KEGG   PATHWAY: hsa05207
Entry
hsa05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Homo sapiens (human)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
hsa05207  Chemical carcinogenesis - receptor activation
hsa05207

Network
  Element
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01341  NNK/NNN to Jak-STAT signaling pathway
N01342  Nicotine to Jak-STAT signaling pathway
N01344  NNK/NNN to RAS-ERK signaling pathway
N01346  Nicotine/NNK to cAMP signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01352  BPA to RAS-ERK signaling pathway
N01353  E2 to RAS-ERK signaling pathway
N01354  BPA to RAS-ERK signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01361  P4/MPA to PR-RAS-ERK signaling pathway
N01363  P4/MPA to nuclear-initiated progesterone signaling pathway
N01364  E2 to nuclear-initiated estrogen signaling pathway
N01365  TCDD to Ahr signaling pathway
N01366  BaP to Ahr signaling pathway
N01367  PCB to Ahr signaling pathway
N01368  HCB to Ahr signaling pathway
Drug
D11045  Darolutamide (JAN/USAN/INN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
408  ARRB1; arrestin beta 1 [KO:K04439]
409  ARRB2; arrestin beta 2 [KO:K04439]
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5925  RB1; RB transcriptional corepressor 1 [KO:K06618]
1869  E2F1; E2F transcription factor 1 [KO:K17454]
332  BIRC5; baculoviral IAP repeat containing 5 [KO:K08731]
331  XIAP; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
990  CDC6; cell division cycle 6 [KO:K02213]
993  CDC25A; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
3717  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
6774  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
595  CCND1; cyclin D1 [KO:K04503]
1137  CHRNA4; cholinergic receptor nicotinic alpha 4 subunit [KO:K04806]
1141  CHRNB2; cholinergic receptor nicotinic beta 2 subunit [KO:K04813]
1136  CHRNA3; cholinergic receptor nicotinic alpha 3 subunit [KO:K04805]
1143  CHRNB4; cholinergic receptor nicotinic beta 4 subunit [KO:K04815]
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
778  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
779  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
773  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2475  MTOR; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
3265  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
3845  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
4893  NRAS; NRAS proto-oncogene, GTPase [KO:K07828]
5604  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
4609  MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377]
596  BCL2; BCL2 apoptosis regulator [KO:K02161]
5578  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
7422  VEGFA; vascular endothelial growth factor A [KO:K05448]
2247  FGF2; fibroblast growth factor 2 [KO:K18497]
153  ADRB1; adrenoceptor beta 1 [KO:K04141]
154  ADRB2; adrenoceptor beta 2 [KO:K04142]
155  ADRB3; adrenoceptor beta 3 [KO:K04143]
2778  GNAS; GNAS complex locus [KO:K04632]
107  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
108  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
109  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
115  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
1385  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
1386  ATF2; activating transcription factor 2 [KO:K04450]
468  ATF4; activating transcription factor 4 [KO:K04374]
10488  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
90993  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
64764  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
84699  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
148327  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
9586  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
1388  ATF6B; activating transcription factor 6 beta [KO:K09049]
2770  GNAI1; G protein subunit alpha i1 [KO:K04630]
2773  GNAI3; G protein subunit alpha i3 [KO:K04630]
2771  GNAI2; G protein subunit alpha i2 [KO:K04630]
572  BAD; BCL2 associated agonist of cell death [KO:K02158]
55584  CHRNA9; cholinergic receptor nicotinic alpha 9 subunit [KO:K04810]
6197  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
6195  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
6196  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
27330  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
2099  ESR1; estrogen receptor 1 [KO:K08550]
2100  ESR2; estrogen receptor 2 [KO:K08551]
7421  VDR; vitamin D receptor [KO:K08539]
896  CCND3; cyclin D3 [KO:K10152]
1956  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2885  GRB2; growth factor receptor bound protein 2 [KO:K04364]
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
1978  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
6198  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
6199  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
164091  PAQR7; progestin and adipoQ receptor family member 7 [KO:K25039]
85315  PAQR8; progestin and adipoQ receptor family member 8 [KO:K25040]
54852  PAQR5; progestin and adipoQ receptor family member 5 [KO:K25041]
5241  PGR; progesterone receptor [KO:K08556]
8600  TNFSF11; TNF superfamily member 11 [KO:K05473]
6776  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
6777  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
604  BCL6; BCL6 transcription repressor [KO:K15618]
688  KLF5; KLF transcription factor 5 [KO:K09206]
