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Name |
Description |
Object |
Legend |
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map00910
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Nitrogen metabolism |
... fixation [MD:M00175] is the process of reducing atmospheric molecular nitrogen to ammonia, a biolog... |
C00058 (Formate) C00488 (Formamide) C00014 (Ammonia) C00192 (Hydroxylamine) C06058 (Nitroalkane) C00... |
Formate Formamide 3.5.1.49 Ammonia Hydroxylamine Nitroalkane 1.7.2.6 1.9.6.1 1.7.99.- 1.7.7.2 1.13.1... |
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map01524
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Platinum drug resistance |
...s and intrinsic or acquired resistance to the treatment. Platinum resistance could arise from decrea... |
...NN)) D01363 (Carboplatin (JP18/USP/INN)) K04728 (ATM) K04451 (TP53) K02161 (BCL2) K04399 (CASP9) K02... |
Mitochondrion p53 signaling pathway ATM p53 Bcl-2 CASP9 CASP3 Bad IAP/XIAP Apaf-1 CytC Bid CASP8 FAD... |
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map04110
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Cell cycle |
...In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in tur... |
...6637 (BUB1B) K04802 (PCNA) K06631 (PLK1) K04728 (ATM), K06640 (ATR) K06629 (DBF4) K02537 (MAD2), K13... |
...MCM ORC APC/C APC/C SCF SCF CDK1 BubR1 PCNA Plk1 ATM/ATR Dbf4 Mad2 Bub1 Bub3 Cdc14b 14-3-3 14-3-3σ C... |
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map05032
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Morphine addiction |
...Although morphine is highly effective for the treatment of pain, it is also known to be intensely ad... |
C00575 (3',5'-Cyclic AMP) C00575 (3',5'-Cyclic AMP) C00334 (4-Aminobutanoate) C00334 (4-Aminobutanoa... |
...gnaling Gi/o Withdrawal from chronic morphine treatment MOR cAMP GABA 5'-AMP Adenosine PDE Disinhibi... |
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map01521
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EGFR tyrosine kinase inhibitor resistance |
... mechanisms that drive resistance to EGFR TKI treatment. Most outstanding mechanisms are: the second... |
C00165 (Diacylglycerol) C05981 (Phosphatidylinositol-3,4,5-trisphosphate) D07907 (Erlotinib (INN)) D... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
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map01522
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Endocrine resistance |
Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast canc... |
C00951 (Estradiol-17beta) C00951 (Estradiol-17beta) C00575 (3',5'-Cyclic AMP) C00951 (Estradiol-17be... |
ENDOCRINE RESISTANCE GPR30 Src MMP HB-EGF EGFR HB-EGF CoA DNA DNA cAMP PKA Ras Raf MEK ERK1/2 GPR30... |
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map01523
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Antifolate resistance |
...ntifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chron... |
D00142 (Methotrexate (JP18/USP/INN)), D05589 (Pralatrexate (JAN/USAN/INN)), D04766 (Lometrexol sodiu... |
ANTIFOLATE RESISTANCE RFC ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 GARTF Antifolate Methotrexate (MTX) Pemetre... |
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map05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
...81B), K17027 (MIR181C), K17028 (MIR181D) K04728 (ATM) K17009 (MIR155) K04694 (SOCS1) K17033 (MIR335)... |
...S HMGA2 miR-30e ITGB3 UBC9 miR-200 Let-7 miR-181 ATM miR-155 SOCS1 miR-335 SOX4 TNC miR-126 miR-206 ... |
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map00330
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Arginine and proline metabolism |
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...5 (gbh), K27001 (GDAH), 3.5.3.7, R01990 K00613 (GATM), 2.1.4.1, R01989 K01426 (E3.5.1.4), 3.5.1.4, R... |
1.5.1.11 Octopine OoxAB ARGININE AND PROLINE METABOLISM Polyamine Pathway ADC pathway ADH pathway... |
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map01100
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Metabolic pathways |
