KEGG   Panthera uncia (snow leopard): 125938415
Entry
125938415         CDS       T08832                                 
Name
(RefSeq) steroid 21-hydroxylase isoform X1
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
puc  Panthera uncia (snow leopard)
Pathway
puc00140  Steroid hormone biosynthesis
puc01100  Metabolic pathways
puc04925  Aldosterone synthesis and secretion
puc04927  Cortisol synthesis and secretion
puc04934  Cushing syndrome
Module
puc_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:puc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    125938415
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    125938415
   04927 Cortisol synthesis and secretion
    125938415
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    125938415
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:puc00199]
    125938415
Enzymes [BR:puc01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     125938415
Cytochrome P450 [BR:puc00199]
 Cytochrome P450, animal type
  CYP21 family
   125938415
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 125938415
NCBI-ProteinID: XP_049509489
LinkDB
Position
B2
AA seq 492 aa
MLLLGLLLLTALAGTRLLWNKWKYRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKLGPVYR
LRLGLQDVVVLNSKRTIEEAMIRRWVDFAGRPQMPSYKLVSQPYQDLSLGDYSLLWKAHK
KLTRSALLLGIRNSMEPLVEQMTQEFCERMRAQAGTPVAIQKEFSFLTCSIICCLTFGDK
EDTLVHAFHDCVQDLMKSWKHWSIQVLDIVPFLRFFPNPGLRRLKQALENRDRIVEKQLK
QHKDSMVAGQWRDMTDYMLQGMGKPRAEKGHGQLLEGHVHMSVVDLFIGGTETTATTLSW
AVAFLLHHPEIQQRLQEELDCELGPGASGSRVPLKDPARLPLLTATIAEVLRLRPVVPLA
LPHRTTRHSSILGYDIPEGTVVIPNLQGAHLDDTVWEQPHEFRPDRFLVPGTRPRVLAFG
CGARVCLGEPLARLELFVVLARLLHAFTLLPPMGPLPSLRPRSHCGINLTMQPFQVRLQP
RGAVALGLSQHQ
NT seq 1479 nt   +upstreamnt  +downstreamnt
atgctactccttgggctgctactgctgaccgcactggccggcacccgcctgctgtggaac
aagtggaagtacaggagcctccacctcccacctcttgcccccggcttcctacacctgctg
cagcccgaccttcccatctatctgcttggtctgactcagaaactgggccctgtctatagg
ctccgcctcgggctgcaagatgtggtggtgctgaactctaagaggaccattgaggaggcc
atgatcaggagatgggtggactttgctggcagaccccagatgccctcctataagctggta
tctcagccctaccaggacctctcactaggggactattccctgctctggaaggctcacaag
aaactcacccgctcggccctgctgctgggcatccgcaactccatggagccactggtggag
cagatgacccaggagttctgtgagcgcatgagagcccaggccggcacccctgtggccatc
cagaaggagttctctttcctcacctgcagcatcatctgttgcctcacctttggagacaag
gaggacaccttagtacatgcctttcatgactgtgtccaagatttgatgaaaagctggaag
cactggtccatccaagttttggacatagttccctttctcaggttcttccccaacccgggc
ctccggaggctgaagcaggccttggagaacagggaccgcattgtagagaagcagctgaag
cagcacaaggacagcatggtggcaggccagtggagggacatgaccgactacatgctccaa
gggatggggaagccaagagcagaaaagggccatggacagctccttgaaggacacgtgcat
atgtctgtggtggaccttttcattggtggcactgagaccacggcgaccaccctctcctgg
gctgtggcgttcttgcttcaccaccctgagattcagcaacgactgcaggaggagctggac
tgtgaactgggccctggggcttcaggctcccgagtcccgctcaaagaccctgcacggttg
cccttgctcactgccaccatcgctgaagtgctgcgcctgcggcctgttgtgcccctggcc
ctgcctcaccgcaccacgcggcatagcagcatcttaggctacgacatccctgagggcacg
gttgtcatccccaacctgcaaggcgcccacttggacgacacagtctgggagcagccacat
gagttccggccggatcgtttcctggtcccaggcaccagaccgagagtgctggcctttggc
tgcggagcgcgagtgtgcctgggcgagccgctggcacgccttgagctctttgtggtgctg
gcgcggctgctccacgccttcacgctgctgccccccatgggcccgctgccctctctgcga
cccaggtcccactgtggcatcaacctcacaatgcagcctttccaggtgcggctgcagccc
cggggagcagtggccctggggctgagccagcaccagtga

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