9314  KLF4; KLF transcription factor 4 [KO:K17846]
7471  WNT1; Wnt family member 1 [KO:K03209]
4853  NOTCH2; notch receptor 2 [KO:K20994]
182  JAG1; jagged canonical Notch ligand 1 [KO:K06052]
406933  MIR141; microRNA 141 [KO:K17018]
407021  MIR29A; microRNA 29a [KO:K16995]
407024  MIR29B1; microRNA 29b-1 [KO:K16996]
407025  MIR29B2; microRNA 29b-2 [KO:K16996]
407026  MIR29C; microRNA 29c [KO:K16997]
367  AR; androgen receptor [KO:K08557]
406881  MIRLET7A1; microRNA let-7a-1 [KO:K16980]
406882  MIRLET7A2; microRNA let-7a-2 [KO:K16980]
406883  MIRLET7A3; microRNA let-7a-3 [KO:K16980]
406884  MIRLET7B; microRNA let-7b [KO:K16980]
406886  MIRLET7D; microRNA let-7d [KO:K16980]
406887  MIRLET7E; microRNA let-7e [KO:K16980]
406888  MIRLET7F1; microRNA let-7f-1 [KO:K16980]
406889  MIRLET7F2; microRNA let-7f-2 [KO:K16980]
406890  MIRLET7G; microRNA let-7g [KO:K16980]
406891  MIRLET7I; microRNA let-7i [KO:K16980]
1950  EGF; epidermal growth factor [KO:K04357]
2248  FGF3; fibroblast growth factor 3 [KO:K04358]
2249  FGF4; fibroblast growth factor 4 [KO:K04358]
8822  FGF17; fibroblast growth factor 17 [KO:K04358]
2251  FGF6; fibroblast growth factor 6 [KO:K04358]
2252  FGF7; fibroblast growth factor 7 [KO:K04358]
2253  FGF8; fibroblast growth factor 8 [KO:K04358]
2254  FGF9; fibroblast growth factor 9 [KO:K04358]
2255  FGF10; fibroblast growth factor 10 [KO:K04358]
8823  FGF16; fibroblast growth factor 16 [KO:K04358]
2250  FGF5; fibroblast growth factor 5 [KO:K04358]
8817  FGF18; fibroblast growth factor 18 [KO:K04358]
26281  FGF20; fibroblast growth factor 20 [KO:K04358]
27006  FGF22; fibroblast growth factor 22 [KO:K04358]
10683  DLL3; delta like canonical Notch ligand 3 [KO:K06051]
28514  DLL1; delta like canonical Notch ligand 1 [KO:K06051]
54567  DLL4; delta like canonical Notch ligand 4 [KO:K06051]
10728  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
23746  AIPL1; aryl hydrocarbon receptor interacting protein like 1 [KO:K17767]
9049  AIP; aryl hydrocarbon receptor interacting protein [KO:K17767]
196  AHR; aryl hydrocarbon receptor [KO:K09093]
3320  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
3326  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
7184  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
3836  KPNA1; karyopherin subunit alpha 1 [KO:K23940]
3838  KPNA2; karyopherin subunit alpha 2 [KO:K15043]
402569  KPNA7; karyopherin subunit alpha 7 [KO:K15043]
3839  KPNA3; karyopherin subunit alpha 3 [KO:K23583]
3840  KPNA4; karyopherin subunit alpha 4 [KO:K23583]
23633  KPNA6; karyopherin subunit alpha 6 [KO:K15042]
3841  KPNA5; karyopherin subunit alpha 5 [KO:K15042]
3837  KPNB1; karyopherin subunit beta 1 [KO:K14293]
405  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1 [KO:K07408] [EC:1.14.14.1]
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1 [KO:K07410] [EC:1.14.14.1]
2052  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
2053  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
79852  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
253152  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
221357  GSTA5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
2939  GSTA2; glutathione S-transferase alpha 2 [KO:K00799] [EC:2.5.1.18]
2941  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
119391  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
2948  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene) [KO:K00799] [EC:2.5.1.18]
2952  GSTT1; glutathione S-transferase theta 1 [KO:K00799] [EC:2.5.1.18]
2947  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
4257  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
4259  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
2944  GSTM1; glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
2949  GSTM5; glutathione S-transferase mu 5 [KO:K00799] [EC:2.5.1.18]
4258  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
2938  GSTA1; glutathione S-transferase alpha 1 [KO:K00799] [EC:2.5.1.18]
2946  GSTM2; glutathione S-transferase mu 2 [KO:K00799] [EC:2.5.1.18]
2940  GSTA3; glutathione S-transferase alpha 3 [KO:K00799] [EC:2.5.1.18]
9446  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
653689  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
10941  UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
1555  CYP2B6; cytochrome P450 family 2 subfamily B member 6 [KO:K17709] [EC:1.14.14.-]
9970  NR1I3; nuclear receptor subfamily 1 group I member 3 [KO:K08541]
6256  RXRA; retinoid X receptor alpha [KO:K08524]
6257  RXRB; retinoid X receptor beta [KO:K08525]
6258  RXRG; retinoid X receptor gamma [KO:K08526]
1576  CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
5465  PPARA; peroxisome proliferator activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
  Authors
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
  Journal
Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
Reference
PMID:20953833
  Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
  Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
  Journal
Breast Cancer Res Treat 129:331-45 (2011)
DOI:10.1007/s10549-010-1209-0
Reference
PMID:16421368
  Authors
Yager JD, Davidson NE
  Title
Estrogen carcinogenesis in breast cancer.
  Journal
N Engl J Med 354:270-82 (2006)
DOI:10.1056/NEJMra050776
Reference
PMID:29229539
  Authors
Murata M, Kang JH
  Title
Bisphenol A (BPA) and cell signaling pathways.
