| Entry |
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| Symbol |
ITCH
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| Name |
(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X2
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| KO |
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| Organism |
ptr Pan troglodytes (chimpanzee)
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| Pathway |
| ptr04932 | Non-alcoholic fatty liver disease |
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| Brite |
KEGG Orthology (KO) [BR:ptr00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
458191 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
458191 (ITCH)
04668 TNF signaling pathway
458191 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
458191 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
458191 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:ptr04131]
458191 (ITCH)
04121 Ubiquitin system [BR:ptr04121]
458191 (ITCH)
Enzymes [BR:ptr01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
458191 (ITCH)
Membrane trafficking [BR:ptr04131]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
458191 (ITCH)
Ubiquitin system [BR:ptr04121]
Ubiquitin ligases (E3)
HECT type E3
458191 (ITCH)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
21:40601180..40749297
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| AA seq |
862 aa
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS
DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE |
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| NT seq |
2589 nt +upstreamnt +downstreamnt
atgtctgacagtggatcacaacttggttcaatgggtagcctcaccatgaaatcacagctt
cagatcactgtcatctcagcaaaacttaaggaaaataagaagaattggtttggaccaagt
ccttacgtagaggtcacagtagatggacagtcaaagaagacagaaaaatgcaacaacaca
aacagtcccaagtggaagcaaccccttacagttatcgttacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttgtgactttg
cagcttggaggtgacaaagagccaacagagacaataggagacttgtcaatttgtcttgat
gggctacagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaagtgct
tctcagaatgatgatggctccagatccaaggatgaaacaagagtgagcacaaatggatca
gatgaccctgaagatgcaggagctggtgaaaataggagagtcagtgggaataattctcca
tcactctcaaatggtggttttaaaccttctagacctccaagaccttcacgaccaccacca
cccaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagtgat
gggtctagtacaggctctctgccaccgacaaatacaaatacaaatacatctgaaggagca
acatctggattaataattcctcttactatatctggaggctcaggccctaggccattaaat
cctgtaactcaagctcccttgccacctggttgggagcagagagtggaccagcacgggcga
gtttactatgtagatcatgttgagaaaagaacaacatgggatagaccagaacctctacct
cctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcaca
agaacaacaacgtggcagaggccaacactggaatccgtccggaactatgaacaatggcag
ctacagcgtagtcagcttcaaggagcaatgcagcagtttaaccagagattcatttatggg
aatcaagatttatttgctacatcacaaagtaaagaatttgatcctcttggtccattgcca
cctggatgggagaagagaacagacagcaatggcagagtatatttcgtcaaccacaacaca
cgaattacacaatgggaagaccccagaagtcaaggtcaattaaatgaaaagcccttacct
gaaggttgggaaatgagattcacagtggatggaattccatattttgtggaccacaataga
agaactaccacctatatagatccccgcacaggaaaatctgccctagacaatggacctcag
atagcctatgttcgggacttcaaagcaaaggttcagtatttccggttctggtgtcagcaa
ctggccatgccacagcacataaagattacagtgacaagaaaaacattgtttgaggattcc
tttcaacagataatgagcttcagtccccaagatctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtca
catgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgttttatt
ggcagatttattgccatggctctgttccatgggaaattcatagacacgggtttttcttta
ccattctataagcgtatcttgaacaaaccagttggactcaaggatttagaatctattgat
ccagaattttacaattctctcatctgggttaaggaaaacaatattgaggaatgtgatttg
gaaatgtacttctccgttgacaaagaaattctaggtgaaattaagagtcatgatctgaaa
cctaatggtggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatggta
gctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttctttgaaggcttt
aatgaaattcttccccagcaatatttgcaatactttgatgcaaaggaattagaggtcctt
ttatgtggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcat
tatgcgaggaccagcaaacaaatcatgtggttttggcagtttgttaaagaaattgataat
gagaagagaatgagacttctgcagtttgttactggaacctgccgattgccagtaggagga
tttgctgatctcatggggagcaatggaccacagaaattctgcattgaaaaagttggaaaa
gaaaattggctacccagaagtcatacctgttttaatcgcctggacctgccaccatacaag
agctatgagcaactgaaggaaaagctgttgtttgccatagaagaaacagaaggatttgga
caagagtaa |
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