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...55 (gbuA), K25365 (gbh), K27001 (GDAH), K00613 (GATM), 2.1.4.1, 3.5.3.7, R01989, R01990 K08660 (CNDP... |
Monoterpenoid biosynthesis One carbon pool by folate Flavonoid biosynthesis Starch and sucrose metab... |
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map00403
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Indole diterpene alkaloid biosynthesis |
Indole diterpene alkaloids are a group of meroterpenoids consisting of a partial diterpene structure... |
...393 (LTMQ), R10366 K18389 (PAXQ), R10362 K18391 (ATMD), R10365 K18389 (PAXQ), R10359 K18390 (PAXD), ... |
...palinine Aflatrem Terpendole E Terpendole I LtmP AtmQ Paspaline B PaxP LtmP PaxP PaxP TerQ AtmQ AtmD... |
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map02010
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ABC transporters |
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are ... |
...23536 (nupC) K23537 (nupA) K23535 (nupB) K24821 (atm1) |
...F YphE YphD Sugar BmpA NupC NupA NupB Nucleoside Atm1 |
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map03440
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Homologous recombination |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs... |
...2 (BRIP1) K10683 (BARD1) K10728 (TOPBP1) K04728 (ATM) K12173 (BRE) K20776 (BABAM) K11864 (BRCC3) |
...RCA1 CtIP PALB2 RAP80 Abraxas BRIP1 BARD1 TOPBP1 ATM BRE NBA1 BRCC36 5' to 3' resection Recognition |
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map04064
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NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...05856 (LCK) K07371 (BLNK) K03173 (TRAF2) K04728 (ATM) K07210 (IKBKG) K24070 (PARP1) K16065 (PIAS4) K... |
...yn Btk Lck BLNK TRAF2 Genotoxic agent DNA damage ATM NEMO PARP1 PIASy Ubs9 SUMOylation NEMO Shuttlin... |
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map04068
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FoxO signaling pathway |
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellu... |
...781 (katE) K04564 (SOD2) K04402 (GADD45) K04728 (ATM) K15618 (BCL6) K05072 (IL7R) K17845 (KLF2) K042... |
...dd45 FasL Bim TRAIL Bcl-6 Catalase Mn-SOD Gadd45 ATM Bcl-6 IL-7R KLF2 EDG1/6 RAG-1/2 Cell cycle regu... |
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map04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
...2216 (CHEK1) K06640 (ATR) K06641 (CHEK2) K04728 (ATM) K10128 (RPRM) K06644 (SFN) K02206 (CDK2) K0662... |
Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS... |
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map04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
... peroxide) K04570 (BCL2L1) K02310 (DFFA) K04728 (ATM) K04451 (TP53) K01173 (ENDOG) K04727 (AIFM1) K0... |
...naling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/XIAP CAD CASP9 CASP7 C... |
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map04214
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Apoptosis - fly |
Apoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organi... |
... (TRAF6) K04404 (MAP3K7IP2) K06640 (ATR) K04728 (ATM) K04448 (JUN) K09031 (FOSLN) K16679 (WGN) K0873... |
...ragmentation RHG family Parp dTRAF2 dTAB2 Mei-41 ATM d-Jun d-Fos Wengen CytC dredd E74A bantam SKL |
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map04218
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Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
...6 (LIN54), K10752 (RBBP4) K11411 (SIRT1) K04728 (ATM) K06641 (CHEK2) K10865 (MRE11) K10866 (RAD50) K... |
... p53 ROS MKK3/6 CDK2 CycA B-MYB FOXM1 MuvB SIRT1 ATM CHK2 MRE11 RAD50 NBS1 GADD45 ATR CDC25A CHK1 RA... |
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map05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...67 (CAPN1), K03853 (CAPN2) K04451 (TP53) K04728 (ATM) K02161 (BCL2) K04570 (BCL2L1) K04361 (EGFR) K0... |
...1,4,5)P MDM2 AKT FKHR GSK3 P70S6K CAPN4 CAPN P53 ATM DNA damage Bcl-2 Bcl-XL DNA Apoptosis EGFR Ear... |