KEGG   Ursus americanus (American black bear): 123802294
Entry
123802294         CDS       T07931                                 
Symbol
AKR1C8
Name
(RefSeq) putative aldo-keto reductase family 1 member C8 isoform X1
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
uar  Ursus americanus (American black bear)
Pathway
uar00140  Steroid hormone biosynthesis
uar00590  Arachidonic acid metabolism
uar00790  Folate biosynthesis
uar01100  Metabolic pathways
uar04913  Ovarian steroidogenesis
uar05208  Chemical carcinogenesis - reactive oxygen species
Module
uar_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
uar_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:uar00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    123802294 (AKR1C8)
   00590 Arachidonic acid metabolism
    123802294 (AKR1C8)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    123802294 (AKR1C8)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    123802294 (AKR1C8)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    123802294 (AKR1C8)
Enzymes [BR:uar01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     123802294 (AKR1C8)
    1.1.1.188  prostaglandin-F synthase
     123802294 (AKR1C8)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     123802294 (AKR1C8)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     123802294 (AKR1C8)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 123802294
NCBI-ProteinID: XP_045668844
UniProt: A0A452QSM1
LinkDB
Position
Unknown
AA seq 324 aa
MDLNRSRSVKLNDGHVMPVLGFGTLAPDDVPKSKSGEATKVAIDVGFRHFDAAYIYQNEK
EVGKAIREKIADGTVKREDIFYTTKLWTTFCRPELVRPALERSLKALQLDYVDLFIIHLP
IAMKPGEELMPKDANGDFILETVDLCSTWAAMEKCKDAGLTKSIGVSNFNHKQLEMILNK
PGLKYKPVCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQKNPGWVERDSPSLLEEP
VLNAIAKKHNRSPGQVALRFQLQRGVVVLVKSFNQKRIKENFEVFNFELTPEDMKAIEGL
NRNFRYFKLPFAVGHPHYPFSEEY
NT seq 975 nt   +upstreamnt  +downstreamnt
atggacctcaaccggagtcgttcggtgaaactgaatgatgggcacgtcatgccagtgctc
gggtttggcactcttgctcctgatgatgttcctaagagcaagtctggtgaggccaccaaa
gtggctattgatgtaggtttccgtcacttcgatgcagcatacatctatcaaaatgagaag
gaagttggcaaggccattcgagagaagatcgctgacggcaccgtgaagagagaggacata
ttctacaccaccaagctttggactactttctgtcgcccggaattggttcgaccagccctg
gaaagatcgctgaaggcacttcaactggactacgtggatctcttcattatccatttgcca
atcgccatgaagcctggggaggagcttatgcccaaggatgccaatggggactttatttta
gagacggtggacctgtgtagcacgtgggcggccatggagaagtgtaaagatgcaggttta
accaagtccattggggtgtcaaatttcaaccacaagcagctggaaatgatcctgaacaaa
ccagggctcaagtacaagcccgtgtgcaaccaggtggagtgtcatccgtacctcaaccag
agcaaactcctggagttctgcaagtccaaggacatcgttcttgttgcctacagtgccctg
ggatcccaaaagaacccaggctgggtggaaagggatagcccatctctcttggaagagcca
gtcttgaacgccattgccaagaaacacaatagaagcccaggccaggtggccctgcgcttc
cagctgcagcgaggggtggtggtcctagtcaagagcttcaaccagaagagaatcaaagag
aactttgaggtttttaactttgaattgactccagaagacatgaaagcaattgaaggcctc
aacaggaatttccgatatttcaaactaccgtttgctgtcggtcatcctcattacccattt
tctgaagaatactga

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