KEGG   ORTHOLOGY: K10631
Entry
K10631                      KO                                     
Symbol
TOPORS
Name
E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
Disease
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10631  TOPORS; E3 ubiquitin-protein ligase Topors
   03036 Chromosome and associated proteins
    K10631  TOPORS; E3 ubiquitin-protein ligase Topors
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K10631  TOPORS; E3 ubiquitin-protein ligase Topors
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10631  TOPORS; E3 ubiquitin-protein ligase Topors
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10631  TOPORS; E3 ubiquitin-protein ligase Topors
  UBL E3 ligases
   K10631  TOPORS; E3 ubiquitin-protein ligase Topors
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Centriole proteins
    K10631  TOPORS; E3 ubiquitin-protein ligase Topors
Cilium and associated proteins [BR:ko03037]
 Primary cilia and associated proteins
  Other primary cilia associated proteins
   K10631  TOPORS; E3 ubiquitin-protein ligase Topors
Other DBs
GO: 0019789
Genes
HSA: 10210(TOPORS)
PTR: 744660(TOPORS)
PPS: 100968575(TOPORS)
GGO: 101132453(TOPORS)
PON: 100443889(TOPORS)
NLE: 100596510(TOPORS)
HMH: 116458230(TOPORS)
MCC: 703930(TOPORS)
MCF: 101926109(TOPORS)
MTHB: 126937381
MNI: 105485640(TOPORS)
CSAB: 103219307(TOPORS)
CATY: 105590094(TOPORS)
PANU: 100997419(TOPORS)
TGE: 112607796(TOPORS)
MLEU: 105539634
RRO: 104655056(TOPORS)
RBB: 108529796(TOPORS)
TFN: 117098705(TOPORS)
PTEH: 111537235(TOPORS)
CANG: 105516440(TOPORS)
CJC: 100409065(TOPORS)
SBQ: 101044570(TOPORS)
CIMI: 108317668(TOPORS)
CSYR: 103263510(TOPORS)
OGA: 100950981(TOPORS)
MMU: 106021(Topors)
MCAL: 110292495(Topors)
MPAH: 110338674(Topors)
RNO: 362501(Topors)
MCOC: 116095819(Topors)
ANU: 117708993(Topors)
MUN: 110561671(Topors)
CGE: 100765733(Topors)
MAUA: 101826727(Topors)
PROB: 127224504(Topors)
PLEU: 114703264(Topors)
MORG: 121458249(Topors)
MFOT: 126503626
AAMP: 119825962(Topors)
NGI: 103748445(Topors)
HGL: 101717472(Topors)
CPOC: 100718772(Topors)
CCAN: 109683804(Topors)
DORD: 105993402(Topors)
DSP: 122120983(Topors)
PLOP: 125362537(Topors)
NCAR: 124964467
MMMA: 107147860(Topors)
OCU: 100352626
OPI: 101527451(TOPORS)
TUP: 102473057(TOPORS)
GVR: 103603407(TOPORS)
CFA: 481577(TOPORS)
CLUD: 112650485(TOPORS)
VVP: 112927560(TOPORS)
VLG: 121495388(TOPORS)
NPO: 129494754(TOPORS)
AML: 100469707(TOPORS)
UMR: 103667022(TOPORS)
UAH: 113260656(TOPORS)
UAR: 123781023(TOPORS)
ELK: 111146292
MPUF: 101689262(TOPORS)
MNP: 132024674(TOPORS)
MLK: 131812514(TOPORS)
NVS: 122917535(TOPORS)
ORO: 101384186(TOPORS)
EJU: 114218161(TOPORS)
ZCA: 113933993(TOPORS) 118357116
MLX: 118018035(TOPORS)
NSU: 110581861(TOPORS)
LWW: 102743961(TOPORS)
FCA: 101096178(TOPORS)
