| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
map05321
|
|
Inflammatory bowel disease |
Inflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is ... |
...443 (IL10) K10165 (NOD2) K10159 (TLR2), K10160 (TLR4), K10168 (TLR5) K05435 (IL13) K05429 (IL2) K050... |
...en processing and presentation RORα FOXP3 FOXP3 TLR4 Cytokine-cytokine receptor interaction T cell r... |
|
map05417
|
|
Lipid and atherosclerosis |
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-r... |
...734 (NFKBIA) K05400 (LY96) K05399 (LBP) K10160 (TLR4) K04391 (CD14) K04733 (IRAK4) K04430 (MAP2K4), ... |
...8 IRAK1 TIRAP JNK TRAF6 TAB1 TAB2 IκBα MD-2 LBP TLR4 CD14 IRAK4 +p +p +p +p +p +p MKK4/7 NF-κB... |
|
map04064
|
|
NF-kappa B signaling pathway |
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that fu... |
...12) K05147 (TNFRSF11A) K05473 (TNFSF11) K10160 (TLR4) K04403 (MAP3K7IP1), K04404 (MAP3K7IP2), K12793... |
...RAF6 IκBα A20 TRAF1/2 IL8 BLC SDF-1α RANK RANKL TLR4 T cell receptor signaling pathway B cell recept... |
|
map04066
|
|
HIF-1 signaling pathway |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... |
... (NPPA) K16451 (TIMP1) K03159 (TNFRSF3) K10160 (TLR4) K04735 (RELA), K02580 (NFKB1) K04687 (IFNG) K0... |
...nd barrier functions Inflammation Mitochondrion TLR4 NF-κB DNA LPS IFN-γ IFN-γR DNA Tranaslation Cal... |
|
map04145
|
|
Phagosome |
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mech... |
...4391 (CD14) K10159 (TLR2) K10169 (TLR6) K10160 (TLR4) K13240 (NOS1) K13885 (SCARB1) K06856 (IGH) K03... |
...idase Stx13 Stx7 CD36 MARCO Lox1 CD14 TLR2 TLR6 TLR4 H2O2 Lysosome lysosomal acid hydorolases NOS S... |
|
map04217
|
|
Necroptosis |
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumo... |
...3 (TRAF2), K09849 (TRAF5) K08849 (MLKL) K10160 (TLR4) K05130 (IFNAR1), K05131 (IFNAR2), K05132 (IFNG... |
NECROPTOSIS TNF TNFR1 TRADD TRAF2/5 MLKL TLR4 IFNR LPS IFN JAKs TRAILR TRAIL Fas FasL IAPs Casp8 cFL... |
|
map04613
|
|
Neutrophil extracellular trap formation |
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action... |
...456 (AKT) K01370 (CASP1) K20917 (GSDMD) K10160 (TLR4) K04394 (CASP4) K06544 (SELPLG) K06496 (SELP) K... |
...HIL EXTRACELLULAR TRAP FORMATION CASP1 GSDMD TLR4 CASP11 Bacteria/LPS Toll-like receptor signali... |
|
map04620
|
|
Toll-like receptor signaling pathway |
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens... |
...10169 (TLR6) K05399 (LBP) K10161 (TLR9) K10160 (TLR4) K05409 (TIRP) K05402 (TOLLIP) K05842 (TRIF) K0... |
...D80 TLR2 MD-2 TLR5 TLR3 TLR2 TLR1 TLR6 LBP TLR9 TLR4 TRAM TOLLIP TRIF TIRAP CD14 IKKγ IRAK4 CASP8 TO... |
|
map04621
|
|
NOD-like receptor signaling pathway |
Specific families of pattern recognition receptors are responsible for detecting various pathogens a... |
...1 (STAT2) K04394 (CASP4) K20917 (GSDMD) K10160 (TLR4) K04729 (MYD88) K05130 (IFNAR1), K05131 (IFNAR2... |
...ria Toxins JAK1 TYK2 STAT1/2 pro-CASP4/11 GSDMD TLR4 MyD88 Nucleus IFNAR DNA ANTXR Endosome Bacteria... |
|
map04936
|
|
Alcoholic liver disease |
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol ov... |
...05411 (IRF3) K05400 (LY96) K05399 (LBP) K10160 (TLR4) K05842 (TRIF) K04391 (CD14) K04733 (IRAK4) K02... |
