Pan troglodytes (chimpanzee): 100612063 Help Entry 100612063         CDS       T01005                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 isoform X4   KO K04961   ryanodine receptor 1 Organism ptr  Pan troglodytes (chimpanzee) Pathway ptr04020   Calcium signaling pathway ptr04371   Apelin signaling pathway ptr04713   Circadian entrainment ptr04730   Long-term depression ptr04921   Oxytocin signaling pathway ptr05017   Spinocerebellar ataxia ptr05020   Prion disease ptr05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:ptr00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100612063 (RYR1)    04020 Calcium signaling pathway     100612063 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100612063 (RYR1)   09156 Nervous system    04730 Long-term depression     100612063 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     100612063 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     100612063 (RYR1)    05020 Prion disease     100612063 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     100612063 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:ptr01009]     100612063 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ptr04147]     100612063 (RYR1)    04040 Ion channels [BR:ptr04040]     100612063 (RYR1) Protein phosphatases and associated proteins [BR:ptr01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100612063 (RYR1) Exosome [BR:ptr04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100612063 (RYR1) Ion channels [BR:ptr04040]  Voltage-gated cation channels   Ryanodine receptor    100612063 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  100612063 NCBI-ProteinID:  XP_009433809 Ensembl:  ENSPTRG00000010931 ENSPTRG00000050119 VGNC:  7491 UniProt:  A0A2I3TTJ6 LinkDB All DBs Position 20:41560404..41718866 Genome browser AA seq 5037 aa AA seqDB search MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGRYLALTEDQGLVV VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV SFSAGVRVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED EARAAEPDPDYENLRRSAGGRGEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK QILKMIEPEVFTEEEEEEDEEEEEDEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGL LIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL AHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVS HMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECL GQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGE SKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAAS VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAV FVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRR DRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRS LVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLL HVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMV DSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKM PLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMA MPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFA EYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAW EWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLA ENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR GLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFA KILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTK NTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEM CPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAG APPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFI PTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNN RAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMA KAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTR YALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEV SAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKA VWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDED YLYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKEMEKQRLLYQQARLHTRGAAEMVL QMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCS VLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQ NYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQ VFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQ KDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDY VTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIG FNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISET NRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPET DEDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRR LRRLTAREAATAVAALLWAAVTRAGAAAAGAAAGALGLLWGSLFGGGLVEGAKKVTVTEL LAGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVA VTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPELEP EKADAENGEKEEVPEPPPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFY TLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGGSGWGLGAGEEAE GDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARK LEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAEL LGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSL LGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITF FFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTL EEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15114 nt NT seq  +upstreamnt  +downstreamnt atgggtgacgcagaaggcgaagacgaggtccagttcctgcggacggacgatgaggtggtc ctgcagtgcagcgctaccgtgctcaaggagcagctcaagctctgcctggccgccgagggc ttcggcaaccgcctgtgcttcctggagcccactagcaacgcgcagaatgtgccccccgat ctggccatctgttgcttcgtcctggagcagtccctgtccgtgcgagccctgcaggagatg ctggctaacacggtggaggctggcgtggagtcatcccagggcgggggacacaggacgctc ctgtatggccatgccatcctgctccggcatgcacacagccgcatgtatctgagctgcctc accacctcccgctccatgactgacaagctggccttcgatgtgggactgcaggaggacgca acaggagaggcttgctggtggaccatgcacccagcctccaagcagaggtctgaaggagaa aaggtccgcgttggggatgacatcatccttgtcagcgtctcctccgagcgctacctgcac ctgtcgaccgccagtggggagctccaggttgatgcttccttcatgcagacactgtggaac atgaaccccatctgctcccgctgcgaagagggcttcgttacgggaggtcacgtcctccgc ctctttcatggacatatggatgagtgtctgaccatttcccctgctgacagtgatgaccag cgcagacttgtctactatgaggggggagctgtgtgcacccacgcccgctccctctggagg