KEGG T01001: 5742

Homo sapiens (human): 5742

Entry

5742              CDS       T01001

Symbol

PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS

Name

(RefSeq) prostaglandin-endoperoxide synthase 1

K00509

prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]

Organism

hsa Homo sapiens (human)

Pathway

hsa00590

Arachidonic acid metabolism

hsa01100

Metabolic pathways

hsa04611

Platelet activation

hsa04726

Serotonergic synapse

hsa04923

Regulation of lipolysis in adipocytes

Drug target

Aceclofenac:

D01545

Acemetacin:

D01582<JP>

Acetylsalicylic acid (DG00015):

D00109<JP> D05181 D07579 D07580 D07581 D07582 D12595 D12596

Alminoprofen:

Aloxiprin:

Amfenac (DG01249):

Ampiroxicam:

Amtolmetin guacil:

Benzydamine (DG00014):

D01410 D07516 D07517

Bromfenac (DG01128):

D03163<JP/US> D07541

Bufexamac:

D01271

Carprofen:

D03410

Choline salicylate:

D00810

Dexibuprofen (DG00756):

D03715 D03718

Dexketoprofen:

D07269

Diclofenac (DG00441):

D00903<US> D00904<JP/US> D07816 D07817 D07818<US> D07819

Droxicam:

D07267

Epidihydrocholesterin:

D01527

Etofenamate:

D04102

Felbinac (DG00764):

D01675<JP> D01841

Fenbufen:

D01344

Fenoprofen (DG00754):

D00968<US> D02350

Flufenamic acid (DG00757):

D01581 D01823<JP> D03254<JP>

Flurbiprofen (DG00755):

D00330<JP/US> D01475<JP> D02290<US> D10254

Glycol salicylate:

D01557

Ibuprofen (DG00245):

D00126<JP/US> D01122<JP> D04490 D06606<JP/US> D08058 D08059 D09760 D12597 D12598

Ibuproxam:

D07268

Indobufen:

D07141

Indometacin (DG00241):

D00141<JP/US> D01565<JP> D02110<JP/US>

Ketoprofen (DG00753):

D00132<JP/US> D08102 D08103

Ketorolac (DG00751):

D00813<US> D08104

Lornoxicam:

D01866<JP>

Loxoprofen (DG01251):

D01709<JP> D08149

Magnesium salicylate:

D00827

Meclofenamic acid (DG00758):

D00169<US> D02341 D08162

Mefenamic acid:

D00151<JP/US>

Mofezolac:

D01718

Nabumetone:

D00425<JP/US>

Naproxcinod:

D09568

Naproxen (DG00455):

D00118<JP/US> D00970<US> D10017

Nepafenac:

D05143<JP/US>

Orpanoxin:

D05275

Oxaprozin:

D00463<JP/US>

Oxyphenbutazone (DG00746):

D05319 D08324

Pamicogrel:

D01090

Paracetamol:

D00217<JP/US>

Phenbutazone sodium glycerate:

D05451

Phenylbutazone (DG00745):

D00510 D08363 D08364

Piketoprofen (DG01250):

D08374 D08375

Piroxicam (DG00752):

D00127<JP/US> D05511 D05512 D05513

Pranoprofen:

D01578<JP>

Pravadoline maleate:

D05598

Proglumetacin (DG00750):

D01765<JP> D08427

Propacetamol (DG00828):

D07294 D08434

Salicylamide:

D01811

Salicylate meglumine:

D05791

Salsalate:

D00428

Sodium salicylate:

D00566<JP>

Sulindac:

D00120<US>

Tebufelone:

Tenidap (DG00761):

Tenoxicam:

Tiaprofenic acid:

Tolfenamic acid:

Tolmetin (DG00747):

D00158<US> D02355

Triflusal:

D07142

Trolamine:

D08501

Zaltoprofen:

D01547<JP>

Zidometacin:

D06364

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    5742 (PTGS1)
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5742 (PTGS1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    5742 (PTGS1)
  09156 Nervous system
   04726 Serotonergic synapse
    5742 (PTGS1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     5742 (PTGS1)

SSDB

Motif

Pfam:

An_peroxidase EGF EGF_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

9:122370533..122395703

AA seq 599 aa
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL

NT seq 1800 nt +upstreamnt +downstreamnt
atgagccggagtctcttgctctggttcttgctgttcctgctcctgctcccgccgctcccc
gtcctgctcgcggacccaggggcgcccacgccagtgaatccctgttgttactatccatgc
cagcaccagggcatctgtgtccgcttcggccttgaccgctaccagtgtgactgcacccgc
acgggctattccggccccaactgcaccatccctggcctgtggacctggctccggaattca
ctgcggcccagcccctctttcacccacttcctgctcactcacgggcgctggttctgggag
tttgtcaatgccaccttcatccgagagatgctcatgcgcctggtactcacagtgcgctcc
aaccttatccccagtccccccacctacaactcagcacatgactacatcagctgggagtct
ttctccaacgtgagctattacactcgtattctgccctctgtgcctaaagattgccccaca
cccatgggaaccaaagggaagaagcagttgccagatgcccagctcctggcccgccgcttc
ctgctcaggaggaagttcatacctgacccccaaggcaccaacctcatgtttgccttcttt
gcacaacacttcacccaccagttcttcaaaacttctggcaagatgggtcctggcttcacc
aaggccttgggccatggggtagacctcggccacatttatggagacaatctggagcgtcag
tatcaactgcggctctttaaggatgggaaactcaagtaccaggtgctggatggagaaatg
tacccgccctcggtagaagaggcgcctgtgttgatgcactacccccgaggcatcccgccc
cagagccagatggctgtgggccaggaggtgtttgggctgcttcctgggctcatgctgtat
gccacgctctggctacgtgagcacaaccgtgtgtgtgacctgctgaaggctgagcacccc
acctggggcgatgagcagcttttccagacgacccgcctcatcctcataggggagaccatc
aagattgtcatcgaggagtacgtgcagcagctgagtggctatttcctgcagctgaaattt
gacccagagctgctgttcggtgtccagttccaataccgcaaccgcattgccatggagttc
aaccatctctaccactggcaccccctcatgcctgactccttcaaggtgggctcccaggag
tacagctacgagcagttcttgttcaacacctccatgttggtggactatggggttgaggcc
ctggtggatgccttctctcgccagattgctggccggatcggtgggggcaggaacatggac
caccacatcctgcatgtggctgtggatgtcatcagggagtctcgggagatgcggctgcag
cccttcaatgagtaccgcaagaggtttggcatgaaaccctacacctccttccaggagctc
gtaggagagaaggagatggcagcagagttggaggaattgtatggagacattgatgcgttg
gagttctaccctggactgcttcttgaaaagtgccatccaaactctatctttggggagagt
atgatagagattggggctcccttttccctcaagggtctcctagggaatcccatctgttct
ccggagtactggaagccgagcacatttggcggcgaggtgggctttaacattgtcaagacg
gccacactgaagaagctggtctgcctcaacaccaagacctgtccctacgtttccttccgt
gtgccggatgccagtcaggatgatgggcctgctgtggagcgaccatccacagagctctga

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