Pongo abelii (Sumatran orangutan): 100454349
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Entry
100454349 CDS
T01416
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X3
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
pon
Pongo abelii (Sumatran orangutan)
Pathway
pon00350
Tyrosine metabolism
pon00790
Folate biosynthesis
pon01100
Metabolic pathways
pon04728
Dopaminergic synapse
pon04917
Prolactin signaling pathway
pon05012
Parkinson disease
pon05030
Cocaine addiction
pon05031
Amphetamine addiction
pon05034
Alcoholism
Module
pon_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
pon00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
100454349 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100454349 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
100454349 (TH)
09156 Nervous system
04728 Dopaminergic synapse
100454349 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100454349 (TH)
09165 Substance dependence
05030 Cocaine addiction
100454349 (TH)
05031 Amphetamine addiction
100454349 (TH)
05034 Alcoholism
100454349 (TH)
Enzymes [BR:
pon01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
100454349 (TH)
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Gene cluster
GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
100454349
NCBI-ProteinID:
XP_024110669
Ensembl:
ENSPPYG00000002924
UniProt:
H2NCG1
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All DBs
Position
9:complement(2155210..2164234)
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AA seq
528 aa
AA seq
DB search
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAAPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRLRAGGPHLEYFVRLEVPRGDLATLLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
NT seq
1587 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccgacgctaccacgccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatggtaagagggcagggggccccggggcccagc
ctcacaggctctccatggcctggaactgcagccccagctgcatcctacacccccacccca
aggtccccgcggttcattgggcggaggcagagcctcatcgaggacgcccgcaaggagcgg
gaggcggcggtggcagcggcggccgctgcagccccctcggagcccggggaccccctggag
gccgtggcctttgaggagaaggaggggaaggccgtgctaaacctgctcttctccccgagg
gccaccaagccctcggcgctgtcccgagctgtgaaggtgtttgagacgtttgaagccaaa
atccaccatctagagacccggcctgcccagaggctgcgagctgggggcccccacctggag
tacttcgtgcgcctcgaggtgccccgaggggacctggccaccctgctcagtggtgtgcgc
caggtgtcagaggacgtgcgcagccctgcggggcccaaggtcccctggttcccaagaaaa
gtgtcagagctggacaagtgtcatcacctggtcaccaagttcgaccctgacctggacttg
gaccacccgggcttctcggaccaggtgtaccgccagcgcaggaagctgattgctgagatc
gccttccagtacaggcacggcgacccgattccccgtgtggagtacaccgccgaggagatt
gccacctggaaggaggtctacaccacgctgaagggcctctacgccacgcacgcctgcggg
gagcacctggaggcctttgctttgctggagcgcttcagcggctatcgggaagacaatatc
cctcagctggaggacgtctcccgcttcctgaaggagcgcacgggcttccagctgcggcct
gtggccggcctgctgtccgcccgggactttctggccagcctggccttccgcgtgttccag
tgcacccagtatatccgccacgcgtcctcgcccatgcactcccctgagccggactgctgc
cacgagctgctggggcacgtgcccatgctggcagaccgcaccttcgcgcagttctcgcag
gacattggcctggcgtccctgggggcctcggatgaggaaattgagaagctgtccacgctg
tactggttcacggtggagtttgggctgtgtaagcagaacggggaggtgaaggcctacggc
gcagggctgctgtcctcctacggggagctcctgcattgcctgtctgaggagcccgagatt
cgggccttcgaccctgaagctgcggccgtgcagccctaccaagaccagacataccagtca
gtctacttcgtgtctgagagcttcagtgacgccaaggacaagctcaggagctatgcctca
cgcatccagcgccccttctccgtgaagttcgacccatacacgctggccatcgacgtgctg
gacagcccccaggccgtgcggcgctccctggagggtgtccaggacgagctggacaccctt
gcccatgcgctgagtgccattggctag
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