ctggagccactgagaatcagctggagtgggagccacctgcgctggggccagccactccga gtccggcatgtcaccaccgggcggtacctagcgctcaccgaggaccagggcctggtggtg gttgacgccagcaaggctcacaccaaggctacctccttctgcttccgcatctccaaggag aagctggatgtggcccccaagcgggatgtggagggcatgggcccccctgagataaagtac ggggagtcactgtgcttcgtgcagcatgtggcctcaggactgtggctcacctatgccgct ccagaccccaaggccctgcggctcggcgtgctcaagaagaaggccatgctgcaccaggag ggccacatggacgacgcactgtcgctgacccgctgccagcaggaggagtcccaggccgcc cgcatgatccacagcaccaatggcctatacaaccagttcatcaagagcctggacagcttc agcgggaagccacggggctcggggccacccgctggcacggcgctgcccatcgagggcgtt atcctgagcctgcaggacctcatcatctactttgagcctccctccgaggacttgcagcac gaggagaagcagagcaagctgcgaagcctgcgcaaccgccagagcctcttccaggaggag gggatgctctccatggtcctgaattgcatagaccgcctaaatgtctacaccactgctgcc cactttgctgagtttgcaggggaggaggcagccgagtcctggaaagagattgtgaatctt ctctatgaactcctagcttctctaatccgtggcaatcgtagcaactgtgccctcttctcc acaaacttggactggctggtcagcaagctggatcggctggaggcctcgtctggcatcctg gaggtcctgtactgtgtcctcattgagagtccggaggttctgaacatcatccaggagaat cacatcaagtccatcatctccctcctggacaagcatgggaggaaccacaaggtcctggac gtgctatgctccctgtgtgtgtgtaatggtgtggctgtacgctccaaccaagatcttatt actgagaacttgctgcctggccgtgagcttctgctgcagacaaacctcatcaactatgtc accagcatccgccccaacatctttgtgggccgagcggaaggcaccacgcagtacagcaaa tggtactttgaggtgatggtggacgaggtgactccatttctgacagctcaggccacccac ttgcgggtgggctgggccctcaccgagggctacaccccctaccctggggccggcgagggc tggggcggcaacggggtcggcgatgacctctattcctacggctttgatggactgcatctc tggacaggacacgtggcacgcccggtgacttccccagggcagcacctcttggcccctgaa gatgtgatcagctgctgcctggacctcagtgtgccgtccatctccttccgcatcaacggc tgccccgtgcagggtgtctttgagtccttcaacctggacgggctcttcttccctgttgtc agcttctcggctggtgtcagggtgcggttcctccttggtggccgccatggtgaattcaag ttcctgcccccacctggctatgctccatgccatgaggctgtgctccctcgagagcgactc catcttgaacccatcaaggagtatcgacgggaggggccccgggggcctcacctggtgggc cccagtcgctgcctctcacacaccgacttcgtgccctgccctgtggacactgtccagatt gtcctgccgccccatctggagcgcattcgggagaagctggcggagaacatccacgagctc tgggcgctaacccgcatcgagcagggctggacctacggcccggttcgggatgacaacaag aggctgcacccgtgtcttgtggacttccacagccttccagagcctgagaggaactacaac ctgcagatgtctggggagacgctcaagactctgctggctctgggctgccacgtgggcatg gcggatgagaaggcggaggacaacctgaagaagacaaaactccccaagacgtatatgatg agcaatgggtacaagccggctccgctggacctgagccatgtgcggctgacaccggcgcag acgacactggtggaccgtctggcagaaaatgggcacaacgtgtgggcccgagaccgcgtg ggccagggctggagctacagcgcagtgcaggacatcccagcgcgccgaaaccctcggctg gtgccctaccgcctgctggacgaagccaccaagcgcagcaaccgggacagcctctgccag gccgtgcgcaccctcctgggctacggctacaacatcgagcctcctgaccaggagcccagt caggtggagaaccagtctcgctgtgaccgggtgcgcatcttccgggcagagaaatcctat acagtgcagagcggccgctggtacttcgagtttgaagcagtcaccacaggcgagatgcga gtgggctgggcgaggcccgagctgaggcctgatgtagagctgggagctgacgagctggcc tatgtcttcaatgggcaccgtggccagcgctggcacttgggcagtgaaccatttgggcgc ccctggcagccgggcgatgtcgttggctgtatgatcgacctcacagagaacaccattatc ttcaccctcaatggcgaggtcctcatgtctgactcaggctccgaaacagccttccgggag attgagattggggacggcttcctgcccgtctgcagcttgggacctggccaggtgggtcat ctgaacctgggccaggacgtgagctctctgaggttctttgccatctgtggcctccaggaa