KEGG   Saprolegnia parasitica: SPRG_06761
Entry
SPRG_06761        CDS       T04137                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase 2
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
spar  Saprolegnia parasitica
Pathway
spar00240  Pyrimidine metabolism
spar00670  One carbon pool by folate
spar00790  Folate biosynthesis
spar01100  Metabolic pathways
spar01232  Nucleotide metabolism
spar01240  Biosynthesis of cofactors
Module
spar_M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Brite
KEGG Orthology (KO) [BR:spar00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    SPRG_06761
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    SPRG_06761
   00670 One carbon pool by folate
    SPRG_06761
Enzymes [BR:spar01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     SPRG_06761
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     SPRG_06761
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 24129089
NCBI-ProteinID: XP_012201157
UniProt: A0A067CMI2
LinkDB
Position
Unknown
AA seq 466 aa
MVELSMIVAVARATNGIGIKGQLPWRLAGDLKRFRELTTSTADATKQNAVVMGRKTWESL
PLKHRPLPGRVNVVLSRNPAVRAALSAQTGVLAAGNLDEALGALTGVEHVFIIGGQSLYE
EAAQHPRCTRAYLTLVDGEYECDAFFPKSLASCGFAETSVSPVQIEKDISFQYIQLDRKH
EELQYLELIQKILDEGVHKGDRTGTGTISLFGAQMRFSLRHDVFPLLTTKRVFWKGVAEE
LLWFISGDTNAKTLQDKGIKIWDGNGSREFLDKLGLTHREAGDLGPVYGFQWRHFGAKYV
DMYTDYTGQGVDQLADVIHKIKHSPNDRRILLSAWNPSDLGLMALPPCHMFCQFYVANGE
LSCQMYQRSADMGLGVPFNIASYALLTRMIAQVCGLKAGDFIHVIGDAHVYSNHVEPLQE
QLKRTPSPFPMLKINPAKMDIDKFTFDDFTIEGYTPQKTIKMEMAI
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggtggagctaagcatgatcgttgctgtcgcgcgggccacaaacggcatcggcatcaag
ggccagctgccgtggcgcctcgcgggcgacctcaagcgctttcgtgagcttacgacgtcg
acggccgacgcaaccaagcagaacgccgtcgtgatgggccgcaaaacttgggagtcgctg
ccacttaagcaccgccccctgcctgggcgcgtcaacgtcgtgctctcgcgcaaccccgca
gtccgcgcagcgctctcagcgcagacaggagttcttgccgccgggaaccttgacgaagct
ctcggcgctctcactggcgtcgagcatgttttcatcatcggcggccagagtttgtatgaa
gaagccgcacagcacccgcgctgcacacgtgcgtacctcacgctagttgatggcgagtac
gagtgcgatgcgttcttccccaagtcgcttgcatcgtgcggctttgctgaaacgtcggtg
tcgccggttcaaattgagaaggacatttcgtttcagtacatccagctagaccgcaagcac
gaggagctgcagtatctcgagctcattcaaaagattctcgacgaaggtgtgcacaagggc
gaccgcacaggcacgggcacgatctcgctctttggcgcacagatgcgcttcagtttgcgc
cacgacgtatttcccttactgacaacgaaacgcgtcttctggaaaggtgtcgctgaggag
ctgctttggttcatcagcggcgacacgaatgccaagaccctgcaggacaagggcatcaag
atttgggacggcaacggctcgcgcgagttccttgacaagctcggtctcacacaccgcgaa
gctggtgatcttgggcctgtctacggctttcagtggcgccactttggtgccaagtacgtc
gacatgtacaccgactacacgggtcaaggtgtcgatcagctcgcggacgtcatccacaag
atcaagcactcaccgaacgaccgccggattctcctctcggcgtggaacccatcggacctg
gggctcatggcactgccgccgtgtcacatgttttgccagttttacgtcgcaaacggtgag
ctttcatgccagatgtaccagcgatcggctgacatgggtctcggcgtaccctttaatatt
gcgagctacgcactcttgacgcgcatgattgcgcaggtgtgcggcttgaaagctggtgac
tttatccacgtgattggcgacgcacacgtgtactctaaccacgtcgagccgctccaagag
caattgaagcggacgccctctccgttcccgatgctcaagattaacccagccaagatggac
atcgacaagttcactttcgatgattttacgattgaaggctacacaccccagaagacgatc
aagatggagatggccatctag

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