KEGG   Sus scrofa (pig): 654406
Entry
654406            CDS       T01009                                 
Symbol
AKR1CL1
Name
(RefSeq) aldo-keto reductase family 1, member C-like 1
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc00140  Steroid hormone biosynthesis
ssc00590  Arachidonic acid metabolism
ssc00790  Folate biosynthesis
ssc01100  Metabolic pathways
ssc04913  Ovarian steroidogenesis
ssc05208  Chemical carcinogenesis - reactive oxygen species
Module
ssc_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ssc_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    654406 (AKR1CL1)
   00590 Arachidonic acid metabolism
    654406 (AKR1CL1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    654406 (AKR1CL1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    654406 (AKR1CL1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    654406 (AKR1CL1)
Enzymes [BR:ssc01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     654406 (AKR1CL1)
    1.1.1.188  prostaglandin-F synthase
     654406 (AKR1CL1)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     654406 (AKR1CL1)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     654406 (AKR1CL1)
SSDB
Motif
Pfam: Aldo_ket_red T4_Cef
Other DBs
NCBI-GeneID: 654406
NCBI-ProteinID: NP_001033715
Ensembl: ENSSSCG00000025277
UniProt: Q2TJA5
LinkDB
Position
10:65559508..65572892
AA seq 322 aa
MALSRCVKLNDGHLMPVLGLGTLVSEGVPKSKAGEATRVAIEVGYRHIDAAYVYENEEEV
GSALREKIADGTVKREELFYTTKLWATFFRPELVRPALERSLKKLRLDYVDLFIIHVPIT
MKPGEELLPKDASGKVIFDTVDLRDTWAALEKCKDAGLTKSIGVSNFNHKQLEMILNKPG
LKYKPVCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRNSKWVEESNPYLLEDPVL
NAIAKKHNRSPAQVALRYQLQRGVVVLAKSFNEQRIKENFQVFBFELPPEDMKTIDGLNQ
NLRYFKLLFAVDHPYYPYSEEY
NT seq 969 nt   +upstreamnt  +downstreamnt
atggcactcagccgttgcgtgaagctgaatgaygggcacctcatgcccgttcttggactt
ggcactctcgtctctgaaggggtccctaagagcaaggctggcgaggccaccagagtggct
atcgaggtaggttaccgtcacattgatgcagcctacgtctatgaaaacgaggaggaggtg
ggcagygccctgcgggagaagatcgcggatggcacggtgaagagggaggagctgttctac
accaccaagctttgggctactttctttcgacctgaattggttcgaccagccctggaaaga
tcactgaagaaacttcggctggattatgttgatctcttcattattcacgtgccaatcacg
atgaagcctggggaggagcttctgcctaaggatgccagtgggaaagttatttttgatacr
gtggacctgcgtgacacatgggcggctctggagaagtgtaaagatgcaggcttgaccaaa
tccatcggggtgtccaatttcaatcacaagcagctggagatgatcctgaacaagccaggg
ctcaagtacaagcccgtctgcaaccaggtggaatgccacccttacctcaatcagagcaaa
cttctggagttttgcaagtccaaggacatcgttctagttgcctatagtgcactgggatcc
caaagaaactcaaagtgggtggaagagagcaacccatatctcttagaggatccagtctta
aatgctattgccaagaaacacaayagaagcccagcgcaggttgccctgcgctaccagctg
cagcggggagtggtggtcctggccaagagcttcaatgagcagaggatcaaagagaacttc
caggtttttractttgaattgcctccagaagatatgaaaacaatcgatggcctcaaccaa
aatttaagatattttaagttactctttgctgtcgatcacccttactacccctattctgaa
gagtactga

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