PYU: 121034556(TOPORS)
PCOO: 112855214(TOPORS)
PBG: 122475204(TOPORS)
PVIV: 125150583(TOPORS)
LRUF: 124501235
PTG: 102952491(TOPORS)
PPAD: 109252055(TOPORS)
PUC: 125920663
AJU: 106976056
HHV: 120241731(TOPORS)
BTA: 523321(TOPORS)
BOM: 102278489(TOPORS)
BIU: 109562814(TOPORS)
BBUB: 102390100(TOPORS)
BBIS: 104988317(TOPORS)
CHX: 102183512(TOPORS)
OAS: 101113202(TOPORS)
BTAX: 128052470(TOPORS)
ODA: 120861477(TOPORS)
CCAD: 122453330(TOPORS)
MBEZ: 129557514(TOPORS)
SSC: 100513812(TOPORS)
CFR: 102503809(TOPORS)
CBAI: 105078737(TOPORS)
CDK: 105085564(TOPORS)
VPC: 102535215(TOPORS)
BACU: 103020776(TOPORS)
BMUS: 118896738(TOPORS)
LVE: 103083981(TOPORS)
OOR: 101282585(TOPORS)
DLE: 111163191(TOPORS)
PCAD: 102976456(TOPORS)
PSIU: 116755428(TOPORS)
NASI: 112405428(TOPORS)
ECB: 100053650(TOPORS)
EPZ: 103550254(TOPORS)
EAI: 106841471(TOPORS)
MYB: 102243012(TOPORS)
MYD: 102761471(TOPORS)
MMYO: 118667401(TOPORS)
MLF: 102438748(TOPORS)
PKL: 118716421(TOPORS)
EFUS: 103286488(TOPORS)
MNA: 107544981(TOPORS)
DRO: 112304473(TOPORS)
SHON: 118979881(TOPORS)
AJM: 119060006(TOPORS)
PDIC: 114493840(TOPORS)
PHAS: 123819736(TOPORS)
MMF: 118629714(TOPORS)
PPAM: 129078218(TOPORS)
HAI: 109371520(TOPORS)
RFQ: 117032443(TOPORS)
PALE: 102891385(TOPORS)
PGIG: 120612924(TOPORS)
PVP: 105306406(TOPORS)
RAY: 107502799(TOPORS)
MJV: 108400797(TOPORS)
TOD: 119231289(TOPORS)
SARA: 101541999(TOPORS)
SETR: 126008835(TOPORS)
LAV: 100654398(TOPORS)
TMU: 101340358
ETF: 101664162(TOPORS)
DNM: 101447897(TOPORS)
MDO: 100024201(TOPORS) 103093464
GAS: 123250237(TOPORS)
SHR: 100919314(TOPORS) 105749560
AFZ: 127545981
PCW: 110200845(TOPORS) 110219108
OAA: 100091296(TOPORS)
GGA: 427342(TOPORS)
PCOC: 116239744
MGP: 104915307(TOPORS) 104915314
CJO: 107306589(TOPORS)
TPAI: 128089436(TOPORS) 128089439
LMUT: 125686767
APLA: 101804823(TOPORS)
ACYG: 106043038(TOPORS)
CATA: 118257032(TOPORS)
AFUL: 116500974(TOPORS)
TGU: 100222717(TOPORS) 100225594
LSR: 110467745(TOPORS) 110467767
SCAN: 103821823(TOPORS) 103821847
PMOA: 120513643(TOPORS)
OTC: 121333648(TOPORS) 121333653
PRUF: 121363716(TOPORS)
GFR: 102038580(TOPORS) 102040902
FAB: 101814774(TOPORS) 101815563
OMA: 130265269(TOPORS)
PHI: 102099109 102111406(TOPORS)
PMAJ: 107198428(TOPORS) 107215857
CCAE: 111941186(TOPORS) 111941231
CCW: 104690485(TOPORS)
CBRC: 103611621(TOPORS)
ETL: 114073199(TOPORS)
ZAB: 102064208(TOPORS)
ACHL: 103798744(TOPORS)
SVG: 106857809(TOPORS)
MMEA: 130572921(TOPORS)
HRT: 120765779(TOPORS)
FPG: 101919954(TOPORS)
FCH: 102059192(TOPORS)
CLV: 102085254(TOPORS)
EGZ: 104123054(TOPORS)
NNI: 104019833(TOPORS)
PCRI: 104026144(TOPORS)
PLET: 104615700 104626399(TOPORS)
EHS: 104504930(TOPORS)
PCAO: 104040543(TOPORS)
ACUN: 113488204 113490238(TOPORS)
TALA: 104359131(TOPORS)
PADL: 103921053(TOPORS)
AFOR: 103904717(TOPORS)
