Plasmodium relictum: PRELSG_0512500
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Entry
PRELSG_0512500 CDS
T09405
Symbol
DHFR-TS
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase, putative
KO
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
Organism
prel
Plasmodium relictum
Pathway
prel00240
Pyrimidine metabolism
prel00670
One carbon pool by folate
prel00790
Folate biosynthesis
prel01100
Metabolic pathways
prel01232
Nucleotide metabolism
prel01240
Biosynthesis of cofactors
Module
prel_M00841
Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
prel_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:
prel00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
PRELSG_0512500 (DHFR-TS)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
PRELSG_0512500 (DHFR-TS)
00670 One carbon pool by folate
PRELSG_0512500 (DHFR-TS)
Enzymes [BR:
prel01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
PRELSG_0512500 (DHFR-TS)
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
PRELSG_0512500 (DHFR-TS)
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Gene cluster
GFIT
Motif
Pfam:
Thymidylat_synt
DHFR_1
ANC1_spectrin
Motif
Other DBs
NCBI-GeneID:
39735068
NCBI-ProteinID:
XP_028531976
UniProt:
A0A1J1H340
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Position
5:420560..422335
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AA seq
591 aa
AA seq
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MSEISHIFDIHAICACCKVENKNEKKKNEVFNNNTFRGIGNKCDLPWKSIPLDMKYFTTV
TTYVDESKYGKLKYKREKYLEKTANDTNYLENIMQSSNNLQNVVVMGRTSWESIPKKYKP
LDNRINVVLSKTLKKEDIKEDDVIVINNVDDLLLLLRKLKYYKCFIIGGAIVYNEFLQRN
LIKKIYFTRINSTYECDVFFPEIKDTEYEITSLSDVYNYKGVTLNFVIYKRKKELLNNRN
LNEYNKETDRYFLDIPNNCFNGKNDYKNIDDEDDYVYFNFINTKEKKNFEACEDFKIYNS
LKYKYHPEYQYLNIVYDVITSGNKQNDRTGVGILSKFGYMMKFDLSQYFPLLTTKKVFIR
GIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHF
GAEYTNMHDNYENKGIDQLKNIINLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFY
VFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQPAQFIHILGNAHVYNNHV
DSLKKQLNRIPYPFPTLKLNPDIKNIEDFTCSDFTIENYVHHDKISMDMAA
NT seq
1776 nt
NT seq
+upstream
nt +downstream
nt
atgagtgaaatatcgcatattttcgatatacatgccatatgtgcttgttgtaaagttgaa
aacaaaaatgagaagaaaaaaaatgaagttttcaataataatacatttagaggaattggg
aataagtgtgatttgccttggaaaagtatcccattagacatgaaatattttactacagta
actacgtatgttgatgaatcaaaatatggaaaattgaaatataaaagagagaaatattta
gaaaaaacagcaaacgatacaaattatttagaaaatataatgcaatcatcaaataattta
caaaatgttgtagttatgggaagaactagctgggaaagcattccaaaaaaatataagcca
ttagataatagaataaatgttgtattatcaaaaacactaaaaaaagaagacataaaagaa
gatgatgttattgtaattaataatgtggatgatttgcttctactattaagaaaattaaaa
tattacaaatgttttattattggtggtgcaattgtatacaatgaatttttacaaagaaat
ttaataaaaaaaatttattttacaagaataaatagcacatatgaatgtgatgtttttttt
ccagaaattaaggatacagaatatgaaattacatctctaagcgatgtgtataactataaa
ggcgtaacattaaactttgtaatttataagagaaaaaaagaattattaaataatagaaac
ctcaatgaatataataaagaaacagatagatattttttagatatcccaaataattgtttc
aatggaaagaatgattataaaaatatagatgatgaagatgattatgtatattttaatttt
attaatacaaaagaaaaaaaaaatttcgaagcatgtgaagattttaaaatatataatagc
ttgaaatataagtatcatcctgaatatcaatatttaaatattgtatatgatgttattacg
agtgggaataagcaaaatgatagaactggtgtaggaatattaagtaagtttggatacatg
atgaaatttgatttaagtcaatattttcctttattgacaaccaaaaaagtgttcataaga
ggaatcatagaagaattactttggtttataagaggggaaactaatggaaatactttgttg
aataaaaacgtaagaatatgggaagctaatggaacaagggaatttctagataatagaaaa
ttattcgatagagaagttaatgatttgggacccatttatggttttcaatggagacatttc
ggtgctgaatacactaatatgcatgataattatgaaaataagggaatagatcaattaaaa
aatatcatcaatttaataaaaaatgagcccactagtagaagaattattttatgcgcatgg
aatgtaaaagatttggatcaaatggcattgccaccttgccatattttatgtcaattttat
gtctttgatggaaaattatcgtgcattatgtatcagaggtcatgtgatttgggattagga
gtcccttttaatattgcatcatattcaatttttacttatatgattgctcaagtgtgcaat
ttacaacctgcacagttcatacatattttgggaaatgcacatgtatataacaatcatgta
gatagcttaaaaaaacaattaaacagaataccttatccttttccaactcttaaattaaat
ccagatataaagaatattgaagactttacgtgttccgattttacaatagaaaattatgtg
catcatgataaaatttctatggatatggccgcataa
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