ggcttcgagccatttgccatcaacatgcagcgcccagtcaccacctggttcagcaaaggc ctgccccagtttgagccagtgccccttgaacaccctcactatgaggtatcccgagtggac ggcactgtggacacgcccccctgcctgcgcctgacccaccgcacctggggctcccagaac agcctggtggagatgctcttcctgcggctgagcctcccagtccagttccaccagcacttc cgctgcactgcaggggccaccccgctggcacctcctggcctgcagccccccgccgaggac gaggcccgggcggcggaacccgaccctgactacgaaaacctgcgccgctcagctgggggc cggggcgaggcagagaacggcaaagaagggactgcgaaggagggcgcccccgggggcacc ccgcaggcggggggagaggcgcagccggccagggcggagaatgagaaggacgccaccacc gagaagaacaagaagagaggcttcttattcaaggccaagaaggtcgccatgatgacccag ccaccggccacccccacgctgccccgactccctcacgacgtggtgcctgcagacaaccgc gatgaccccgagatcatcctcaacaccaccacgtactattactctgtgagggtctttgcc ggacaggagcccagctgcgtgtgggcgggctgggtcacccctgactaccatcagcacgac atgagcttcgacctcagcaaggtccgggtcgtgacggtgaccatgggggatgaacaaggc aacgtccacagcagcctcaagtgtagcaactgctacatggtgtggggcggagactttgtg agtcccgggcagcagggccggatcagccacacggaccttgtcattgggtgcctggtggac ttggccactggcttaatgacctttacagccaatggcaaagagagcaacacctttttccag gtggaacccaacacaaagctatttcctgccgtcttcgtcctgcccacccaccagaacgtc atccagtttgagctggggaagcagaagaacatcatgccgttgtcagccgccatgttccaa agcgagcgcaagaacccggccccgcagtgcccaccgcggctggagatgcagatgctgatg ccagtgtcctggagccgcatgcccaaccacttcctgcaggtggagacgaggcgtgccggc gagcggctgggctgggccgtgcagtgccaggagccgctgaccatgatggcgctgcacatc cccgaggagaaccggtgcatggacatcctggagctgtcggagcgcctggacctgcagcgc ttccactcgcacaccctgcgcctctaccgcgctgtgtgcgccctgggcaacaatcgcgtg gcgcacgctctgtgcagccacgtagaccaagctcagctgctgcacgccctggaggacgcg cacctgccaggcccactgcgcgcaggctactatgacctcctcatcagcatccacctcgaa agtgcctgccgcagccgccgctccatgctctctgaatacatcgtgcccctcacgcctgag acccgcgccatcacgctcttccctcctggaaggagcacagaaaatggtcacccccggcat ggcctgccgggagttggagtcaccacttcgctgaggcccccgcatcatttctcgcccccc tgtttcgtggccgctctgccagctgctggggcagcagaggccccggcccgcctcagccct gccatcccgctggaggccctgcgggacaaggcactgaggatgctgggggaggcggtgcgc gacggtgggcagcacgctcgcgaccccgtcgggggctccgtggagttccagtttgtgcct gtgctcaagctcgtgtccaccctgctggtgatgggcatctttggcgatgaggatgtgaaa cagatcttgaagatgattgagcctgaagtcttcactgaggaagaagaggaggaggacgag gaggaggaagaggatgaagaggaagatgaggaggagaaggaggaggatgaggaggaaaca gcacaggaaaaggaagatgaggaaaaagaggaagaggaggcagcagaaggggagaaagaa gaaggcttggaggaagggctgctccagatgaagttgccagagtctgtgaagttacagatg tgccacctgctggagtatttctgtgaccaagagttgcagcaccgtgtggagtccctggca gcctttgcggagcgctatgtggacaagctccaggccaaccagcggagccgctatggcctc ctcataaaagccttcagcatgaccgcagcagagactgcaagacgtacccgcgagttccgc tccccaccccaggaacagatcaatatgctattgcagttcaaagatggtacagatgaggaa gactgtcctctccctgaagagattcgacaggatttgcttgactttcatcaagacctgctg gcacactgtggaattcagctggatggagaggaggaggaaccagaggaagagaccaccctg ggcagccgcctcatgagcctgttggagaaagtgcggctggtgaagaagaaggaagagaaa cctgaggaggagcggtcagcagaggagagcaaaccccggtccctgcaggagctggtgtcc cacatggtggtgcgctgggcccaagaggacttcgtgcagagccccgagctggtgcgggcc atgttcagcctcctgcaccggcagtacgacgggctgggtgagctgctgcgtgccctgccg cgggcgtacaccatctcaccatcctccgtggaagacaccatgagcctgctcgagtgcctc ggccagatccgctcgctgctcatcgtgcagatgggcccccaggaggagaacctcatgatc