...AF6 IKKε IL-6 TAB1 TAB2 IκBα TNFα IRF3 MD-2 LBP TLR4 TRIF CD14 IRAK4 ALCOHOLIC LIVER DISEASE Compl... |
|
map05130
|
|
Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
...86 (IL1R1) K04519 (IL1B) K03175 (TRAF6) K10160 (TLR4) K00134 (GAPDH) K23654 (nleE) K02985 (RP-S3e) K... |
...gnaling pathway IRAK1/4 MyD88 IL-1R IL-1β TRAF6 TLR4 GAPDH NleE DNA RPS3 NleH1 TAB TAK1 JNK p38 ERK... |
|
map05131
|
|
Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...86 (IL1R1) K04519 (IL1B) K03175 (TRAF6) K10160 (TLR4) K04403 (MAP3K7IP1), K04404 (MAP3K7IP2), K12793... |
...κBα IKKα/β TRAF2/5 RIP1 TRADD IL-1R IL-1β TRAF6 TLR4 DNA TAB TAK1 p38 ERK1/2 p50 TLR5 TNFα IL-8 IKK... |
|
map05132
|
|
Salmonella infection |
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid ... |
...5400 (LY96) K10168 (TLR5) K10169 (TLR6) K10160 (TLR4) K04391 (CD14) K13286 (sipC) K17092 (ANXA2) K17... |
...MLC Myosin II Invasion SopE TLR2 MD-2 TLR5 TLR6 TLR4 CD14 SipC ANXA2 p11 SipA TNFR1 TRAIL-R AvrA Sse... |
|
map05133
|
|
Pertussis |
Pertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bact... |
...2944 (cyaA) K02183 (CALM) K15126 (bteA) K10160 (TLR4) K05400 (LY96) K12973 (pagP) K02580 (NFKB1), K0... |
...teA Type III secretion system TCT Peptidoglycan TLR4 LPS LOS MD2 PagP NF-κB Myd88 TIRAP IRF3 DNA NOD... |
|
map05134
|
|
Legionellosis |
Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophi... |
...2406 (fliC) K10168 (TLR5) K10159 (TLR2) K10160 (TLR4) K04391 (CD14) K04729 (MYD88) K03156 (TNF) K045... |
...ent and coagulation cascades FlaA TLR5 LPS TLR2 TLR4 CD14 MyD88 TNFα IL-1β IL-6 IL-8 IL-12 MIP-2/KC ... |
|
map05135
|
|
Yersinia infection |
Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... |
...448 (JUN) K04729 (MYD88) K04730 (IRAK1) K10160 (TLR4) K04733 (IRAK4) K04371 (ERK) K04368 (MAP2K1), K... |
...p +p +p MKK4/7 NF-κB MKK3/6 AP-1 MyD88 IRAK1 TLR4 IRAK4 ERK +p MEK1/2 +p YopP/J IL-8 TNFα IFNβ ... |
|
map05142
|
|
Chagas disease |
Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease, also called Ame... |
...itol-3,4,5-trisphosphate) K10159 (TLR2) K10160 (TLR4) K04687 (IFNG) K23590 (CRP) K08057 (CALR) K0399... |
TLR2 TLR4 IFNγ gp160 TcCRT C3b C1q Complement pathway Toll-like receptor signaling pathway TLR9 ... |
|
map05145
|
|
Toxoplasmosis |
Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite ... |
...142 (TLR11) K14141 (PFNL) K05400 (LY96) K10160 (TLR4) K03283 (HSPA1_6_8) K10159 (TLR2) K04687 (IFNG)... |
...PS TgCDPK1 PLA2 Laminin MIC3 SAG TLR11 PFTG MD2 TLR4 TgHSP70 TLR2 IFNγ IFNGR CCR5 C18 CD154 CD40 STA... |
|
map05152
|
|
Tuberculosis |
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the... |
...91 (CD14) K04729 (MYD88) K04733 (IRAK4) K10160 (TLR4) K05398 (TLR1), K10169 (TLR6) K02187 (CASP3) K0... |
...γ CIITA ERK1/2 NF-κB TRAF6 LPS CD14 Myd88 IRAK4 TLR4 TLR1/6 Apoptosis CASP3 TNFα TNF-R1 TRADD FADD A... |
|
map05161
|
|
Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...AP3K7IP2) K04734 (NFKBIA) K10159 (TLR2) K10160 (TLR4) K05403 (TIRAP) K04733 (IRAK4) K02580 (NFKB1), ... |
...TAK1 IRAK1 TIRAP MyD88 TRAF6 TAB1 TAB2 IκB TLR2 TLR4 TIRAP IRAK4 MyD88-dependent pathway +p +p +p... |