KEGG   PATHWAY: schg01055
Entry
schg01055                   Pathway                                
Name
Biosynthesis of vancomycin group antibiotics - Streptomyces changanensis
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
schg01055  Biosynthesis of vancomycin group antibiotics
schg01055

Drug
D00212  Vancomycin (USP)
Organism
Streptomyces changanensis [GN:schg]
Gene
NRO40_01865  [KO:K01710] [EC:4.2.1.46]
NRO40_11185  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
NRO40_12710  [KO:K16435] [EC:4.2.1.159]
NRO40_12720  [KO:K16438] [EC:5.1.3.-]
NRO40_12725  [KO:K16436] [EC:2.6.1.- 2.6.1.106]
NRO40_12730  rfbB; dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]
NRO40_12765  [KO:K16438] [EC:5.1.3.-]
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
schg00400  Phenylalanine, tyrosine and tryptophan biosynthesis
schg00520  Amino sugar and nucleotide sugar metabolism
schg00620  Pyruvate metabolism
KO pathway
ko01055   

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