cagagcatcgggaacatcatgaacaacaaagtcttctaccaacacccgaacctgatgagg gcgctgggcatgcacgagacggtcatggaggtcatggtcaatgtcctcgggggtggcgag tccaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgctatttc tgccgaatcagccggcagaaccagcgctccatgtttgaccacctgagctacctgctggag aacagtggcatcggcctgggcatgcagggctccacgcccctggacgtggctgctgcctcc gtcattgacaacaatgagctggccttggcattgcaggagcaggacctggaaaaggttgtg tcctacctggcaggctgtggcctccagagctgccccatgcttgtggccaaagggtaccca gacattggctggaacccctgtggtggagagcgctacctggacttcctgcgctttgctgtc ttcgtcaacggtgagagcgtggaggagaacgccaatgtggtggtgcggctgctcatccgg aagcctgagtgcttcggacccgccctgcggggtgagggtggctcagggctgctggctgcc atcgaagaggccatccgcatctccgaggaccctgcgagggatggcccaggcatccgcagg gaccggcggcgcgagcactttggtgaggaaccgcctgaagaaaaccgggtgcacctggga cacgccatcatgtccttctatgccgccttgatcgacctgctcggacgctgtgcaccagag atgcatctaatccaagccggcaagggtgaggccctgcggatccgcgccatcctccgctcc cttgtgcccttggaggaccttgtgggcatcatcagcctcccactgcagattcccaccctg ggcaaagatggggctctggtgcagccaaagatgtcagcatccttcgtgccggaccacaag gcatccatggtgctcttcctggaccgtgtgtatggcatcgagaaccaggacttcttgctg cacgtgctggacgtggggttcctgcccgacatgagggcagccgcctcgctggacacggcc actttcagcaccaccgagatggcgctggcgctgaaccgctacctgtgcctggccgtgctg ccgctcatcaccaagtgtgctccgctctttgcgggcacagaacaccgcgccatcatggtg gactctatgctgcataccgtgtaccgcctgtctcggggtcgttcgctcaccaaggcgcag cgtgacgtcatcgaggactgcctcatgtcgctctgcaggtacatccgcccgtcgatgctg cagcacctgttgcgccgcctggtgttcgacgtgcccatcctcaacgagtttgccaagatg ccactcaagctcctcaccaaccactatgagcgctgttggaagtactactgcctacccaca ggctgggccaacttcggggtcacctcagaggaggagctgcacctcacacggaaactcttc tggggcatctttgactctctggcccataagaaatacgacccggagctgtaccgcatggcc atgccttgtctgtgcgccatcgccggggctctgccccccgactatgtggatgcgtcatac tcatctaaggcagagaaaaaggccacagtggacgctgaaggcaactttgatccccggccc gtggagaccctcaatgtgatcatcccggagaagctggactccttcattaacaagtttgcg gagtacacacacgagaagtgggccttcgacaagatccagaacaactggtcctatggagag aacatagacgaggagctgaagacccaccccatgctgaggccctacaagaccttttcagag aaggacaaagagatttaccgctggcccatcaaggagtccctgaaggccatgattgcctgg gaatggacgatagagaaggccagggagggtgaggaggagaagacggaaaagaaaaaaacg cggaagatatcacaaagtgcccagacctatgatcctcgagaaggctacaaccctcagccc cccgaccttagcgctgttaccctgtcccgggagctgcaggccatggcagaacaactggca gaaaattaccacaacacgtggggacggaagaagaagcaggagctggaagccaaaggcggt gggacccaccccctgctggtcccctacgacacgctcacggccaaggagaaggcacgagat cgagagaaggcccaggagctactgaaattcctgcagatgaacggctacgcggttacaaga ggccttaaggacatggaactggactcgtcttccattgaaaagcggtttgcctttggcttc ctgcagcagctgctgcgctggatggacatttctcaggagttcattgcccacctggaggct gtggtcagcagtgggcgagtggaaaagtccccacatgaacaggagattaaattctttgcc aagatcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcttgtcc actccggctaaagtgctgggcagcggtggccacgcctctaacaaggagaaggaaatgatc accagcctcttctgcaaacttgctgctctcgtccgccaccgagtctctctctttgggacg gacgccccggctgtggtcaactgtcttcacatcctggcccgctccctggatgccaggaca gtgatgaagtcaggccctgagatcgtgaaggctggcctccgctccttcttcgagagtgcc tcggaggacatcgagaagatggtggagaacctgcggctgggcaaggtgtcgcaggcgcgc acccaggtgaaaggcgtgggccagaacctcacctacaccactgtggcactgctgccggtc