KEGG   PATHWAY: vcm03060
Entry
vcm03060                    Pathway                                
Name
Protein export - Vibrio cholerae O1 M66-2
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
vcm03060  Protein export
vcm03060

Other DBs
GO: 0043952 0043953
Organism
Vibrio cholerae O1 M66-2 [GN:vcm]
Gene
VCM66_0004  yidC; putative Inner membrane protein [KO:K03217]
VCM66_0086  tatA-1; tatA protein [KO:K03116]
VCM66_0087  [KO:K03117]
VCM66_0088  [KO:K03118]
VCM66_0147  ftsY; cell division protein FtsY [KO:K03110]
VCM66_0306  secE; preprotein translocase, SecE subunit [KO:K03073]
VCM66_0518  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
VCM66_0598  secG; preprotein translocase, SecG subunit [KO:K03075]
VCM66_0641  lspA; signal peptidase II [KO:K03101] [EC:3.4.23.36]
VCM66_0700  [KO:K03210]
VCM66_0701  secD-1; protein-export membrane protein SecD [KO:K03072]
VCM66_0702  secF-1; protein-export membrane protein SecF [KO:K03074]
VCM66_2317  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
VCM66_2385  lepB; signal peptidase I [KO:K03100] [EC:3.4.21.89]
VCM66_2496  secY; preprotein translocase, SecY subunit [KO:K03076]
VCM66_2573  secB; protein-transport protein SecB [KO:K03071]
VCM66_A0492  tatA-2; tatA protein [KO:K03116]
VCM66_A0650  secF-2; protein-export membrane protein SecF [KO:K03074]
VCM66_A0651  secD-2; protein-export membrane protein SecD [KO:K03072]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   

DBGET integrated database retrieval system