KEGG   PATHWAY: tvd03070
Entry
tvd03070                    Pathway                                
Name
Bacterial secretion system - Thalassomonas viridans
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
tvd03070  Bacterial secretion system
tvd03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Thalassomonas viridans [GN:tvd]
Gene
SG34_000020  yidC; membrane protein insertase YidC [KO:K03217]
SG34_000515  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
SG34_000545  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
SG34_000550  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
SG34_000555  tatC; twin-arginine translocase subunit TatC [KO:K03118]
SG34_001380  gspC; type II secretion system protein GspC [KO:K02452]
SG34_001385  gspD; type II secretion system secretin GspD [KO:K02453]
SG34_001390  gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]
SG34_001395  gspF; type II secretion system inner membrane protein GspF [KO:K02455]
SG34_001400  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
SG34_001405  gspH; type II secretion system minor pseudopilin GspH [KO:K02457]
SG34_001410  gspI; type II secretion system minor pseudopilin GspI [KO:K02458]
SG34_001415  gspJ; type II secretion system minor pseudopilin GspJ [KO:K02459]
SG34_001420  gspK; type II secretion system minor pseudopilin GspK [KO:K02460]
SG34_001425  gspL; type II secretion system protein GspL [KO:K02461]
SG34_001430  [KO:K02462]
SG34_001785  secE; preprotein translocase subunit SecE [KO:K03073]
SG34_002015  secY; preprotein translocase subunit SecY [KO:K03076]
SG34_003090  secD; protein translocase subunit SecD [KO:K03072]
SG34_003095  secF; protein translocase subunit SecF [KO:K03074]
SG34_003670  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
SG34_005715  yajC; preprotein translocase subunit YajC [KO:K03210]
SG34_005720  secD; protein translocase subunit SecD [KO:K03072]
SG34_005725  secF; protein translocase subunit SecF [KO:K03074]
SG34_006165  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
SG34_007585  [KO:K11903]
SG34_013370  tssH; type VI secretion system ATPase TssH [KO:K11907]
SG34_013390  [KO:K11903]
SG34_013415  tssI; type VI secretion system tip protein VgrG [KO:K11904]
SG34_015005  [KO:K11891]
SG34_015010  [KO:K11892]
SG34_015040  [KO:K11903]
SG34_015220  sctL; type III secretion system stator protein SctL [KO:K03223]
SG34_015230  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
SG34_015245  [KO:K03221]
SG34_015260  sctC; type III secretion system outer membrane ring subunit SctC [KO:K03219]
SG34_015280  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
SG34_015290  [KO:K04059]
SG34_015300  sctW; type III secretion system gatekeeper subunit SctW [KO:K04058]
SG34_015310  sctN; type III secretion system ATPase SctN [KO:K03224] [EC:7.4.2.8]
SG34_015365  sctQ; type III secretion system cytoplasmic ring protein SctQ [KO:K03225]
SG34_015370  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
SG34_015375  sctS; type III secretion system export apparatus subunit SctS [KO:K03227]
SG34_015380  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
SG34_015385  sctU; type III secretion system export apparatus subunit SctU [KO:K03229]
SG34_015645  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
SG34_015650  [KO:K11892]
SG34_015660  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
SG34_015665  tagH; type VI secretion system-associated FHA domain protein TagH [KO:K11913]
SG34_017725  secG; preprotein translocase subunit SecG [KO:K03075]
SG34_017975  tssI; type VI secretion system tip protein VgrG [KO:K11904]
SG34_017980  [KO:K11903]
SG34_017985  tssH; type VI secretion system ATPase TssH [KO:K11907]
SG34_018030  [KO:K11915] [EC:3.1.3.16]
SG34_018040  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
SG34_018045  tssL; type VI secretion system protein TssL [KO:K11892]
SG34_018055  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
SG34_018060  tagH; type VI secretion system-associated FHA domain protein TagH [KO:K11913]
SG34_021625  [KO:K02453]
SG34_021665  [KO:K02455]
SG34_021670  [KO:K02454] [EC:7.4.2.8]
SG34_021675  gspG; type II secretion system major pseudopilin GspG [KO:K02456]
SG34_022250  [KO:K12340]
SG34_023210  tolC; outer membrane channel protein TolC [KO:K12340]
SG34_027425  secB; protein-export chaperone SecB [KO:K03071]
SG34_029165  tssI; type VI secretion system tip protein VgrG [KO:K11904]
SG34_029195  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
SG34_029200  [KO:K11892]
SG34_029210  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
SG34_029225  tssH; type VI secretion system ATPase TssH [KO:K11907]
SG34_029260  [KO:K11903]
SG34_031090  [KO:K12340]
SG34_032285  sctV; type III secretion system export apparatus subunit SctV [KO:K03230]
SG34_032350  sctN; type III secretion system ATPase SctN [KO:K03224] [EC:7.4.2.8]
SG34_032360  sctC; type III secretion system outer membrane ring subunit SctC [KO:K03219]
SG34_032380  [KO:K03223]
SG34_032490  [KO:K03225]
SG34_032495  sctR; type III secretion system export apparatus subunit SctR [KO:K03226]
SG34_032500  sctS; type III secretion system export apparatus subunit SctS [KO:K03227]
SG34_032505  sctT; type III secretion system export apparatus subunit SctT [KO:K03228]
SG34_032510  sctU; type III secretion system export apparatus subunit SctU [KO:K03229]
SG34_032555  [KO:K04056]
SG34_032560  [KO:K04059]
SG34_032735  sctW; type III secretion system gatekeeper subunit SctW [KO:K04058]
SG34_032870  sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]
SG34_032880  [KO:K03221]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   

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