ACHC: 115337148(TOPORS)
HALD: 104312870(TOPORS)
HLE: 104838405(TOPORS)
AGEN: 126035866
GCL: 127027811
CCRI: 104161740(TOPORS)
CSTI: 104551959(TOPORS)
CMAC: 104474999(TOPORS)
MUI: 104535287(TOPORS)
BREG: 104631178(TOPORS)
FGA: 104071670(TOPORS)
GSTE: 104253333(TOPORS)
LDI: 104341668(TOPORS)
MNB: 103779827(TOPORS)
NNT: 104400971(TOPORS)
SHAB: 115601318(TOPORS)
DPUB: 104301708(TOPORS)
ACAR: 104517699(TOPORS)
CPEA: 104393431(TOPORS)
AVIT: 104267771(TOPORS)
CVF: 104296047(TOPORS)
RTD: 128902727
CUCA: 104059642(TOPORS)
TEO: 104374823(TOPORS)
BRHI: 104490897(TOPORS)
AAM: 106496783(TOPORS)
AROW: 112975974(TOPORS)
NPD: 112948521(TOPORS)
TGT: 104572666(TOPORS)
DNE: 112993624(TOPORS)
SCAM: 104142591(TOPORS)
ASN: 102367948(TOPORS) 102386226
AMJ: 102565050(TOPORS) 102569358
CPOO: 109323318 109323599(TOPORS)
GGN: 109297324(TOPORS)
PSS: 102444441(TOPORS) 112545323
CMY: 102935835(TOPORS)
CCAY: 125637339(TOPORS)
DCC: 119855786(TOPORS)
CPIC: 101953429(TOPORS)
TST: 117879028(TOPORS)
CABI: 116828920(TOPORS)
MRV: 120408052(TOPORS) 120408301
ACS: 100564436 100565993(topors)
PVT: 110085167
PMUR: 107296931(TOPORS)
TSR: 106547551(TOPORS) 106550380
APRI: 131190144(TOPORS)
PTEX: 113444624(TOPORS)
NSS: 113415057(TOPORS)
VKO: 123022249(TOPORS) 123030180
GJA: 107113237(TOPORS)
STOW: 125436849(TOPORS) 125437059
EMC: 129335212(TOPORS)
XLA: 108706920(topors.S) 108713581(topors.L)
XTR: 734040(topors)
NPR: 108785413(TOPORS)
RTEM: 120945837(TOPORS)
BBUF: 120989263(TOPORS)
BGAR: 122921474(TOPORS)
MUO: 115463330(TOPORS)
GSH: 117351404(TOPORS)
DRE: 324197(toporsa) 796087(toporsb)
PTET: 122334539(toporsb) 122348120(toporsa)
LROH: 127154767(toporsb) 127171923(toporsa)
OMC: 131532614(toporsb) 131540266(toporsa)
PPRM: 120484095(toporsb) 120494910(toporsa)
RKG: 130071739(toporsb) 130099424(toporsa)
MAMB: 125259772 125272437(toporsa)
TROS: 130552518(toporsa)
TDW: 130408875(toporsb) 130434091(toporsa)
IPU: 108263777(toporsa) 108275721
IFU: 128606162(toporsa) 128619863
SMEO: 124397077(toporsa) 124398973(toporsb)
TFD: 113646592(toporsa) 113652981(toporsb)
TVC: 132847743(toporsa) 132862192
CMAO: 118810752(toporsa) 118822676(toporsb)
CHAR: 105904024(toporsa)
TRU: 101063171 101073167(topors)
TFS: 130523311 130527650(toporsa)
NCC: 104942309 104965089(topors)
TBEN: 117480787 117482326(toporsa)
CGOB: 115005661 115009642(topors)
PGEO: 117449583(toporsa) 117463746
GACU: 117555301(toporsa)
EMAC: 134864889(toporsa) 134876088
ELY: 117245812 117255363(toporsa)
EFO: 125883729 125886098(toporsa)
PLEP: 121942631(toporsa) 121962074
SLUC: 116034287(toporsa) 116064515
ECRA: 117958027(toporsa)
ESP: 116697832(topors)
PFLV: 114546122 114568206(topors)
GAT: 120813229 120825579(toporsa)
PPUG: 119218352(toporsa) 119221730
AFB: 129093122 129095857(toporsa)
CLUM: 117730807(toporsa) 117747909
