KEGG   MODULE: senq_M00924
Entry
senq_M00924       Pathway   Module                                 
Name
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Definition
(K02302,(K02303,K13542) (K02304,K24866)) (K02190,K03795,K22011) K03394 (K05934,K13541,K21479) K05936 (K02189,K13541) K02188 K05895 (K02191 K03399,K00595) K06042 K02224
Diagram
senq_M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
senq_M00924

Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
senq00860  Porphyrin metabolism
senq01240  Biosynthesis of cofactors
senq01100  Metabolic pathways
Organism
Salmonella enterica subsp. enterica serovar Enteritidis EC20090531 [GN:senq]
Gene
AU40_11460  cobalt-precorrin-2 C(20)-methyltransferase [KO:K03394]
AU40_11465  sirohydrochlorin cobaltochelatase [KO:K02190]
AU40_11470  cobalt-precorrin-6A reductase [KO:K05895]
AU40_11475  cbiH; cobalt-precorrin-3B C(17)-methyltransferase [KO:K05934]
AU40_11480  cobalamin biosynthesis protein CbiG [KO:K02189]
AU40_11485  cbiF; cobalt-precorrin-4 C(11)-methyltransferase [KO:K05936]
AU40_11490  cobalt-precorrin-6Y C(15)-methyltransferase [KO:K02191]
AU40_11495  cobalt-precorrin-6Y C(5)-methyltransferase [KO:K03399]
AU40_11500  cbiD; cobalt-precorrin-5B (C(1))-methyltransferase [KO:K02188]
AU40_11505  cbiC; precorrin-8X methylmutase [KO:K06042]
AU40_11515  cobyrinic acid a,c-diamide synthase [KO:K02224]
AU40_19005  cysG; siroheme synthase [KO:K02302]
Reaction
R03194  
R03947  
R05807  
R05808  
R11580  
R05810  
R07772  
R07773  
R05812  
R07774  
R07775  
R05814  
R05815  
Compound
C01051  Uroporphyrinogen III
C02463  Precorrin 2
C05778  Sirohydrochlorin
C11538  Cobalt-sirohydrochlorin
C17401  Cobalt-factor III
C11540  Cobalt-precorrin 4
C16242  Cobalt-precorrin 5A
C16243  Cobalt-precorrin 5B
C11542  Cobalt-precorrin 6
C11543  Cobalt-dihydro-precorrin 6
C16244  Cobalt-precorrin 7
C11545  Cobalt-precorrin 8
C05773  Cobyrinate
C06504  Cob(II)yrinate a,c diamide
Reference
PMID:22616870
  Authors
Moore SJ, Warren MJ
  Title
The anaerobic biosynthesis of vitamin B12.
  Journal
Biochem Soc Trans 40:581-6 (2012)
DOI:10.1042/BST20120066
Reference
PMID:16042604
  Authors
Frank S, Brindley AA, Deery E, Heathcote P, Lawrence AD, Leech HK, Pickersgill RW, Warren MJ
  Title
Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway.
  Journal
Biochem Soc Trans 33:811-4 (2005)
DOI:10.1042/BST0330811
Reference
PMID:32241908
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194
KO module
M00924
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