KEGG Modules

Carbohydrate metabolism
Central carbohydrate metabolism
M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sdy00010 sdy01200 sdy01100]
M00002 Glycolysis, core module involving three-carbon compounds [PATH:sdy00010 sdy01200 sdy01230 sdy01100]
M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sdy00010 sdy00020 sdy01100]
M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sdy00010 sdy00020 sdy00620 sdy00785 sdy01200 sdy01210 sdy01100]
M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:sdy00020 sdy01200 sdy01100]
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:sdy00020 sdy01200 sdy01210 sdy01230 sdy01100]
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:sdy00020 sdy01200 sdy01210 sdy01100]
M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:sdy00030 sdy01200 sdy01100 sdy01120]
M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:sdy00030 sdy01200 sdy01100 sdy01120]
M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:sdy00030 sdy01200 sdy01230 sdy01100 sdy01120]
M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:sdy00030 sdy00230 sdy01200 sdy01230 sdy01100]
M00008 Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate [PATH:sdy00030 sdy01200 sdy01100 sdy01120]

Other carbohydrate metabolism
M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:sdy00052 sdy01100]
M00854 Glycogen biosynthesis, glucose-1P => glycogen/starch [PATH:sdy00500 sdy01100]
M00855 Glycogen degradation, glycogen => glucose-6P [PATH:sdy00500 sdy01100]
M00982 Methylcitrate cycle [PATH:sdy00640 sdy00020 sdy01200 sdy01100 sdy01120]

Energy metabolism
Carbon fixation
M00168 CAM (Crassulacean acid metabolism), dark [PATH:sdy00620 sdy00710 sdy01200 sdy01100 sdy01120]
M00579 Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate [PATH:sdy00430 sdy00620 sdy00720 sdy01200 sdy01100 sdy01120]

Methane metabolism
Nitrogen metabolism
M00530 Dissimilatory nitrate reduction, nitrate => ammonia [PATH:sdy00910 sdy01310 sdy01100 sdy01120]

Sulfur metabolism
M00176 Assimilatory sulfate reduction, sulfate => H2S [PATH:sdy00920 sdy01320 sdy01100 sdy01120]

Photosynthesis
ATP synthesis
M00144 NADH:quinone oxidoreductase, prokaryotes [PATH:sdy00190 sdy01100]
M00149 Succinate dehydrogenase, prokaryotes [PATH:sdy00190 sdy01100]
M00150 Fumarate reductase, prokaryotes [PATH:sdy00190 sdy01100]
M00155 Cytochrome c oxidase, prokaryotes [PATH:sdy00190 sdy01100]
M00153 Cytochrome bd ubiquinol oxidase [PATH:sdy00190]
M00157 F-type ATPase, prokaryotes and chloroplasts [PATH:sdy00190 sdy01100]

Lipid metabolism
Fatty acid metabolism
M00082 Fatty acid biosynthesis, initiation [PATH:sdy00061 sdy01212 sdy01100]
M00083 Fatty acid biosynthesis, elongation [PATH:sdy00061 sdy01212 sdy01100]
M00086 beta-Oxidation, acyl-CoA synthesis [PATH:sdy00061 sdy00071 sdy01212 sdy01100]
M00087 beta-Oxidation [PATH:sdy00071 sdy01212 sdy01100]

Sterol biosynthesis
Lipid metabolism
M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:sdy00564 sdy01100]
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE [PATH:sdy00564 sdy01100]

Nucleotide metabolism
Purine metabolism
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sdy00230 sdy01100]
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sdy00230 sdy01232 sdy01240 sdy01100]
M00050 Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sdy00230 sdy01232 sdy01100]
M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sdy00230 sdy00240 sdy01232 sdy01100]
M00959 Guanine ribonucleotide degradation, GMP => Urate [PATH:sdy00230 sdy01232 sdy01100]

