KEGG   PATHWAY: achc05168
Entry
achc05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Aquila chrysaetos chrysaetos (golden eagle)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
achc05168  Herpes simplex virus 1 infection
achc05168

Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115347943  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
115343425  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
115335375  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
115349818  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
115350500  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
115348471  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
115337413  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
115341473  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
115353209  inhibitor of apoptosis protein isoform X1 [KO:K16060]
115344495  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
115345970  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
115343160  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
115345001  ITGB3; integrin beta-3 [KO:K06493]
115339513  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
115337276  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
115335451  CARD9; caspase recruitment domain-containing protein 9 isoform X8 [KO:K12794]
115337094  interferon-like [KO:K05415]
115337096  interferon-like [KO:K05415]
115337097  interferon-like [KO:K05415]
115338264  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
115348358  C3; complement C3 [KO:K03990]
115335382  C5; complement C5 isoform X1 [KO:K03994]
115339865  toll-like receptor 2 type-1 [KO:K10159]
115339882  TLR2; toll-like receptor 2 [KO:K10159]
115339371  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
115352198  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
115345882  TLR3; toll-like receptor 3 isoform X2 [KO:K05401]
115349277  TICAM1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
115341041  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115353383  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
115335051  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115352340  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
115345137  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
115350114  interleukin-1 beta-like isoform X1 [KO:K04519]
115347274  C-C motif chemokine 5-like [KO:K12499]
115339802  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
115347215  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
115334335  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
115336860  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
115342625  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
115344346  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
115352265  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
115335388  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
115336293  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
115336480  interferon epsilon-like [KO:K05414]
115350836  CGAS; cyclic GMP-AMP synthase isoform X3 [KO:K17834] [EC:2.7.7.86]
115334319  STING1; stimulator of interferon genes protein isoform X2 [KO:K12654]
115350480  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
115337541  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
115346179  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
115335755  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
115350100  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
115343397  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
115349570  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X2 [KO:K16196] [EC:2.7.11.1]
115348312  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
115345791  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
115350903  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
115349414  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
115350970  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
115347334  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
115348753  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
115352662  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
115343546  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
115345092  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
115343845  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
115343634  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
115341005  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
115349347  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
115348242  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
115342511  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
115351351  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
115350896  zinc finger protein 883-like [KO:K09228]
115337896  zinc finger protein 79-like [KO:K09228]
115338193  zinc finger protein 883-like isoform X1 [KO:K09228]
115338963  zinc finger protein 777-like isoform X2 [KO:K09228]
115338967  zinc finger protein 777-like [KO:K09228]
115338968  zinc finger protein 777-like isoform X1 [KO:K09228]
115338971  zinc finger protein 282-like [KO:K09228]
115338978  zinc finger protein 777-like isoform X1 [KO:K09228]
115352432  zinc finger protein 239-like [KO:K09228]
115351234  zinc finger protein 91-like [KO:K09228]
115336262  IFNG; interferon gamma [KO:K04687]
115344821  IFNGR1; interferon gamma receptor 1 [KO:K05132]
115343830  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
115337362  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
115341086  PML; protein PML [KO:K10054] [EC:2.3.2.-]
115342201  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
115338299  TAP1; antigen peptide transporter 1 isoform X3 [KO:K05653] [EC:7.4.2.14]
115338305  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
115341389  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
115349694  CALR3; calreticulin-3 [KO:K08057]
115337997  CALR; calreticulin [KO:K08057]
115338300  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
115338306  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
115341884  B2M; beta-2-microglobulin [KO:K08055]
115338200  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
115338201  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
115338202  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
115338203  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
115338204  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
115338205  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
115338208  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
115338209  class II histocompatibility antigen, M alpha chain isoform X1 [KO:K06752]
115334282  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
115347173  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
115347305  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
115342450  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
115349575  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
115337134  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121233034  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115348975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115350251  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115338049  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115338050  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115347910  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115334918  TSC1; hamartin isoform X1 [KO:K07206]
115335525  TSC2; tuberin isoform X1 [KO:K07207]
115339861  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
115342569  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
115350303  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
115334812  SRPK1; SRSF protein kinase 1 isoform X2 [KO:K15409] [EC:2.7.11.1]
115347111  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
115342200  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
115335174  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
115351136  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
115339216  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
115351900  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
115333770  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
115338612  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
115338701  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
115338460  NXF1; nuclear RNA export factor 1 [KO:K14284]
115341986  ALYREF; THO complex subunit 4 [KO:K12881]
115349144  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115348644  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
115343515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
115345654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
115351998  FADD; FAS-associated death domain protein [KO:K02373]
115343326  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115342550  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115352740  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
115335157  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
115353069  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
115339188  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
115339645  cytochrome c [KO:K08738]
115336106  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
115343190  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
115337302  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
achc03040  Spliceosome
achc03050  Proteasome
achc04115  p53 signaling pathway
achc04210  Apoptosis
achc04620  Toll-like receptor signaling pathway
achc04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
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