KEGG ORTHOLOGY: K04833

ORTHOLOGY: K04833

Entry

K04833                      KO

Symbol

SCN1A, NAV1.1

Name

voltage-gated sodium channel type I alpha

Pathway

map04728

Dopaminergic synapse

Disease

H00606

Early infantile epileptic encephalopathy

H00775

Hemiplegic migraine

H00783

Febrile seizures

H01815

Malignant migrating partial seizures in infancy

H01818

Dravet syndrome

H02564

Generalized epilepsy with febrile seizures plus

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K04833  SCN1A, NAV1.1; voltage-gated sodium channel type I alpha
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04833  SCN1A, NAV1.1; voltage-gated sodium channel type I alpha
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   K04833  SCN1A, NAV1.1; voltage-gated sodium channel type I alpha

Other DBs

GO:

0005248

TC:	1.A.1.10.7

Genes

HSA:	6323(SCN1A)

PTR:	459703(SCN1A)

PPS:	100988284(SCN1A)

GGO:	101150903(SCN1A)

PON:	100448260(SCN1A)

NLE:	100582833(SCN1A)

HMH:	116810714(SCN1A)

MCC:	704086(SCN1A)

MCF:	101925570(SCN1A)

MTHB:

126933043

MNI:

105483300

CSAB:

103217230(SCN1A)

CATY:

105576072(SCN1A)

PANU:

101002868

TGE:	112635978(SCN1A)

MLEU:

105547423(SCN1A)

RRO:	104663910(SCN1A)

RBB:

108540251

TFN:

117094914

PTEH:

111523510(SCN1A)

CANG:

105523247(SCN1A)

CJC:	100386406(SCN1A)

SBQ:	101035409(SCN1A)

CIMI:

108317712

CSYR:

103274239

MMUR:

105867222(SCN1A)

LCAT:

123643698

PCOQ:

105819551(SCN1A)

OGA:

100963118

MMU:	20265(Scn1a)

MCAL:

110308193

MPAH:

110319360

RNO:	81574(Scn1a)

MCOC:

116090254

ANU:

117703069

MUN:

110541015

CGE:	100752032(Scn1a)

MAUA:

101843542

PROB:

127222465(Scn1a)

PLEU:

114680593

MORG:

121433274(Scn1a)

MFOT:

126488455

AAMP:

119818474

NGI:	103732330(Scn1a)

HGL:	101710495(Scn1a)

CPOC:

100715839

CCAN:

109681943(Scn1a)

DORD:

105994257(Scn1a)

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:	101517773(SCN1A)

TUP:	102487844(SCN1A)

GVR:	103601034(SCN1A)

CFA:	478775(SCN1A)

VVP:

112916444

VLG:	121501768(SCN1A)

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

101685844(SCN1A)

MNP:

132013801

MLK:	131827140(SCN1A)

NVS:

122902553

ORO:	101376410(SCN1A)

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101081823(SCN1A)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:	102951441(SCN1A)

PPAD:

PUC:

AJU:

HHV:

BTA:	529590(SCN1A)

BIU:	109566928(SCN1A)

BBUB:

102394594(SCN1A)

BBIS:

105002370(SCN1A)

CHX:

102179054

OAS:	101123531(SCN1A)

BTAX:

128071189(SCN1A)

ODA:	120854867(SCN1A)

CCAD:

122453741(SCN1A)

MBEZ:

129538674(SCN1A)

SSC:	106506270(SCN1A)

CFR:

102511300

CBAI:

105081966(SCN1A)

CDK:

105091051

VPC:

102524652

BACU:

102998353(SCN1A)

BMUS:

118898430

LVE:	103086512(SCN1A)

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100052059(SCN1A)

EPZ:	103561931(SCN1A)

EAI:	106843368(SCN1A)

MYB:	102244762(SCN1A)

MYD:	102766647(SCN1A)

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:	109374890(SCN1A)

RFQ:

117026204

PALE:

102893777(SCN1A)

PGIG:

120596896(SCN1A)

PVP:	105292089(SCN1A)

RAY:	107521033(SCN1A)

MJV:	108390098(SCN1A)

TOD:	119255889(SCN1A)

SARA:

101549773(SCN1A)

SETR:

126009040(SCN1A)

LAV:	100672780(SCN1A)

TMU:

101344289

ETF:

101644888

DNM:

101441329

MDO:	100016606(SCN1A)

GAS:

SHR:

AFZ:

PCW:

OAA:	100083049(SCN1A)

GGA:	771555(SCN1A)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

120507420(SCN1A)

OTC:

121335437

PRUF:

121356707

GFR:	102041885(SCN1A)

FAB:	101821403(SCN1A)

OMA:

130255471

PHI:	102110251(SCN1A)

PMAJ:

CCAE:

CCW:

CBRC:

ETL:	114073728(SCN1A)

ZAB:

ACHL:

SVG:

MMEA:

HRT:

FPG:	101919476(SCN1A)

FCH:

102051605

CLV:

102093056

EGZ:	104127995(SCN1A)

NNI:	104009974(SCN1A)

PCRI:

PLET:

EHS:

PCAO:

ACUN:

113482219(SCN1A)

TALA:

104358686

PADL:

103918150(SCN1A)

AFOR:

103895330(SCN1A)

ACHC:

115343413(SCN1A)

HALD:

104317982(SCN1A)

HLE:	104831632(SCN1A)

AGEN:

GCL:

CCRI:

CMAC:

MUI:

BREG:

FGA:

LDI:

MNB:

OHA:

NNT:

SHAB:

115609096(SCN1A)

DPUB:

104309259(SCN1A)

PGUU:

104462272(SCN1A)

ACAR:

104529198

CPEA:

104387522

AVIT:

104279063

CVF:	104294910(SCN1A)

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:	112955886(SCN1A)

TGT:

104573475

DNE:	112979697(SCN1A)

SCAM:

104144943(SCN1A)

ASN:

102369842

AMJ:	102572122(SCN1A)

CPOO:

109322525(SCN1A)

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

116819303(SCN1A)

MRV:

120374778

ACS:	100560273(scn1a)

ASAO:

132776561

PVT:	110076882(SCN1A)

SUND:

121931903

PBI:	103062393(SCN1A)

PMUR:

107294405(SCN1A)

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:	113416487 113416543

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:	107114613(SCN1A)

STOW:

EMC:

PMRN:

LRJ:

TCF:

Reference

PMID:20410126

Authors

Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T

Title

A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats.

Journal

J Neurosci 30:5744-53 (2010)
DOI:10.1523/JNEUROSCI.3360-09.2010

Sequence

[hsa:6323]

LinkDB

DBGET integrated database retrieval system