Pyrimidine metabolism
M00051 De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP [PATH:sdy00240 sdy01240 sdy01100]
M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP [PATH:sdy00240 sdy01232 sdy01240 sdy01100]
M00938 Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP [PATH:sdy00240 sdy01232 sdy01100]

Amino acid metabolism
Serine and threonine metabolism
M00020 Serine biosynthesis, glycerate-3P => serine [PATH:sdy00260 sdy00680 sdy01200 sdy01230 sdy01100]
M00018 Threonine biosynthesis, aspartate => homoserine => threonine [PATH:sdy00260 sdy01230 sdy01100 sdy01110]
M00621 Glycine cleavage system [PATH:sdy00260 sdy00630 sdy00670 sdy00785 sdy01200 sdy01100]
M00033 Ectoine biosynthesis, aspartate => ectoine [PATH:sdy00260 sdy01210 sdy01230 sdy01100 sdy01120]

Cysteine and methionine metabolism
M00021 Cysteine biosynthesis, serine => cysteine [PATH:sdy00270 sdy00920 sdy01320 sdy01200 sdy01230 sdy01100 sdy01110]
M00017 Methionine biosynthesis, aspartate => homoserine => methionine [PATH:sdy00270 sdy01230 sdy01100]

Branched-chain amino acid metabolism
M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sdy00290 sdy00770 sdy01210 sdy01230 sdy01100 sdy01110]
M00570 Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sdy00290 sdy01230 sdy01100]
M00432 Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sdy00290 sdy01210 sdy01230 sdy01100 sdy01110]

Lysine metabolism
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:sdy00300 sdy01230 sdy01100]
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:sdy00300 sdy01230 sdy01100 sdy01110]

Arginine and proline metabolism
M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:sdy00220 sdy01210 sdy01230 sdy01100]
M00844 Arginine biosynthesis, ornithine => arginine [PATH:sdy00220 sdy01230 sdy01100]
M00978 Ornithine-ammonia cycle [PATH:sdy00220 sdy01100 sdy01110]
M00015 Proline biosynthesis, glutamate => proline [PATH:sdy00330 sdy01230 sdy01100]
M00970 Proline degradation, proline => glutamate [PATH:sdy00330 sdy01100]

Polyamine biosynthesis
M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:sdy00330 sdy01100]

Histidine metabolism
M00026 Histidine biosynthesis, PRPP => histidine [PATH:sdy00340 sdy01230 sdy01100 sdy01110]

Aromatic amino acid metabolism
M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:sdy00400 sdy01230 sdy01100 sdy01110]
M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:sdy00400 sdy01230 sdy01100 sdy01110]
M00024 Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:sdy00400 sdy01230 sdy01100 sdy01110]
M00025 Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:sdy00400 sdy01230 sdy01100]

Other amino acid metabolism
M00118 Glutathione biosynthesis, glutamate => glutathione [PATH:sdy00480 sdy01240 sdy01100]

Glycan metabolism
Nucleotide sugar biosynthesis
M00909 UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc [PATH:sdy00520 sdy01250 sdy01100]
M00995 UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc [PATH:sdy00520 sdy01250]
M00549 UDP-Glc biosynthesis, Glc => UDP-Glc [PATH:sdy00520 sdy01250 sdy01100]
M00999 UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA [PATH:sdy00520 sdy00053 sdy01250]
M00554 UDP-Gal biosynthesis, Gal => UDP-Gal [PATH:sdy00520 sdy00052 sdy01250 sdy01100]
M01000 GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:sdy00520 sdy01250]
M00063 CMP-3-deoxy-D-manno-octulosonate biosynthesis, ribulose-5P => CMP-KDO [PATH:sdy00541 sdy01250 sdy01100]
M01014 UDP-ManNAcA biosynthesis, UDP-GlcNAc => UDP-ManNAcA [PATH:sdy00541]
M00064 ADP-L-glycero-D-manno-heptose biosynthesis, sedoheptulose-7P => ADP-LDmanHep [PATH:sdy00541 sdy01250 sdy01100]
M00761 Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:sdy00541 sdy01100]
M00793 dTDP-L-rhamnose biosynthesis, glucose-1P => dTDP-L-Rha [PATH:sdy00521 sdy00523 sdy00541 sdy01250 sdy01100 sdy01110]

Glycan biosynthesis
Glycosaminoglycan metabolism
Lipopolysaccharide metabolism
M00060 KDO2-lipid A biosynthesis, Raetz pathway, LpxL-LpxM type [PATH:sdy00540 sdy01100]

Other polysaccharide metabolism
Metabolism of cofactors and vitamins
Cofactor and vitamin metabolism
M00127 Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP [PATH:sdy00730 sdy01240 sdy01100]
M00899 Thiamine salvage pathway, HMP/HET => TMP [PATH:sdy00730 sdy01100]
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:sdy00740 sdy01240 sdy01100 sdy01110]
M00124 Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P [PATH:sdy00750 sdy01240 sdy01100]
M00115 NAD biosynthesis, aspartate => quinolinate => NAD [PATH:sdy00760 sdy01240 sdy01100]
M00119 Pantothenate biosynthesis, valine/L-aspartate => pantothenate [PATH:sdy00770 sdy01240 sdy01100 sdy01110]
M00120 Coenzyme A biosynthesis, pantothenate => CoA [PATH:sdy00770 sdy01240 sdy01100]
M00572 Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP [PATH:sdy00780 sdy01240 sdy01100]
M00123 Biotin biosynthesis, pimeloyl-ACP/CoA => biotin [PATH:sdy00780 sdy01240 sdy01100]
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:sdy00785 sdy01240 sdy01100]
M00126 Tetrahydrofolate biosynthesis, GTP => THF [PATH:sdy00790 sdy00670 sdy01240 sdy01100]
M00880 Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:sdy00790 sdy01240 sdy01100]
M00988 PreQ1 biosynthesis, GTP => 7-Aminomethyl-7-deazaguanine [PATH:sdy00790 sdy01100]
M00846 Siroheme biosynthesis, glutamyl-tRNA => siroheme [PATH:sdy00860 sdy01240 sdy01100 sdy01110]
M00121 Heme biosynthesis, plants and bacteria, glutamate => heme [PATH:sdy00860 sdy01240 sdy01100 sdy01110]
M00926 Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme [PATH:sdy00860 sdy01240 sdy01100]
M00117 Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:sdy00130 sdy01240 sdy01100 sdy01110]
M00989 Ubiquinone biosynthesis, O2-independent, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol [PATH:sdy00130 sdy01240 sdy01100 sdy01110]
M00116 Menaquinone biosynthesis, chorismate (+ polyprenyl-PP) => menaquinol [PATH:sdy00130 sdy01240 sdy01100 sdy01110]

Biosynthesis of terpenoids and polyketides
Terpenoid backbone biosynthesis
M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway [PATH:sdy00900 sdy01100 sdy01110]
M00364 C10-C20 isoprenoid biosynthesis, bacteria [PATH:sdy00900 sdy01100 sdy01110]

Plant terpenoid biosynthesis
Macrolide biosynthesis
Enediyne biosynthesis
Type II polyketide biosynthesis
Polyketide sugar unit biosynthesis
Biosynthesis of other secondary metabolites
Biosynthesis of phytochemical compounds
Biosynthesis of beta-lactams
Biosynthesis of other antibiotics
Biosynthesis of other fungal compounds
Biosynthesis of other bacterial compounds
Xenobiotics biodegradation
Aromatics degradation

Gene set
Pathogenicity
M00363 EHEC pathogenicity signature, Shiga toxin [PATH:sdy05131]

Drug resistance
M00697 Multidrug resistance, efflux pump MdtEF-TolC

Plant pathogenicity
Symbiosis
Module set
Metabolic capacity
M00616 Sulfate-sulfur assimilation