Pongo pygmaeus (Bornean orangutan): 129007931
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Entry
129007931 CDS
T10128
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X2
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
ppyg Pongo pygmaeus (Bornean orangutan)
Pathway
ppyg00350
Tyrosine metabolism
ppyg00790
Folate biosynthesis
ppyg01100
Metabolic pathways
ppyg04728
Dopaminergic synapse
ppyg04917
Prolactin signaling pathway
ppyg05012
Parkinson disease
ppyg05030
Cocaine addiction
ppyg05031
Amphetamine addiction
ppyg05034
Alcoholism
Module
ppyg_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
ppyg00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
129007931 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
129007931 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
129007931 (TH)
09156 Nervous system
04728 Dopaminergic synapse
129007931 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
129007931 (TH)
09165 Substance dependence
05030 Cocaine addiction
129007931 (TH)
05031 Amphetamine addiction
129007931 (TH)
05034 Alcoholism
129007931 (TH)
Enzymes [BR:
ppyg01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
129007931 (TH)
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Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
129007931
NCBI-ProteinID:
XP_054295327
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Position
9:complement(2172275..2180155)
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AA seq
528 aa
AA seq
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MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAAPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRLRAGGPHLEYFVRLEVPRGDLATLLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
NT seq
1587 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccgacgctaccacgccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatggtaagagggcagggggccccggggcccagc
ctcacaggctctccatggcctggaactgcagccccagctgcatcctacacccccacccca
aggtccccgcggttcattgggcggaggcagagcctcatcgaggacgcccgcaaggagcgg
gaggcggcggtggcagcggcggccgctgcagccccctcggagcccggggaccccctggag
gccgtggcctttgaggagaaggaggggaaggccgtgctaaacctgctcttctccccgagg
gccaccaagccctcggcgctgtcccgagctgtgaaggtgtttgagacgtttgaagccaaa
atccaccatctagagacccggcctgcccagaggctgcgagctgggggcccccacctggag
tacttcgtgcgcctcgaggtgccccgaggggacctggccaccctgctcagtggtgtgcgc
caggtgtcagaggacgtgcgcagccctgcggggcccaaggtcccctggttcccaagaaaa
gtgtcagagctggacaagtgtcatcacctggtcaccaagttcgaccctgacctggacttg
gaccacccgggcttctcggaccaggtgtaccgccagcgcaggaagctgattgctgagatc
gccttccagtacaggcacggcgacccgattccccgtgtggagtacaccgccgaggagatt
gccacctggaaggaggtctacaccacgctgaagggcctctacgccacgcacgcctgcggg
gagcacctggaggcctttgctttgctggagcgcttcagcggctatcgggaagacaatatc
cctcagctggaggacgtctcccgcttcctgaaggagcgcacgggcttccagctgcggcct
gtggccggcctgctgtccgcccgggactttctggccagcctggccttccgcgtgttccag
tgcacccagtatatccgccacgcgtcctcgcccatgcactcccctgagccggactgctgc
cacgagctgctggggcacgtgcccatgctggcagaccgcaccttcgcgcagttctcgcag
gacattggcctggcgtccctgggggcctcggatgaggaaattgagaagctgtccacgctg
tactggttcacggtggagtttgggctgtgtaagcagaacggggaggtgaaggcctacggc
gcagggctgctgtcctcctacggggagctcctgcattgcctgtctgaggagcccgagatt
cgggccttcgaccctgaagctgcggccgtgcagccctaccaagaccagacataccagtca
gtctacttcgtgtctgagagcttcagtgacgccaaggacaagctcaggagctatgcctca
cgcatccagcgccccttctccgtgaagttcgacccatacacgctggccatcgacgtgctg
gacagcccccaggccgtgcggcgctccctggagggtgtccaggacgagctggacaccctt
gcccatgcgctgagtgccattggctag
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