KEGG    Network variation - Dopamine-PRL signaling
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ENTRYnt06553
NameDopamine-PRL signaling
CategoryPathway view; Endocrine system
Pathwayhsa04900 Neuroendocrine signaling pathway of hypothalamus-pituitary axis
hsa04917 Prolactin signaling pathway
Display drug-target relation   disease type
N00920    PRL→PRLR→JAK2→STAT5
    HPRL   PRLR*
    MFAB   PRLR*↗
 
N00702    GTP−GCH1⇉PTS⇉SPR→BH4
    DYT5a/HPABH4B   GCH1*
    HPABH4A     PTS*
    SRD       SPR*
N00705    BH4OH−PCBD1/2⇉QDPR→BH4
    HPABH4D   PCBD1*
    HPABH4C     QDPR*
N01530    Tyr+BH4−TH→L-Dopa−DDC→Dopamine−MAO→DOPAL
    DYT5b   TH*
    AADCD       DDC*

Disease nameDisease category
HPRLH01388HyperprolactinemiaEndocrine and metabolic disease
MFABH03129Multiple fibroadenomas of the breastReproductive system disease
DYT5a/HPABH4BH02557Dopa-responsive dystoniaNervous system disease
H00167PhenylketonuriaInherited metabolic disorder
HPABH4AH00167PhenylketonuriaInherited metabolic disorder
SRDH02597Sepiapterin reductase deficiencyInherited metabolic disorder
HPABH4DH00167PhenylketonuriaInherited metabolic disorder
HPABH4CH00167PhenylketonuriaInherited metabolic disorder
DYT5bH02557Dopa-responsive dystoniaNervous system disease
AADCDH01161Aromatic L-amino acid decarboxylase deficiencyNervous system disease