Entry Name ABC transporters - Pseudomonas aeruginosa NCGM2.S1
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Pseudomonas aeruginosa NCGM2.S1 [GN:
pnc ]
Gene NCGM2_0194 atsR; putative binding protein component of ABC transporter [KO:K15553 ]
NCGM2_0294 fliY; putative binding protein component of ABC transporter [KO:K02424 ]
NCGM2_0414 proX; putative binding protein component of ABC transporter [KO:K02002 ]
NCGM2_0612 braD; putative permease of ABC branched chain amino acid transporter [KO:K01997 ]
NCGM2_0613 braE; putative permease of ABC branched-chain amino acid transporter [KO:K01998 ]
NCGM2_1933 livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
NCGM2_1934 livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
NCGM2_2230 ybeJ; putative binding protein component of ABC transporter [KO:K10001 ]
NCGM2_2292 potF; putative periplasmic spermidine/putrescine-binding protein [KO:K11073 ]
NCGM2_2864 rbsB; binding protein component precursor of ABC ribose transporter [KO:K10439 ]
NCGM2_2866 rbsC; membrane protein component of ABC ribose transporter [KO:K10440 ]
NCGM2_3346 mtlE; putative binding protein component of ABC maltose/mannitol transporter [KO:K10227 ]
NCGM2_3347 mtlF; putative binding-protein-dependent maltose/mannitol transport protein [KO:K10228 ]
NCGM2_3348 mtlG; putative binding-protein-dependent maltose/mannitol transport protein [KO:K10229 ]
NCGM2_3349 mtlk; putative ATP-binding component of ABC maltose/mannitol transporter [KO:K10111 ] [EC:7.5.2.-]
NCGM2_3359 metN-1; putative ATP-binding component of ABC transporter [KO:K02071 ]
NCGM2_3607 potF; putative periplasmic spermidine/putrescine-binding protein [KO:K11073 ]
NCGM2_3609 ssuA; putative periplasmic aliphatic sulfonate-binding protein [KO:K15553 ]
NCGM2_3739 potF4; putative periplasmic spermidine/putrescine-binding protein [KO:K11073 ]
NCGM2_4101 lolD; putative lipoprotein releasing system ATP-binding protein [KO:K09810 ] [EC:7.6.2.-]
NCGM2_4300 gltK; putative ATP-binding component of ABC transporter [KO:K10112 ] [EC:7.5.2.-]
NCGM2_4303 gltB; putative binding protein component of ABC sugar transporter [KO:K17315 ]
NCGM2_4350 bapA; putative ATP-binding/permease fusion ABC transporter [KO:K18893 ]
NCGM2_4519 phnD; binding protein component of ABC phosphonate transporter [KO:K02044 ]
NCGM2_5362 fepB; iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
NCGM2_5977 fbpA; putative binding protein component of ABC iron transporter [KO:K02012 ]
NCGM2_6135 pstC; membrane protein component of ABC phosphate transporter [KO:K02037 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
