KEGG   Trichechus manatus latirostris (Florida manatee): 101347132
Entry
101347132         CDS       T05135                                 
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
  KO
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu00350  Tyrosine metabolism
tmu00790  Folate biosynthesis
tmu01100  Metabolic pathways
tmu04728  Dopaminergic synapse
tmu04917  Prolactin signaling pathway
tmu05012  Parkinson disease
tmu05030  Cocaine addiction
tmu05031  Amphetamine addiction
tmu05034  Alcoholism
Module
tmu_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    101347132
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    101347132
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    101347132
  09156 Nervous system
   04728 Dopaminergic synapse
    101347132
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    101347132
  09165 Substance dependence
   05030 Cocaine addiction
    101347132
   05031 Amphetamine addiction
    101347132
   05034 Alcoholism
    101347132
Enzymes [BR:tmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     101347132
SSDB
Motif
Pfam: Biopterin_H TH_ACT TOH_N LTP_2
Other DBs
NCBI-GeneID: 101347132
NCBI-ProteinID: XP_004389447
UniProt: A0A2Y9E9I9
LinkDB
Position
Unknown
AA seq 496 aa
MPTPNTAAPQAKGFRRAVSELDAKQAEAIMVRGESPRFIGRRQSLIEDARKEREAAAAAS
LEPGDPLEAIAFQEKDGQAVLNLLFSLRGTKSAPLSRVMKVFETFEAKIHHLETRPAARP
RSGGPHLEYFVRCEVPSADRATLLSSVRRVSEDLRGAKEDKVPWFPRKVSELDQCHHLVT
KFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYQHGEPIPRVEYTAEEIATWKEVYTTLKG
LYATHACREHLEAFELLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLA
SLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDE
EIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSDEPEVRAFDPEAAAVQP
YQDQTYQSVYFVSESFSDAKDKLRSYAARIQRPFSVRFDPYTLAIEVLDSPRSIRRSLEA
VQDDLQALGHALSVIG
NT seq 1491 nt   +upstreamnt  +downstreamnt
atgcccacccccaacacggccgcaccgcaggccaaaggcttccgccgggccgtgtccgag
ctggacgccaagcaggccgaggccatcatggtaagaggtgagtctccccggttcatcggg
cggcggcagagcctcattgaggacgcacgcaaggaacgggaggcggcggcggcggcctct
ttggagcccggggaccccctggaggccatagccttccaggagaaggatggccaggctgtg
ctgaacctgctcttctccctgcgcggcaccaagtccgcgcccctgtcacgtgtcatgaag
gtgtttgagacttttgaagccaaaatccaccacctggagacacggccagccgctaggcct
aggagcgggggcccccacctggagtacttcgtccgctgcgaggtgcccagcgccgaccgg
gccaccctgctcagctccgtgcgccgggtgtccgaggacctgcgaggtgccaaggaggac
aaggtcccctggttcccgaggaaagtctccgaactggaccagtgccaccacctggtcacc
aagtttgacccagacctggacttggaccacccgggcttctcggaccaggcatacaggcag
cgcaggaagctaatcgcggagatagccttccagtaccagcatggtgagccgattccccgc
gtggagtacacagccgaggagattgccacctggaaggaggtctacacgaccctgaagggg
ctctatgccacccacgcctgccgtgagcacctggaggccttcgagttactggagcgcttc
agtggctaccgggaagacaacatcccccagctggaggatgtgtcccgcttcctgaaggag
cggacgggattccagctgcggcccgtggctggcctgctgtccgcccgcgacttcctggcc
agcctggccttccgtgtgttccagtgtacccagtacatccgccacgcgtcctcgcccatg
cactcccccgagccggactgctgccatgagctgctgggccacgtgcccatgctggccgac
aggacattcgcacagttctcccaggacatcggcctggcatccctgggggcgtcggatgag
gaaattgagaagctatccacgctatactggttcacggtggagttcggtctgtgtaagcaa
aatggcgaggtgaaggcctacggcgccgggctgctctcctcctacggggagctcctgcac
tccctgtctgacgagcctgaggtccgggcctttgacccagaagcggcggccgtgcagccc
taccaggaccagacctaccagtccgtctactttgtgtctgagagcttcagtgacgccaag
gacaagctgaggagctatgctgcacgcatccagcgcccgttctccgtgaggtttgaccca
tacacgctggccatcgaggtgctggacagcccccgctccatccggcgctcactggaggcc
gtccaggatgacctgcaggccctcggccacgcactgagcgtcatcggctag

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