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map05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
... (VEGFA) K02091 (CDK6) K16980 (MIRLET7) K07827 (KRAS) K02091 (CDK6) K16978 (MIR126) K04438 (CRK) K16... |
... MDM2/4 miR-221 ATM MDM2 FGFR3 PDGFRA PLCG RAF1 KRAS PKC MAP2K MAPK1 SOS1/2 GRB2 SHC1 PLCG PDGFA SHC... |
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map04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...9 (MAP2K2) K04366 (RAF1) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS), K07831 (MRAS), K07829 (RRAS), ... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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map05205
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Proteoglycans in cancer |
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that... |
...550 (ESR1) K06256 (CD44) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS), K07829 (RRAS), K07830 (RRAS2),... |
CD44v3 Tiam1 HER2 RhoA ROCK Ankyrin Cytoskeleton activation PI3K AKT CD44 Lipid Raft IP3R CAMKII Fil... |
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map05207
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Chemical carcinogenesis - receptor activation |
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stage... |
...551 (ESR2) K04361 (EGFR) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K04366 (RAF1) K04368 (MAP2K1), ... |
CHEMICAL CARCINOGENESIS - RECEPTOR ACTIVATION EGFR DNA Ras Raf MEK ERK1/2 DNA PKA pCREB MAPK sig... |
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map05224
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Breast cancer |
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breas... |
... (NCOA1), K11256 (NCOA3) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K08845 (ARAF), K04365 (BRAF), K... |
BREAST CANCER EGFR CoR Ras Raf MEK ERK1/2 Shc Grb2 SOS Estrogen signaling pathway Jagged Notch mTOR... |
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map04213
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Longevity regulating pathway - multiple species |
Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss... |
...45 (IRS3), K17446 (IRS4) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K09408 (FOXO3) K04688 (RPS6KB) ... |
FOXO S6K mTOR Akt P13K PIP LONGEVITY REGULATING PATHWAY - MULTIPLE SPECIES DNA IGF-I IGF-IR IRS1... |
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map04625
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C-type lectin receptor signaling pathway |
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of ... |
...366 (RAF1) K04409 (PAK1) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS), K07831 (MRAS), K07829 (RRAS), ... |
C-TYPE LECTIN RECEPTOR SIGNALING PATHWAY Dectin-1 Dectin-2 Mincle MCL FcRγ DC-SIGN LSP-1 KSR1 CN... |
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map04915
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Estrogen signaling pathway |
Estrogens are steroid hormones that regulate a plethora of physiological processes in mammals, inclu... |
...04684 (SP1) K04345 (PKA) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K04366 (RAF1) K04368 (MAP2K1), ... |
ESTROGEN SIGNALING PATHWAY GPER c-Src MMP HB-EGF EGFR HB-EGF DNA DNA cAMP PKA Ras Raf MEK ERK1/2 p... |
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map05034
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Alcoholism |
Alcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is pro... |
...AS) K15014 (SLC29A1_2_3) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K08845 (ARAF), K04365 (BRAF), K... |
ALCOHOLISM Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synaps... |
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map05166
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Human T-cell leukemia virus 1 infection |
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult... |
...51 (CCND2) K00787 (FDPS) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K05862 (VDAC1), K05863 (SLC25A4... |
HUMAN T-CELL LEUKEMIA VIRUS 1 INFECTION Human T-lymphotropic virus-I gp21 gp46 NRP1 CD4+ T cell... |
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map05210
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Colorectal cancer |
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. C... |
...501 (SMAD4) K08734 (MLH1) K08735 (MSH2) K07827 (KRAS) K04365 (BRAF), K04366 (RAF1), K08845 (ARAF) K0... |
DCC CASP3 TGFβ PI3K CASP9 APPL CASP3 APC Smad2 TGFβRI Smad4 hMLH1 hMSH2 K-Ras Raf JNK Axin Axin RalG... |
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map05213
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Endometrial cancer |
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common mali... |
...(CTNNB1) K02105 (CTNNB1) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K02085 (APC) K02157 (AXIN1), K0... |
β-Catenin β-Catenin Ras APC Axin GSK-3β α-Catenin β-Catenin Cell cycle Fkhrl1 BAD Casp9 ILK ErbB sig... |
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map05214
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Glioma |
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... |
...4364 (GRB2) K03099 (SOS) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K04365 (BRAF), K04366 (RAF1), K... |
EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos Ra... |
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map05216
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Thyroid cancer |
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine ca... |
K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K08530 (NR1C3) K04365 (BRAF) K04365 (BRAF) K04371 (ERK) ... |
Ras PPARγ BRAF BRAF ERK MEK PPFP RXR β-catenin c-Myc ECAD THYROID CANCER ERK CyclinD1 MEK BRAF Ras ... |
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map05221
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Acute myeloid leukemia |
Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clo... |
...osphate) K08527 (RARA), K10055 (ZBTB16) K07827 (KRAS) K07828 (NRAS) K05092 (FLT3) K09438 (SPI1) K090... |
PLZF-RARα K-Ras N-Ras FLT3 PU.1 C/EBPα AML1-ETO Jak-STAT signaling pathway mTOR signaling pathway He... |
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map05223
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Non-small cell lung cancer |
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-... |
...89 (E2F2), K06620 (E2F3) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K01116 (PLCG1), K05859 (PLCG2) ... |
PKC Retinoic acid DAG PIP Forkhead CASP9 BAD PKB/Akt PDK1 PI3K CDK4/6 CyclinD1 E2F Ras PLCγ TGFα EGF... |
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map05225
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Hepatocellular carcinoma |
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... |
...lglycerol) K04361 (EGFR) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K08845 (ARAF), K04365 (BRAF), K... |
HEPATOCELLULAR CARCINOMA EGFR Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K IGF-II IGF1R PI3K-Akt signal... |
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map05226
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Gastric cancer |
Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological cl... |
...93 (9-cis-Retinoic acid) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K08845 (ARAF), K04365 (BRAF), K... |
GASTRIC CANCER Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K PI3K-Akt signaling pathway Ras Raf MEK ERK1... |
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map05235
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PD-L1 expression and PD-1 checkpoint pathway in cancer |
Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... |
...R1_2_3) K04350 (RASGRP1) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K04379 (FOS), K04448 (JUN) K173... |
PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3ζ CD3γ C... |
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map01521
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EGFR tyrosine kinase inhibitor resistance |
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also ser... |
...66 (RAF1), K08845 (ARAF) K02833 (HRAS), K07827 (KRAS), K07828 (NRAS) K01110 (PTEN) K08052 (NF1) K050... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |