Entry |
Name |
Description |
Category |
Pathway |
H00001
|
B-cell acute lymphoblastic leukemia
B-cell acute lymphocytic leukemia
|
Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic ...
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Cancer
|
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H00002
|
T-cell acute lymphoblastic leukemia
T-cell acute lymphocytic leukemia
|
Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic ...
|
Cancer
|
|
H00003
|
Acute myeloid leukemia
|
Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program ...
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Cancer
|
hsa05221 Acute myeloid leukemia
|
H00004
|
Chronic myeloid leukemia
|
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP) ...
|
Cancer
|
hsa05220 Chronic myeloid leukemia
|
H00005
|
Chronic lymphocytic leukemia
|
Chronic lymphocytic leukemia (CLL) is caused by the abnormal progressive accumulation of functionally incompetent monoclonal B-lymphocytes in blood, bone marrow, lymph nodes and spleen. It is the most ...
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Cancer
|
|
H00006
|
Hairy cell leukemia
|
Hairy cell Leukemia (HCL) is a chronic lymphoproliferative disorder that is defined, according to the WHO classification, as a mature (peripheral) B-cell neoplasm. HCL accounts for between 2-3% of all ...
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Cancer
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H00007
|
Hodgkin lymphoma
|
Hodgkin's lymphoma (HL) is one of the most frequent lymphomas in the Western world and often affects young adults. HL is subdivided into classical and nodular lymphocyte-predominant forms. About 95% of ...
|
Cancer
|
|
H00008
|
Burkitt lymphoma
|
Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young ...
|
Cancer
|
|
H00009
|
Adult T-cell leukemia
|
Adult T-cell leukemia (ATL) is one of the most aggressive hematologic malignancies and is caused by human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 Tax protein has been demonstrated to be the oncogenic ...
|
Cancer; Viral infectious disease
|
hsa05166 Human T-cell leukemia virus 1 infection
|
H00010
|
Multiple myeloma
|
Multiple myeloma is a disorder in which malignant plasma cells accumulate, generally derived from one clone in the bone marrow. Intricate interactions occur between the bone-marrow microenvironment and ...
|
Cancer
|
|
H00011
|
Lymphoplasmacytic lymphoma
|
Lymphoplasmacytic lymphoma (LPL)/Waldenstrom's macroglobulinemia (WM) is a non-Hodgkin lymphoma (NHL) subtype. LPL/WM is a neoplasm of small B-lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually ...
|
Cancer
|
|
H00012
|
Polycythemia vera
|
Polycythemia vera (PV) is a clonal myeloproliferative disease characterized by an erythroid dominant trilineage proliferation of hematopoietic precursor cells. PV belongs to the family of chronic myeloproliferative ...
|
Cancer
|
|
H00013
|
Small cell lung cancer
|
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of ...
|
Cancer
|
hsa05222 Small cell lung cancer
|
H00014
|
Non-small cell lung cancer
|
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous ...
|
Cancer
|
hsa05223 Non-small cell lung cancer
|
H00015
|
Malignant pleural mesothelioma
|
Malignant mesothelioma (MM) is a rare but very aggressive tumor that arises from mesothelial cells lining the pleural, peritoneal and pericardial cavities. Malignant pleural mesothelioma (MPM) is the most ...
|
Cancer
|
|
H00016
|
Oral cancer
|
Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary glands, gingiva, floor of the mouth, oropharynx, buccal surfaces and other intra-oral locations ...
|
Cancer
|
|
H00017
|
Esophageal cancer
|
Esophageal cancer represents the 9th leading cancer in the world and is associated with a 5-year survival rate under 25%. The two main forms are squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC) ...
|
Cancer
|
|
H00018
|
Gastric cancer
|
Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse ...
|
Cancer
|
hsa05226 Gastric cancer
|
H00019
|
Pancreatic cancer
|
Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). ...
|
Cancer
|
hsa05212 Pancreatic cancer
|
H00020
|
Colorectal cancer
|
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined ...
|
Cancer
|
hsa05210 Colorectal cancer
|
H00021
|
Renal cell carcinoma
|
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer ...
|
Cancer
|
hsa05211 Renal cell carcinoma
|
H00022
|
Bladder cancer
|
The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma ...
|
Cancer
|
hsa05219 Bladder cancer
|
H00023
|
Testicular cancer
|
Testicular germ cell tumor (TGCT) comprises about 98% of all testicular neoplasms and is thereby the most common malignancy among young males. Overall, three different entities of TGCT can be distinguished: ...
|
Cancer
|
|
H00024
|
Prostate cancer
|
Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key ...
|
Cancer
|
hsa05215 Prostate cancer
|
H00025
|
Penile cancer
|
Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare in developed countries but more common in South America and East Africa. Squamous cell carcinoma (SCC) ...
|
Cancer
|
|
H00026
|
Endometrial cancer
|
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial ...
|
Cancer
|
hsa05213 Endometrial cancer
|
H00027
|
Ovarian cancer
|
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. Approximately 90% of human ovarian cancer arises within the ovarian ...
|
Cancer
|
|
H00028
|
Choriocarcinoma
|
Gestational choriocarcinoma is a highly malignant epithelial tumor that can be associated with any type of gestational event, most often a complete hydatidiform mole (CM). CM occur in about one per 1000 ...
|
Cancer
|
|
H00029
|
Vulvar cancer
|
Vulvar cancer is a relatively uncommon malignancy, occurring at a rate of 2.2 per 100,000 women per year. Squamous cell carcinoma (SCC) is the most common type of vulvar cancer and is observed in 80% to ...
|
Cancer
|
|
H00030
|
Cervical cancer
|
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus ...
|
Cancer
|
|
H00031
|
Breast cancer
|
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland ...
|
Cancer
|
hsa05224 Breast cancer
|
H00032
|
Thyroid cancer
|
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells ...
|
Cancer
|
hsa05216 Thyroid cancer
|
H00033
|
Adrenal carcinoma
|
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy defined by a heterogeneous clinical presentation, dismal prognosis, and lack of effective therapeutic regimens. The incidence of ACC ranges ...
|
Cancer
|
|
H00034
|
Carcinoid
|
Carcinoid tumors are relatively uncommon neoplasms that nonetheless comprise up to 85% of neuroendocrine gastrointestinal neoplasms. They most frequently occur in the midgut and develop from neuroendocrine ...
|
Cancer
|
|
H00035
|
Ewing sarcoma
|
Ewing sarcoma is the second most common malignant bone tumor occurring in children and young adults, and accounts for 10-15% of all primary bone tumors. The annual incidence is approximately 0.6/million ...
|
Cancer
|
|
H00036
|
Osteosarcoma
|
Osteosarcoma is the most common type of primary bone cancer. Approximately 900 new cases of osteosarcoma are diagnosed each year in the United States. The presentation of this disease is bimodal, with ...
|
Cancer
|
|
H00037
|
Rhabdomyosarcoma
|
Rhabdomyosarcomas (RMSs) are soft tissue sarcomas that are one of the most common neoplasms in children and adolescents. RMSs are presumed to be associated with the skeletal muscle lineage, although those ...
|
Cancer
|
|
H00038
|
Melanoma
|
Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The ...
|
Cancer
|
hsa05218 Melanoma
|
H00039
|
Basal cell carcinoma
|
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial ...
|
Cancer
|
hsa05217 Basal cell carcinoma
|
H00040
|
Squamous cell carcinoma
|
Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and their number is still increasing world- wide. Approximately 200000 cases of ...
|
Cancer
|
|