KEGG   Toxoplasma gondii: TGME49_249180
Entry
TGME49_249180     CDS       T01093                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
tgo  Toxoplasma gondii
Pathway
tgo00240  Pyrimidine metabolism
tgo00670  One carbon pool by folate
tgo00790  Folate biosynthesis
tgo01100  Metabolic pathways
tgo01232  Nucleotide metabolism
tgo01240  Biosynthesis of cofactors
Module
tgo_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:tgo00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    TGME49_249180
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    TGME49_249180
   00670 One carbon pool by folate
    TGME49_249180
Enzymes [BR:tgo01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     TGME49_249180
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     TGME49_249180
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 7899539
NCBI-ProteinID: XP_002367252
UniProt: A0A125YXY3
LinkDB
Position
XII:complement(join(4362462..4362545,4363083..4363393,4364028..4364120,4364521..4364662,4365067..4365139,4365519..4365612,4366108..4366357,4366769..4367100,4367566..4367702,4368196..4368512))
AA seq 610 aa
MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
NT seq 1833 nt   +upstreamnt  +downstreamnt
atgcagaaaccggtgtgtctggtcgtcgcgatgacccccaagaggggcatcggcatcaac
aacggcctcccgtggccccacttgaccacagatttcaaacacttttctcgtgtgacaaaa
acgacgcccgaagaagccagtcgcctgaacgggtggcttcccaggaaatttgcaaagacg
ggcgactctggacttccctctccatcagtcggcaagagattcaacgccgttgtcatggga
cggaaaacctgggaaagcatgcctcgaaagtttagacccctcgtggacagattgaacatc
gtcgtttcctcttccctcaaagaagaagacattgcggcggagaagcctcaagctgaaggc
cagcagcgcgtccgagtctgtgcttcactcccagcagctctcagccttctggaggaagag
tacaaggattctgtcgaccagatttttgtcgtgggaggagcgggattgtacgaggcagcg
ctgtctctgggcgttgcctctcacctgtacatcacgcgtgtagcccgcgagtttccgtgc
gacgttttcttccctgcgttccccggagatgacattctttcaaacaaatcaactgctgcg
caggctgcagctcctgccgagtctgtgttcgttcccttttgtccggagctcggaagagag
aaggacaatgaagcgacgtatcgacccatcttcatttccaagaccttctcagacaacggg
gtaccctacgactttgtggttctcgagaagagaaggaagactgacgacgcagccactgcg
gaaccgagcaacgcaatgagctccttgacgtccacgagggagacaactcccgtgcacggg
ttgcaggctccttcttcggccgcagccattgccccggtgttggcgtggatggacgaagaa
gaccggaaaaaacgcgagcaaaaggaactgattcgggccgttccgcatgttcactttaga
ggccatgaagaattccagtaccttgatctcattgccgacattattaacaatggaaggaca
atggatgaccgaacgggcgttggtgtcatctccaaattcggctgcactatgcgctactcg
ctggatcaggcctttccacttctcaccacaaagcgtgtgttctggaaaggggtcctcgag
gagttgctgtggttcattcgcggcgacacgaacgcaaaccatctttctgagaagggcgtg
aagatctgggacaagaatgtgacacgcgagttcctcgattcgcgcaatctcccccaccga
gaggtcggagacatcggcccgggctacggcttccagtggagacacttcggcgcggcatac
aaagacatgcacacagactacacaggtcagggcgtcgaccagctgaagaatgtgatccag
atgctgagaacgaatccaacagatcgtcgcatgctcatgactgcctggaatcctgcagcg
ctggacgaaatggcgctgccgccttgtcacttgttgtgccagttctacgtgaacgaccag
aaggagctgtcctgcatcatgtatcagcggtcgtgcgatgtcggcctcggcgtccccttc
aacatcgcttcctattcgcttttgacgctcatggttgcacacgtctgcaacctaaaacct
aaggagttcattcacttcatggggaacacgcatgtctacacgaaccatgtcgaggcttta
aaagagcagctgcggagagaaccgagaccgttccccattgtgaacatcctcaacaaggaa
cgcatcaaggaaatcgacgatttcaccgccgaggattttgaggtcgtgggctacgtcccg
cacggacgaatccagatggagatggctgtctag

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