| Entry |
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| Name |
Dasatinib laurylsulfate (USAN) |
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| Formula |
C22H26ClN7O2S. C12H26O4S
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| Exact mass |
753.3109
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| Mol weight |
754.403
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| Structure |
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| Class |
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| Remark |
| Product (DG00714): | D03658<JP> D06414<JP/US> |
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| Efficacy |
Antineoplastic, Tyrosine kinase inhibitor |
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| Target |
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| Metabolism |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EA BCR-ABL tyrosine kinase inhibitors
L01EA02 Dasatinib
D12609 Dasatinib laurylsulfate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03161 BCR-ABL inhibitor
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
DG02924 UGT substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
Unclassified
DG03306 FMO substrate
DG02950 FMO3 substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
PDGFRB
D12609 Dasatinib laurylsulfate (USAN)
KIT (CD117)
D12609 Dasatinib laurylsulfate (USAN)
EPH family
EPHA2
D12609 Dasatinib laurylsulfate (USAN)
Non-receptor tyrosine kinases
SRC family
SRC
D12609 Dasatinib laurylsulfate (USAN)
FYN
D12609 Dasatinib laurylsulfate (USAN)
LCK
D12609 Dasatinib laurylsulfate (USAN)
YES1
D12609 Dasatinib laurylsulfate (USAN)
ABL family
BCR-ABL [HSA_VAR:25v1]
D12609 Dasatinib laurylsulfate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12609
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03161 BCR-ABL inhibitor
DG00714 Dasatinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00714 Dasatinib
DG02924 UGT substrate
DG00714 Dasatinib
Unclassified
DG03306 FMO substrate
DG02950 FMO3 substrate
DG00714 Dasatinib
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 50
1 C8y C 19.1445 -15.7083
2 N5x N 19.1445 -17.1109
3 C8y C 20.4068 -17.8121
4 N5x N 21.5990 -17.1109
5 C8y C 21.5990 -15.7083
6 C8x C 20.4068 -15.0071
7 N1b N 17.9524 -15.0071
8 N1y N 22.8612 -15.0071
9 C1a C 20.4068 -19.2147
10 C1x C 24.0534 -15.7083
11 C1x C 25.2455 -15.0071
12 N1y N 25.2455 -13.6045
13 C1x C 24.0534 -12.9033
14 C1x C 22.8612 -13.6045
15 C8y C 16.7602 -15.7083
16 S2x S 15.6382 -14.8668
17 C8y C 14.5162 -15.6382
18 C8x C 14.9369 -16.9706
19 N5x N 16.2694 -16.9706
20 C5a C 13.3240 -15.0071
21 N1b N 12.1319 -15.7083
22 O5a O 13.2539 -13.5344
23 C8y C 10.8696 -15.0071
24 C8y C 10.8696 -13.5344
25 C8x C 9.6073 -12.8332
26 C8x C 8.4152 -13.6045
27 C8x C 8.4152 -15.0071
28 C8y C 9.6073 -15.7083
29 X Cl 12.0618 -12.8332
30 C1a C 9.6073 -17.0407
31 C1b C 26.5078 -12.9033
32 C1b C 27.7000 -13.6045
33 O1a O 28.8921 -12.9033
34 C1b C 42.9801 -17.3281
35 C1b C 41.7874 -18.0297
36 C1b C 40.5947 -17.3281
37 C1b C 39.3319 -18.0297
38 C1b C 38.1392 -17.3281
39 C1b C 36.9465 -18.0297
40 C1b C 35.7539 -17.3281
41 C1b C 34.5612 -18.0297
42 C1b C 33.2984 -17.3281
43 C1b C 32.1057 -18.0297
44 C1b C 30.9130 -17.3281
45 O2a O 29.7203 -18.0297
46 C1a C 44.2429 -18.0297
47 S4a S 28.3172 -18.0297
48 O1d O 26.9140 -18.0297
49 O1d O 28.3172 -16.6265
50 O1d O 28.3172 -19.4328
BOND 52
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 5 8 1
9 3 9 1
10 8 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 8 14 1
16 7 15 1
17 15 16 1
18 16 17 1
19 17 18 2
20 18 19 1
21 15 19 2
22 17 20 1
23 20 21 1
24 20 22 2
25 21 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
32 24 29 1
33 28 30 1
34 12 31 1
35 31 32 1
36 32 33 1
37 34 35 1
38 35 36 1
39 36 37 1
40 37 38 1
41 38 39 1
42 39 40 1
43 40 41 1
44 41 42 1
45 42 43 1
46 43 44 1
47 44 45 1
48 34 46 1
49 45 47 1
50 47 48 1
51 47 49 2
52 47 50 2
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