Pan troglodytes (chimpanzee): 459985 Help Entry 459985            CDS       T01005                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism ptr  Pan troglodytes (chimpanzee) Pathway ptr04022   cGMP-PKG signaling pathway ptr04068   FoxO signaling pathway ptr04081   Hormone signaling ptr04140   Autophagy - animal ptr04150   mTOR signaling pathway ptr04151   PI3K-Akt signaling pathway ptr04152   AMPK signaling pathway ptr04211   Longevity regulating pathway ptr04213   Longevity regulating pathway - multiple species ptr04722   Neurotrophin signaling pathway ptr04910   Insulin signaling pathway ptr04920   Adipocytokine signaling pathway ptr04923   Regulation of lipolysis in adipocytes ptr04930   Type II diabetes mellitus ptr04931   Insulin resistance ptr04932   Non-alcoholic fatty liver disease ptr04935   Growth hormone synthesis, secretion and action ptr04960   Aldosterone-regulated sodium reabsorption ptr05010   Alzheimer disease ptr05206   MicroRNAs in cancer ptr05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:ptr00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     459985 (IRS1)    04022 cGMP-PKG signaling pathway     459985 (IRS1)    04151 PI3K-Akt signaling pathway     459985 (IRS1)    04152 AMPK signaling pathway     459985 (IRS1)    04150 mTOR signaling pathway     459985 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     459985 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     459985 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     459985 (IRS1)    04935 Growth hormone synthesis, secretion and action     459985 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     459985 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     459985 (IRS1)   09149 Aging    04211 Longevity regulating pathway     459985 (IRS1)    04213 Longevity regulating pathway - multiple species     459985 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     459985 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     459985 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     459985 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     459985 (IRS1)    04932 Non-alcoholic fatty liver disease     459985 (IRS1)    04931 Insulin resistance     459985 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  459985 NCBI-ProteinID:  XP_003309544 Ensembl:  ENSPTRG00000012989 VGNC:  1981 UniProt:  H2QJJ4 A0A6D2WIP8 LinkDB All DBs Position 13:complement(128973164..129041631) Genome browser AA seq 1241 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTINHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESS GGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPE EGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQPLLHPPEPKSPGEYVNIEFG SDQPGYLSGPVASHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGVEM GRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIAAE EVSLPRATMVAASSSSAVSASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPNRN QSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGATVGGGGGSSSSSSEDVKRH SSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQP PPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ NT seq 3726 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac cacgacggagctgcggccctcggggcgggaggtggtgggggcagctgcagcggcagctcc ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc aaagaggtctggcaagtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctttgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggaaaacttc ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg agtgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc agcgtccccctgcgccggcaccatctcaacaatcccccgcccagccaggtggggctgacc cgccgatcgcgcactgagagcatcaccgccacctccccggccagcatggtgggcgggaag ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccggcttcc cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagtagcaccagtggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggtggtaaggggccctccaccctgaccgcccccaac ggtcactacattttgtctcggggtggcaatggccaccgctgcaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgaaagagaactcactcggcaggcacatcccctaccattaaccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtacacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcgtcggggggggcaccaccgc ccagacagctccaccctccacacggatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagcggccgaaagggcagtggagactatatgcccatgagccccaagagcgta tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggcggctgctctcctgacattggaggtggccccagc agcagcagcagcagcaatgccgtcccttccgggaccagctatggaaagctgtggacaaac ggggtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagcagc ggtggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggactcc aacaccagcagcccctccgactgctactacggccctgaggacccccagcacaagccagtc ctctcctactactcattgccaagatcctttaagcacacccagcgccccggggagccggag gagggtgcccggcatcagcacctccgcctttccactagctctggtcgccttctctatgct gcaacagcggatgattcttcctcttccaccagcagcgacagcctgggtgggggatactgc ggggctaggctggagcccagccttccacatccccaccatcaggttctgcagccccatctg cctcgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgaggctg tccctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcagcag cccttgctgcaccctccagagcccaagagcccgggggaatatgtcaatattgaatttggg agtgatcagcctggctacttgtctggcccggtggcttcccacagctcaccttctgtcagg tgtccatcccagctccagccagctcccagagaggaagagactggcactgaggagtacatg aagatggacctggggccgggccggagggcagcttggcaggagagcactggggtcgagatg ggcagactgggccctgcacctcccggggctgctagcatttgcaggcctacccgggcagtg cccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagctacgtg gacacctcgccagctgcccctgtaagctatgctgacatgcggacaggcattgctgcagag gaggtgagcctgcccagggccaccatggttgctgcctcctcatcctcagcagtctctgct tccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctggggggc ccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaaccgcaac cagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagctccgag actttctcctcaacacccagtgccacccgggtgggcaacacagtgccctttggagcgggg gcaacagtagggggcggtggcggtagcagcagcagcagcagcgaggatgtgaaacgccac agctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagcccccaag gagccagcccaactgtgtggggctgctgggggtttggagaatggtcttaactacatagac ctggatttggtcaaggacttcaaacagtgccctcaggagtgcacccctgaaccgcagcct cccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacccgccgc tcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggaccgt cagtag

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