ctcaccaccctcttccagcacatcgcccagcaccagttcggagatgacgtcatcctggac gacgtccaggtctcttgctaccgaacgctgtgcagtatctactccctgggaaccaccaag aacacttatgtggaaaagcttcggccagccctcggggagtgcctggcccgtctggcagca gccatgccggtggcgttcctggagccgcagctgaacgagtacaacgcctgctccgtgtac accaccaagtctccgcgggagcgggccatcctggggctccccaacagtgtggaggagatg tgtcccgacatcccggtgctggagcggctcatggcagacatcggggggctggccgagtca ggtgcccgctacacagagatgccgcacgtcatcgagatcacgctgcccatgctatgcagc tacctgccccgatggtgggagcgcgggcccgaggcaccccctcccgccctgcccgccggt gcccccccaccctgcacagctgtcacctctgaccacctcaactccctgctggggaatatc ctgagaatcatcgtcaacaacctgggcattgacgaggcctcctggatgaagcggctggct gtgttcgcacagcccattgtgagccgtgcacggccggagctcctgcagtcccacttcatc ccaactatcgggcggctgcgcaagagggcagggaaggtggtgtccgaggaggagcagctg cgcctggaggccaaggcggaggcccaggagggcgagctgctggtgcgggacgagttctcc gtgctctgccgggacctctacgccctgtatccgctgctcatccgctacgtggacaacaac agggcgcagtggctgacggagccgaatcccagcgcggaggagctgttcaggatggtgggc gagatcttcatctactggtccaagtcccacaacttcaagcgcgaggagcagaactttgtg gtccagaatgagatcaacaacatgtccttcctgactgctgacaacaaaagcaaaatggct aaggcgggagatatacagtccggtggctcggaccaggaacgcaccaagaagaagcgccgg ggggaccggtactctgtgcagacgtcactgatcgtggccacactgaagaagatgctgccc atcggcctgaatatgtgtgcgcccaccgaccaagacctcatcacgctggccaagacccgc tacgccctgaaagacacagatgaggaggtccgggaatttctgcacaacaaccttcacctt cagggaaaggtcgaaggctccccgtctctgcgctggcagatggctctgtaccggggcgtc ccgggtcgcgaggaggacgccgatgaccccgagaaaatcgtgcgcagagtccaggaagtg tcagccgtgctctactacctggaccagaccgagcacccttacaagtctaagaaggccgtg tggcacaagcttttgtccaaacagcgccggcgggcagtcgtggcctgtttccgtatgacg cccctgtacaacctgcccacgcaccgggcatgtaacatgttcctggagagctacaaggct gtatggatcctgactgaagaccacagttttgaggaccgcatgatagatgacctttcaaaa gctggggagcaggaggaggaggaggaagaggtggaagagaagaagccagaccccctgcac cagttggtcctgcacttcagccgcactgccctgacggaaaagagcaaactggacgaggat tacctgtacatggcctatgctgatatcatggcaaagagctgccacctggaggagggaggg gagaacggtgaagctgaagaggaggttgaggtctcctttgaggagaaagagatggagaag cagaggctcttgtaccagcaagcacggctgcacacccggggggcggccgagatggtgctg cagatgatcagtgcctgcaaaggagagacaggtgccatggtgtcctccaccctgaagctg ggcatctccatcctcaatggaggcaatgctgaggtccagcagaaaatgctggattatctt aaggacaagaaggaagttggcttcttccagagtatccaggcactgatgcaaacatgcagc gtcctggatctcaatgcctttgagagacagaacaaggccgaggggctgggcatggtgaat gaggatggcactgtcatcaatcgccagaacggagagaaggtcatggcggatgatgaattc acacaagacctgttccgattcctacaattgctctgtgaggggcacaataatgatttccag aactacctacggacacagacagggaacacgaccactattaacatcatcatttgcactgtg gactacctcctgcggctgcaggaatccatcagcgacttctactggtactactcgggcaag gatgtcattgaagagcagggcaagaggaacttctccaaagccatgtcggtggctaagcag gtgttcaacagcctcactgagtacatccagggtccctgcaccgggaaccagcagagcctg gcgcacagtcgcctatgggacgcagtggtgggattcctgcacgtgttcgcccacatgatg atgaagctcgctcaggactcaagccagatcgagctgctgaaggagctgctggatctgcag aaggacatggtggtgatgttgctgtcgctactagaagggaacgtggtgaacggcatgatc gcccggcagatggtggacatgctcgtggaatcctcatccaatgtggagatgatcctcaag ttcttcgacatgttcctgaaactcaaggacattgtgggctctgaagccttccaggactac gtaacggatccccgtggcctcatctccaagaaggacttccagaaggccatggacagccag