PSWI: 130189598(toporsa) 130212188
MSAM: 119898942(toporsa) 119911998
SCHU: 122872949(toporsa)
CUD: 121504390 121507720(toporsa)
ALAT: 119018207(toporsa) 119026681
MZE: 101472227(topors) 101475943
ONL: 100699507 102082542(topors)
OAU: 116330077(toporsa) 116335892
OLA: 101170493(topors) 111949311
OML: 112155854 112157428(toporsa)
CSAI: 133420906 133436892(toporsa)
XMA: 102226089 102237034(topors)
XCO: 114144720(topors) 114157596
XHE: 116720435(topors) 116732559
PRET: 103466431(topors) 103480989
PFOR: 103148473(topors) 103149117
PLAI: 106949619(topors) 106958968
PMEI: 106919332(topors) 106928566
GAF: 122820794 122829490(toporsa)
PPRL: 129367146(toporsa)
CTUL: 119773766 119796281(toporsa)
GMU: 124868111(toporsa) 124881285
NFU: 107375283(topors) 107396728
KMR: 108228415 108230904(toporsa)
ALIM: 106535482(topors)
NWH: 119417481 119430752(toporsa)
AOCE: 111579686 111583300(topors)
MCEP: 125004431
CSEM: 103383532(topors) 103390081
POV: 109638368(topors) 109645481
SSEN: 122766813 122771676(toporsa)
HHIP: 117751824 117761711(toporsa)
HSP: 118102870 118124927(toporsa)
SMAU: 118312538(toporsa) 118319821
LCF: 108892366 108896626(toporsa)
SDU: 111233149 111236604(topors)
SLAL: 111661036 111670396(topors)
XGL: 120797221 120799995(toporsa)
SSCV: 125969034
SBIA: 133494672 133505964(toporsa)
PEE: 133397558 133404221(toporsa)
PTAO: 133472942 133476824(toporsa)
BPEC: 110165360(topors) 110170295
MALB: 109961410(topors)
BSPL: 114843935
SJO: 128378536(toporsa) 128384043
OTW: 112240920(toporsa)
OGO: 124013900 124019040(toporsa)
ONE: 115115715
OKE: 118375752(toporsa) 118376694
SNH: 120034974(toporsa) 120049435
CCLU: 121556736(toporsa) 121571001
SFM: 108925972(topors)
PKI: 111859278(topors)
AANG: 118226892(toporsa) 118231115
LOC: 102686125(topors)
PSPA: 121296200(toporsa) 121323843
PSEX: 120532785(toporsa)
LCM: 102361384(TOPORS)
CMK: 103187212(toporsa)
RTP: 109926961
CPLA: 122562955
HOC: 132824749
LERI: 129695482(toporsa)
PMRN: 116941969(TOPORS)
BFO: 118432400
BBEL: 109486063
CIN: 100178429
SCLV: 120334884
LPIC: 129271221
APLC: 110977760
SKO: 100376440
DME: Dmel_CG15104(Topors)
DER: 6547127
DSI: Dsimw501_GD11423(Dsim_GD11423)
DSR: 110184077
DPO: 4804065
DPE: 6590072
DGR: 6559982
DAZ: 108616973
DNV: 108653329
DHE: 111592402
CCAT: 101454542
BOD: 106627832
AOQ: 129244446
SCAC: 106088994
LCQ: 111686713
LSQ: 119612112
ECOE: 129949809
CLON: 129607311
AGA: 1276499
ACOZ: 120949765
AARA: 120895876
ASTE: 118511475
AAG: 5570941
AALB: 109406055
CPII: 120428687
CNS: 116343612
BCOO: 119081737
AME: 410541
ACER: 108001034
ALAB: 122710958
ADR: 102679334
AFLR: 100864130
BIM: 100742727
BBIF: 117205807
BVK: 117243335
BVAN: 117155353
BTER: 100646483
BAFF: 126923386
BPYO: 122574605
BPAS: 132913348
FVI: 122527003
CCAL: 108627844
OBB: 114873861
OLG: 117604522
MGEN: 117226462
