KEGG   PATHWAY: anu00983
Entry
anu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Arvicanthis niloticus (African grass rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
anu00983  Drug metabolism - other enzymes
anu00983

Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117695319  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
117693339  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
117720427  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
117707548  Gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
117714360  Tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
117716905  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117703815  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
117722882  carboxylesterase 1D [KO:K01044] [EC:3.1.1.1]
117722884  carboxylesterase 1E isoform X1 [KO:K01044] [EC:3.1.1.1]
117722885  carboxylesterase 1C [KO:K01044] [EC:3.1.1.1]
117722886  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
117723120  carboxylesterase 1F-like isoform X1 [KO:K01044] [EC:3.1.1.1]
117723470  LOW QUALITY PROTEIN: carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
117723036  carboxylesterase 1E-like isoform X1 [KO:K01044] [EC:3.1.1.1]
117723035  liver carboxylesterase 1 [KO:K01044] [EC:3.1.1.1]
117723174  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
117722901  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722902  acylcarnitine hydrolase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722903  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722904  pyrethroid hydrolase Ces2e isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722905  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722906  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117723501  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
117722348  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
117722698  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
117722699  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
117722733  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
117722735  UDP-glucuronosyltransferase 1-1 isoform X1 [KO:K00699] [EC:2.4.1.17]
117722736  UDP-glucuronosyltransferase 1-5-like [KO:K00699] [EC:2.4.1.17]
117712352  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
117712566  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
117712567  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
117712689  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
117712751  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
117712771  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
117712815  UDP-glucuronosyltransferase 2B1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
117712837  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
117712845  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
117712855  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
117698310  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
117709099  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
117718466  Tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
117707855  Dpyd; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
117718657  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
117724453  Upb1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
117712781  Upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
117704407  Upp2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
117716137  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
117702937  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
117723078  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
117710978  Tk1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
117718115  Umps; uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
117701581  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
117709254  Cmpk1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
117713499  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
117717299  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117719023  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
117711547  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
117716085  Nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
117693833  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
117701571  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
117710483  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
117710484  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
117710647  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
117704680  Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
117711028  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
117722081  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
117721345  arylamine N-acetyltransferase 3-like [KO:K00622] [EC:2.3.1.5]
117721637  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
117721644  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
117721781  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
117715822  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
117704700  Gsto2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
117704706  Gsto1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
117722371  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
117722373  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
117722423  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
117722532  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
117715441  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
117722661  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
117712654  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
117712712  glutathione S-transferase alpha-2-like [KO:K00799] [EC:2.5.1.18]
117716150  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
117706587  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
117706588  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
117706589  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
117706590  glutathione S-transferase Mu 2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
117706591  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
117706595  Gstm4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
117724528  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
117724531  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
117724532  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
117707482  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
117724949  glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
117707765  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
117712791  glutathione S-transferase alpha-2 [KO:K00799] [EC:2.5.1.18]
117722448  glutathione S-transferase P 2-like [KO:K23790] [EC:2.5.1.18]
117698262  glutathione S-transferase P 1 [KO:K23790] [EC:2.5.1.18]
117698288  glutathione S-transferase P 1 isoform X1 [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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