aagcagttcagcggtccagaaatccagttcctgctttcgtgctccgaagcggatgagaac gaaatgatcaactgcgaagagttcgccaaccgcttccaggagccagcacgcgacatcggc ttcaacgtggcggtgctgctgaccaacctgtcggagcatgtgccgcatgaccctcgcctg cacaacttcctggagctggccgagagcatccttgagtacttccgcccctacctgggccgc atcgagatcatgggcgcctcacgccgcatcgagcgcatctacttcgagatctcagagacc aaccgcgcccagtgggagatgccccaggtgaaggagtccaagcgccagttcatcttcgac gtggtgaacgagggcggcgaggctgagaagatggagctcttcgtgagtttctgcgaggac accatcttcgagatgcagatcgccgcgcagatctcggagcccgagggcgagccggagacc gacgaggacgagggcgcgggcgcggcggaggcgggcgcggaaggcgcggaggagggcgcg gcggggctcgagggcacggcggccacggcggcggcgggggcgacggcgcgggtggtggcg gccgcaggccgggccctgcgaggcctcagctaccgcagcctgcggcggcgcgtgcggcgg ctgcggcggcttacggcccgcgaggcggccaccgcagtggcggcgctgctctgggcagca gtgacgcgcgctggggccgctgccgcgggggcggcggcgggcgcgctgggcctgctctgg ggctcgctgttcggcggcggcctggtggagggcgccaagaaggtgacggtgaccgagctc ctggcaggcatgcccgaccccaccagcgacgaggtgcacggcgagcagccggccgggccg ggcggagacgcagacggcgagggtgccagcgagggcgctggagacgccgcggagggcgct ggagacgaggaggaggcggtgcacgaggccgggccgggcggcgccgacggggcggtggcc gtgaccgatgggggccccttccggcccgaaggggctggcggtctcggggacatgggggac acgacgcctgcggaaccgcccacacccgagggctctcccatcctcaagaggaaattgggg gtggatggagtggaggaggagctcccgccagagccagagcccgaaccagagctggagccg gagaaagccgatgccgagaatggggagaaggaagaagttcccgagcccccaccagagccc cccaagaagcaagcacctccctcaccccctccaaagaaggaggaagctggaggcgaattc tggggagaactggaggtacagagggtgaagttcctgaactacctgtcccggaacttttac accctgcggttccttgccctcttcttggcatttgccatcaacttcatcttgctgttttat aaggtctcagactctccaccaggggaggacgacatggaaggctcagctgctggggatgtg tcaggtgcaggctctggtggcggctctggctggggcttgggggccggagaggaggcagag ggcgatgaggatgagaacatggtgtactacttcctggaggaaagcacaggctacatggaa cccgccctgcggtgtctgagcctcctgcatacactggtggcctttctctgcatcattggc tataattgtctcaaggtgcccctggtaatctttaagcgggagaaggagctggcccggaag ctggagtttgacggcctgtacatcacggagcagcctgaggacgatgacgtgaaggggcag tgggaccgactggtgctcaacacgccgtctttccctagcaactactgggacaagtttgtc aagcgcaaggtcctggacaaacatggggacatctacgggcgggagcggattgctgagcta ctgggcatggacctggccacactagagatcaccgcccacaatgagcgcaagcccaacccg ccgccagggctgctgacctggctcatgtccatcgatgtcaagtaccagatctggaagttc ggggtcatcttcacagacaactccttcctgtacctgggctggtatatggtgatgtccctc ttgggacactacaacaacttcttctttgctgcccatctcctggacatcgccatgggggtc aagacgctgcgcaccatcctgtcctctgtcacccacaatgggaaacagctggtgatgacc gtgggccttctggcggtggtcgtctacctatacaccgtggtggccttcaacttcttccgc aagttctacaacaagagcgaggatgaggatgaacctgacatgaagtgtgatgacatgatg acgtgttacctgtttcacatgtacgtgggtgtccgggctggcggaggcattggggacgag atcgaggaccccgcgggtgacgaatacgagctctacagggtggtcttcgacatcaccttc ttcttcttcgtcatcgtcatcctgttggccatcatccagggtctgatcatcgacgctttt ggtgagctccgagaccaacaagagcaagtgaaggaggatatggagaccaagtgcttcatc tgtggaatcggcagtgactactttgatacgacaccgcatggctttgagactcacacgctg gaggagcacaacctggccaattacatgtttttcctgatgtatttgataaacaaggatgag acagaacacacgggtcaggagtcttatgtctggaagatgtaccaagagagatgttgggat ttcttcccagctggtgattgtttccgtaagcagtatgaggaccagcttagctga

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