Pan troglodytes (chimpanzee): 469446
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Entry
469446 CDS
T01005
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr00140
Steroid hormone biosynthesis
ptr01100
Metabolic pathways
ptr04913
Ovarian steroidogenesis
ptr04925
Aldosterone synthesis and secretion
ptr04927
Cortisol synthesis and secretion
ptr04934
Cushing syndrome
Module
ptr_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ptr_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ptr_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ptr_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
469446
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
469446
04925 Aldosterone synthesis and secretion
469446
04927 Cortisol synthesis and secretion
469446
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
469446
Enzymes [BR:
ptr01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
469446
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
469446
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GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
KR
NmrA
Ldh_1_N
Sacchrp_dh_NADP
Ilm1
Semialdhyde_dh
Motif
Other DBs
NCBI-GeneID:
469446
NCBI-ProteinID:
XP_009426484
Ensembl:
ENSPTRG00000024031
LinkDB
All DBs
Position
1:116699822..116707408
Genome browser
AA seq
375 aa
AA seq
DB search
MAMTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFRPELREEFSKLQNKTKLTV
LEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVP
VFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGG
TLYTCALRPMYIYGEGSRFLSASVNEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALR
ALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSLPLSLMYWIGFLL
EIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVG
SLVDRHKETLKSKTQ
NT seq
1128 nt
NT seq
+upstream
nt +downstream
nt
atggccatgacgggctggagctgccttgtgacaggagcaggagggtttctgggacagagg
atcatccgcctcttggtgaaggagaaggagctgaaggagatcagggtcttggacaaggcc
ttcagaccagaattgagagaggaattttctaaactccagaacaagaccaagctgacagtg
ctggaaggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtc
atcatccacaccgcctgtatcattgatgtcttcggtgtcactcacagggagtctatcatg
aatgtcaatgtgaaaggtacccagctcctgttagaggcctgtgtccaagctagtgtgcca
gtcttcatctacaccagtagcatagaggtagccgggcccaactcctacaaggaaatcatc
cagaatggccacgaagaagagcctctggaaaacacatggcccgctccatacccacatagc
aaaaagcttgctgagaaggctgtgctggcggctaacgggtggaatctgaaaaacggcggc
accctgtacacttgtgccttacgacccatgtatatctatggggaaggaagccgattcctt
tctgctagtgtaaacgaggccctgaacaacaatgggatcctgtcaagtgttggaaagttc
tccactgttaacccagtctatgttggcaatgtggcctgggcccacattctggccttgagg
gccctgcaggaccccaagaaggccccaagcatccgaggacagttctactatatctcagat
gacacgcctcaccaaagctatgataaccttaattacaccctgagcaaagagttcggcctc
cgccttgattccagatggagccttcctttatccctgatgtattggattggcttcctgctg
gaaatagtgagcttcctactcaggccaatttacacctatcgacctcccttcaaccgccac
atagtcacattgtcaaatagcgtattcaccttctcttataagaaggctcagcgagatctg
gcatataagccactctacagctgggaggaagccaagcagaaaacggtggagtgggttggt
tcccttgtggaccggcacaaggagaccctgaagtccaagactcagtga
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