NMEA: 116426965
SOC: 105205269
MPHA: 105839302
AEC: 105149332
ACEP: 105621915
PBAR: 105422461
VEM: 105560654
HST: 105183277
DQU: 106743359
CFO: 105255543
LHU: 105675483
PGC: 109853154
OBO: 105281901
PCF: 106784767
PFUC: 122523133
VPS: 122629335
VCRB: 124423641
VVE: 124949751
NVI: 100116176
CSOL: 105363658
TPRE: 106652512
MDL: 103576064
CGLO: 123259774
FAS: 105272605
DAM: 107043136
AGIF: 122853302
CCIN: 107263090
TCA: 103313725
DPA: 109532721
SOY: 115885336
ATD: 109594369
CSET: 123307456
AGB: 108909772
NVL: 108559279
APLN: 108742285
PPYR: 116158770
OTU: 111429156
MSEX: 115448666
BANY: 112044237
NIQ: 126772408
VCD: 124531397
PMAC: 106709299
PXU: 106124615
PRAP: 111003876
ZCE: 119829481
AAGE: 121730074
HAW: 110378539(Topors)
HZE: 124634251
TNL: 113501934
SLIU: 111353437
OFU: 114351923
DNX: 107173962
AGS: 114119895
RMD: 113549707
BTAB: 109037957
CLEC: 106662124
HHAL: 106679935
NLU: 111053780
FOC: 113210918
TPAL: 117642185
ZNE: 110838243
CSEC: 111863767
BROR: 134532916
FCD: 110862949
DMK: 116925427
DPZ: 124315176
PVM: 113814491
PJA: 122245612
PCHN: 125025613
HAME: 121875671
PCLA: 123756173
PTRU: 123519053
HAZT: 108683268
LSM: 121114402
RMP: 119181415
VJA: 111260045
TUT: 107371109
DPTE: 113790905
DFR: 124500403
CSCU: 111613910
PTEP: 107439528
PCAN: 112573152
BGT: 106055510
HRF: 124135621
HRJ: 124277343
CRG: 105320133
MYI: 110453122
PMAX: 117326030
MMER: 123525505
OBI: 106880797
OSN: 115219707
LAK: 106173142
EPA: 110239761
ATEN: 116307514
ADF: 107332408
AMIL: 114952945
PDAM: 113666751
SPIS: 111342564
DGT: 114526237
HMG: 100207129
AQU: 100633818
CNB: CNBC0230
ABP: AGABI1DRAFT132816(AGABI1DRAFT_132816)
SCM: SCHCO_02629162(SCHCODRAFT_02629162)
DFA: DFA_03703
 » show all
Reference
  Authors
Chu D, Kakazu N, Gorrin-Rivas MJ, Lu HP, Kawata M, Abe T, Ueda K, Adachi Y
  Title
Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence.
  Journal
J Biol Chem 276:14004-13 (2001)
DOI:10.1074/jbc.M010262200
  Sequence
[hsa:10210]
Reference
  Authors
Marshall H, Bhaumik M, Aviv H, Moore D, Yao M, Dutta J, Rahim H, Gounder M, Ganesan S, Saleem A, Rubin E
  Title
Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
  Journal
BMC Mol Biol 11:31 (2010)
DOI:10.1186/1471-2199-11-31
  Sequence
[mmu:106021]
Reference
  Authors
Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A, Bhattacharya SS
  Title
TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
  Journal
Hum Mol Genet 20:975-87 (2011)
DOI:10.1093/hmg/ddq543
  Sequence
[hsa:10210] [mmu:106021]
Reference
  Authors
Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H
  Title
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
  Journal
Oncogene 24:3385-96 (2005)
DOI:10.1038/sj.onc.1208554
  Sequence
[hsa:10210] [mmu:106021]
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