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Name |
Description |
Object |
Legend |
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map04140
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Autophagy - animal |
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, orga... |
...(PRKAA) K07359 (CAMKK2) K04427 (MAP3K7) K08852 (ERN1) K04440 (JNK) K04345 (PKA) K21247 (TP53INP2) K0... |
PI3P AUTOPHAGY - ANIMAL Nutrient starvation (Amino acids, glucose) mTORC1 complex ER stress ROS Lo... |
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map04141
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Protein processing in endoplasmic reticulum |
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of... |
...21 (BAK) K09054 (ATF6A), K09049 (ATF6B) K08852 (ERN1) K08860 (EIF2AK3) K08653 (MBTPS1) K07765 (MBTPS... |
PROTEIN PROCESSING IN ENDOPLASMIC RETICULUM Protein export Apoptosis Proteasome ATF4 CHOP JNK TR... |
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map04210
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Apoptosis |
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by a... |
...F6) K04722 (TNFRSF10A_B) K03173 (TRAF2) K08852 (ERN1) K04741 (CASP12) K02374 (PTPN13) K04724 (CFLAR)... |
Mitochondrion p53 signaling pathway TNF signaling pathway Bcl-XL ICAD ATM p53 ENDO-G AIF Bcl-2 IAP/X... |
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map04932
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Non-alcoholic fatty liver disease |
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to mor... |
...3156 (TNF) K10030 (IL8) K04389 (TNFSF6) K08852 (ERN1) K03173 (TRAF2) K04440 (JNK) K04379 (FOS), K044... |
NON-ALCOHOLIC FATTY LIVER DISEASE Simple steatosis (without inflammation and fibrosis) (Cirrhos... |
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map05010
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Alzheimer disease |
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... |
...71 (ERK) K13240 (NOS1) K08860 (EIF2AK3) K08852 (ERN1) K09054 (ATF6A) K04524 (APOE) K02183 (CALM) K04... |
PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 sAPP... |
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map05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
...45 (PKA) K04528 (SNCA) K08860 (EIF2AK3) K08852 (ERN1) K09054 (ATF6A) K03237 (EIF2S1) K04374 (ATF4) K... |
LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae... |
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map05014
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Amyotrophic lateral sclerosis |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... |
...0F6), K02125 (ATPeF08) K08860 (EIF2AK3) K08852 (ERN1) K09054 (ATF6A) K03237 (EIF2S1) K04374 (ATF4) K... |
SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell... |
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map05016
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Huntington disease |
Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... |
...3) K04684 (SP1) K04533 (HD) K04533 (HD) K08852 (ERN1) K03173 (TRAF2) K04426 (MAP3K5) K04440 (JNK) K0... |
HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN... |
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map05017
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Spinocerebellar ataxia |
The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... |
... (ATXN3) K23932 (SPTBN2) K11863 (ATXN3) K08852 (ERN1) K03173 (TRAF2) K04426 (MAP3K5) K04440 (JNK) K0... |
Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk... |
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map05022
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Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
... (MCU) K04426 (MAP3K5) K08860 (EIF2AK3) K08852 (ERN1) K09054 (ATF6A) K03237 (EIF2S1) K04374 (ATF4) K... |
PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP... |
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map05417
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Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...(TLR6) K04426 (MAP3K5) K08860 (EIF2AK3) K08852 (ERN1) K09054 (ATF6A) K03237 (EIF2S1) K04374 (ATF4) K... |
PIP AKT PDK1 PI3K p53 signaling pathway LIPID AND ATHEROSCLEROSIS GSK3β p53 Apoptosis Apoptosis Fa... |