PXY: 105386060
PGW: 126370922
LGLY: 125234118
CFEL: 113372468
CCRN: 123305992
API: 100158671
DNX: 107167450
AGS: 114130986
RMD: 113559354
DVT: 126902802
BTAB: 109032996
DCI: 103515131
CLEC: 106673239
HHAL: 106685230
NLU: 111053184
HVI: 124361784
MQU: 128988521
FOC: 113217343
TPAL: 117654419
ZNE: 110836194
SGRE: 126267245
BROR: 134533754
IEL: 124154096
FCD: 110845600
DPZ: 124340918
HAME: 121869162
PCLA: 123764791
CQD: 128696329
PTRU: 123504923
ESN: 126996497
HAZT: 108674819
EAF: 111713207
TCF: 131877982
ISC: 120835932
DSV: 119460684
RSAN: 119396531
RMP: 119174711
CSCU: 111618821
PTEP: 107455115
ABRU: 129958549
UDV: 129230976
SDM: 118180981
PMEO: 129589025
CEL: CELE_ZK154.7(adm-4)
CBR: CBG_16796(Cbr-adm-4)
BMY: BM_BM7430(Bma-adm-4)
TSP: Tsp_02601
OBI: 106881514
OSN: 115220007
LJP: 135464594
LAK: 106153651
SHX: MS3_00006789(ADAM17)
EGL: EGR_00581
NVE: 5511423
EPA: 110250562
ATEN: 116292316
ADF: 107358831
AMIL: 114948654
PDAM: 113681067
SPIS: 111328065
DGT: 114528597
XEN: 124447472
HMG: 100210793
RES: 135689956
 » show all
Reference
PMID:9034191
  Authors
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al.
  Title
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
  Journal
Nature 385:733-6 (1997)
DOI:10.1038/385733a0
  Sequence
[hsa:6868]
Reference
  Authors
Thathiah A, Blobel CP, Carson DD
  Title
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
  Journal
J Biol Chem 278:3386-94 (2003)
DOI:10.1074/jbc.M208326200
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