KEGG   PATHWAY: ppeg03070
Entry
ppeg03070                   Pathway                                
Name
Bacterial secretion system - Pseudomonas pergaminensis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ppeg03070  Bacterial secretion system
ppeg03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas pergaminensis [GN:ppeg]
Gene
KUA23_10830  TolC family protein [KO:K12340]
KUA23_02515  TolC family outer membrane protein [KO:K12340]
KUA23_22450  sctC; type III secretion system outer membrane ring subunit SctC [KO:K03219]
KUA23_03840  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
KUA23_10925  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
KUA23_03785  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
KUA23_10955  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
KUA23_03790  sctS; type III secretion system export apparatus subunit SctS [KO:K03227]
KUA23_10960  flagellar biosynthetic protein FliQ [KO:K03227]
KUA23_03795  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
KUA23_10965  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
KUA23_03800  sctU; type III secretion system export apparatus subunit SctU [KO:K03229]
KUA23_10970  EscU/YscU/HrcU family type III secretion system export apparatus switch protein [KO:K03229]
KUA23_03755  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
KUA23_10890  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
KUA23_03765  FliI/YscN family ATPase [KO:K03224] [EC:7.4.2.8]
KUA23_10940  FliI/YscN family ATPase [KO:K03224] [EC:7.4.2.8]
KUA23_03780  FliM/FliN family flagellar motor switch protein [KO:K03225]
KUA23_10950  sctQ; type III secretion system cytoplasmic ring protein SctQ [KO:K03225]
KUA23_10935  HrpE/YscL family type III secretion apparatus protein [KO:K03223]
KUA23_18120  gspD; type II secretion system secretin GspD [KO:K02453]
KUA23_19945  gspD; type II secretion system secretin GspD [KO:K02453]
KUA23_18150  general secretion pathway protein GspC [KO:K02452]
KUA23_18110  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
KUA23_19990  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
KUA23_18140  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
KUA23_19985  type II secretion system protein GspG [KO:K02456]
KUA23_18155  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
KUA23_19980  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02457]
KUA23_18145  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
KUA23_19975  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02458]
KUA23_18160  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
KUA23_19970  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02459]
KUA23_18135  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
KUA23_19965  general secretion pathway protein GspK [KO:K02460]
KUA23_19960  PilN domain-containing protein [KO:K02461]
KUA23_18130  type II secretion system protein GspL [KO:K02461]
KUA23_19955  type II secretion system protein M [KO:K02462]
KUA23_18125  type II secretion system protein M [KO:K02462]
KUA23_18115  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
KUA23_19995  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
KUA23_28710  GspE/PulE family protein [KO:K02454] [EC:7.4.2.8]
KUA23_24895  secD; protein translocase subunit SecD [KO:K03072]
KUA23_24890  secF; protein translocase subunit SecF [KO:K03074]
KUA23_27040  secE; preprotein translocase subunit SecE [KO:K03073]
KUA23_25680  secG; preprotein translocase subunit SecG [KO:K03075]
KUA23_26875  secY; preprotein translocase subunit SecY [KO:K03076]
KUA23_24900  yajC; preprotein translocase subunit YajC [KO:K03210]
KUA23_30045  yidC; membrane protein insertase YidC [KO:K03217]
KUA23_08555  YidC/Oxa1 family membrane protein insertase [KO:K03217]
KUA23_24210  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
KUA23_28275  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
KUA23_01705  secB; protein-export chaperone SecB [KO:K03071]
KUA23_24595  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
KUA23_01930  twin-arginine translocase TatA/TatE family subunit [KO:K03116]
KUA23_01925  tatB; Sec-independent protein translocase protein TatB [KO:K03117]
KUA23_01920  tatC; twin-arginine translocase subunit TatC [KO:K03118]
KUA23_02320  type VI secretion system tip protein VgrG [KO:K11904]
KUA23_10355  type VI secretion system tip protein VgrG [KO:K11904]
KUA23_29485  type VI secretion system tip protein VgrG [KO:K11904]
KUA23_16905  Hcp family type VI secretion system effector [KO:K11903]
KUA23_29460  type VI secretion system tube protein Hcp [KO:K11903]
KUA23_16855  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
KUA23_29435  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
KUA23_16840  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
KUA23_29420  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
KUA23_16845  icmH; type IVB secretion system protein IcmH/DotU [KO:K11892]
KUA23_29425  DotU family type VI secretion system protein [KO:K11892]
KUA23_16870  AAA family ATPase [KO:K11907]
KUA23_29480  tssH; type VI secretion system ATPase TssH [KO:K11907]
KUA23_29405  serine/threonine-protein kinase [KO:K11912] [EC:2.7.11.1]
KUA23_29440  tagH; type VI secretion system-associated FHA domain protein TagH [KO:K11913]
KUA23_16835  serine/threonine-protein phosphatase [KO:K11915] [EC:3.1.3.16]
KUA23_29410  protein phosphatase 2C domain-containing protein [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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