  Journal
Biotechnol Adv 36:311-327 (2018)
DOI:10.1016/j.biotechadv.2017.12.002
Reference
PMID:28251049
  Authors
Wang Z, Liu H, Liu S
  Title
Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer.
  Journal
Adv Sci (Weinh) 4:1600248 (2017)
DOI:10.1002/advs.201600248
Reference
PMID:28426875
  Authors
Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP, Devi GR
  Title
Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
  Journal
Carcinogenesis 38:252-260 (2017)
DOI:10.1093/carcin/bgx003
Reference
PMID:29769245
  Authors
Chen QY, Costa M
  Title
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
  Journal
Mol Pharmacol 94:784-792 (2018)
DOI:10.1124/mol.118.112268
Reference
PMID:32867363
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
Reference
PMID:26265122
  Authors
Finlay-Schultz J, Sartorius CA
  Title
Steroid hormones, steroid receptors, and breast cancer stem cells.
  Journal
J Mammary Gland Biol Neoplasia 20:39-50 (2015)
DOI:10.1007/s10911-015-9340-5
Reference
PMID:27368976
  Authors
Valadez-Cosmes P, Vazquez-Martinez ER, Cerbon M, Camacho-Arroyo I
  Title
Membrane progesterone receptors in reproduction and cancer.
  Journal
Mol Cell Endocrinol 434:166-75 (2016)
DOI:10.1016/j.mce.2016.06.027
Reference
PMID:33014829
  Authors
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
PMID:25568920
  Authors
Murray IA, Patterson AD, Perdew GH
  Title
Aryl hydrocarbon receptor ligands in cancer: friend and foe.
  Journal
Nat Rev Cancer 14:801-14 (2014)
DOI:10.1038/nrc3846
Reference
PMID:30003042
  Authors
Larigot L, Juricek L, Dairou J, Coumoul X
  Title
AhR signaling pathways and regulatory functions.
  Journal
Biochim Open 7:1-9 (2018)
DOI:10.1016/j.biopen.2018.05.001
Reference
PMID:27980293
  Authors
Kawajiri K, Fujii-Kuriyama Y
  Title
The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance.
  Journal
Exp Anim 66:75-89 (2017)
DOI:10.1538/expanim.16-0092
Reference
PMID:31552251
  Authors
Hidaka T, Fujimura T, Aiba S
  Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
  Journal
Front Med (Lausanne) 6:194 (2019)
DOI:10.3389/fmed.2019.00194
Reference
PMID:15900503
  Authors
Mandal PK
  Title
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.
  Journal
J Comp Physiol B 175:221-30 (2005)
DOI:10.1007/s00360-005-0483-3
Reference
PMID:30951959
  Authors
Miret NV, Pontillo CA, Zarate LV, Kleiman de Pisarev D, Cocca C, Randi AS
  Title
Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.
  Journal
Environ Res 173:330-341 (2019)
DOI:10.1016/j.envres.2019.03.054
Reference
PMID:32526215
  Authors
Zarate LV, Pontillo CA, Espanol A, Miret NV, Chiappini F, Cocca C, Alvarez L, de Pisarev DK, Sales ME, Randi AS
  Title
Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor.
  Journal
Toxicol Appl Pharmacol 401:115093 (2020)
DOI:10.1016/j.taap.2020.115093
Reference
PMID:25257533
  Authors
L'Heritier F, Marques M, Fauteux M, Gaudreau L
  Title
Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis.
  Journal
Int J Mol Sci 15:17148-61 (2014)
DOI:10.3390/ijms150917148
Reference
PMID:17189671
  Authors
Kitamura M, Kasai A
  Title
Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway.
  Journal
Cancer Lett 252:184-94 (2007)
DOI:10.1016/j.canlet.2006.11.015
Reference
PMID:26600562
  Authors
Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K
  Title
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
  Journal
Environ Health Perspect 124:713-21 (2016)
DOI:10.1289/ehp.1509912
Reference
PMID:31366862
  Authors
Yoshinari K
  Title
Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis.
  Journal
Biol Pharm Bull 42:1243-1252 (2019)
DOI:10.1248/bpb.b19-00267
Reference
PMID:26136231
  Authors
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I
  Title
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.
  Journal
Toxicol Sci 147:339-49 (2015)
DOI:10.1093/toxsci/kfv134
Reference
PMID:20414453
  Authors
Pyper SR, Viswakarma N, Yu S, Reddy JK
  Title
PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
  Journal
Nucl Recept Signal 8:e002 (2010)
DOI:10.1621/nrs.08002
Reference
PMID:20049115
  Authors
Guyton KZ, Chiu WA, Bateson TF, Jinot J, Scott CS, Brown RC, Caldwell JC
  Title
A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.
  Journal
Environ Health Perspect 117:1664-72 (2009)
DOI:10.1289/ehp.0900758
Related
pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa03320  PPAR signaling pathway
hsa04010  MAPK signaling pathway
hsa04024  cAMP signaling pathway
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa04915  Estrogen signaling pathway
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05206  MicroRNAs in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
LinkDB

DBGET integrated database retrieval system