KEGG   Pan paniscus (bonobo): 100986388
Entry
100986388         CDS       T02283                                 
Symbol
AKR1C3
Name
(RefSeq) aldo-keto reductase family 1 member C3 isoform X2
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00140  Steroid hormone biosynthesis
pps00590  Arachidonic acid metabolism
pps00790  Folate biosynthesis
pps01100  Metabolic pathways
pps04913  Ovarian steroidogenesis
pps05208  Chemical carcinogenesis - reactive oxygen species
Module
pps_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pps_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100986388 (AKR1C3)
   00590 Arachidonic acid metabolism
    100986388 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    100986388 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100986388 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    100986388 (AKR1C3)
Enzymes [BR:pps01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     100986388 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     100986388 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     100986388 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     100986388 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 100986388
NCBI-ProteinID: XP_034785765
Ensembl: ENSPPAG00000028592
UniProt: A0A2R9A0L9
LinkDB
Position
8:17590820..17668960
AA seq 323 aa
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTAEDMKAIDGLD
RNLRYFNSDSLASHPNYPYSDEY
NT seq 972 nt   +upstreamnt  +downstreamnt
atggattccaaacaccagtgtgtgaagctaaatgatggccacttcatgcctgtattggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaaaagagaagacatattc
tacacttcaaagctttggtccacttttcatcgaccagagttggtccgaccagccttggaa
aactcgctgaaaaaagctcaattggactatgttgacctctatcttattcattctccaatg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcaaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggttctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagagagaat
gtccaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccgctattttaacagtgatagtcttgctagccaccctaattatccatattca
gatgaatattaa

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