KEGG   PATHWAY: apla04145
Entry
apla04145                   Pathway                                
Name
Phagosome - Anas platyrhynchos (mallard)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
apla04145  Phagosome
apla04145

Other DBs
GO: 0045335
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101789604  [KO:K06752]
101789692  TLR1-A; toll-like receptor 1 precursor [KO:K10169]
101789737  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101789931  RAB5A; ras-related protein Rab-5A [KO:K07887]
101790497  [KO:K06751]
101790910  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
101791167  STX18; syntaxin-18 [KO:K08492]
101791327  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
101791674  [KO:K06856]
101791786  TLR2; toll-like receptor 2 precursor [KO:K10159]
101791899  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
101791910  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
101791982  C1R; LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
101792171  [KO:K21421] [EC:1.-.-.-]
101792180  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
101792330  STX12; syntaxin-12 [KO:K13813]
101792552  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101792649  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101792739  [KO:K05692]
101792849  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101793156  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
101793322  THBS1; thrombospondin-1 [KO:K16857]
101793615  C3; complement C3 [KO:K03990]
101793816  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101793897  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101794496  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101794564  CTSS; cathepsin S isoform X2 [KO:K01368] [EC:3.4.22.27]
101794597  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
101794894  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
101795078  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
101795300  TUBB4B; tubulin beta-4B chain [KO:K07375]
101795466  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
101795602  [KO:K07374]
101795907  ITGB5; integrin beta-5 isoform X2 [KO:K06588]
101796323  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
101796495  CD36; LOW QUALITY PROTEIN: platelet glycoprotein 4 [KO:K06259]
101796803  ITGB2; integrin beta-2 [KO:K06464]
101797091  [KO:K05654] [EC:7.4.2.14]
101797289  [KO:K07374]
101797294  SFTPA; pulmonary surfactant-associated protein A [KO:K10067]
101797295  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
101797299  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
101797467  MBL; mannose-binding protein [KO:K03991]
101797534  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101797680  [KO:K05653] [EC:7.4.2.14]
101797964  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
101798359  RAB7B; ras-related protein Rab-7b [KO:K07898]
101798656  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
101798684  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101798729  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101798761  [KO:K13883]
101798766  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101798773  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101798784  [KO:K04391]
101799031  STX7; syntaxin-7 [KO:K08488]
101799077  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101799162  COLEC11; collectin-11 isoform X1 [KO:K10066]
101799282  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101799388  TLR4; toll-like receptor 4 precursor [KO:K10160]
101799483  ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
101799536  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
101800437  ACTB; actin, cytoplasmic 1 [KO:K05692]
101800453  RAB7A; ras-related protein Rab-7a [KO:K07897]
101800609  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X5 [KO:K10415]
101800737  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101800759  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101800998  MRC1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
101801190  [KO:K06560]
101801296  COLEC12; collectin-12 isoform X2 [KO:K10062]
101801315  [KO:K10789] [EC:1.11.2.2]
101801330  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101801378  [KO:K06560]
101801619  THBS4; thrombospondin-4 isoform X2 [KO:K04659]
101801736  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101801980  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101802038  [KO:K07374]
101802167  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101802187  [KO:K07375]
101802508  ITGA2; integrin alpha-2 [KO:K06481]
101802575  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
101802582  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101803022  ITGAV; integrin alpha-V [KO:K06487]
101803068  TFRC; transferrin receptor protein 1 [KO:K06503]
101803099  TUBB6; tubulin beta-6 chain [KO:K07375]
101803168  CTSL; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
101803217  [KO:K06560]
101803244  [KO:K07375]
101803344  [KO:K04659]
101803666  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
101803871  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
101804125  [KO:K06752]
101804215  CANX; calnexin [KO:K08054]
101804425  [KO:K07374]
101804607  [KO:K07374]
101804861  MARCO; macrophage receptor MARCO isoform X2 [KO:K13884]
101804924  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
101805028  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101805041  [KO:K07374]
101805061  [KO:K10789] [EC:1.11.2.2]
101805143  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101805176  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
101805179  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
101805199  [KO:K06563]
101805438  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
106015064  [KO:K06560]
106019938  CALR3; calreticulin-3 [KO:K08057]
110351185  [KO:K10159]
113839605  [KO:K01365] [EC:3.4.22.15]
113840038  RAB5B; ras-related protein Rab-5B [KO:K07888]
113843982  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
113844802  TUBB3; tubulin beta-3 chain [KO:K07375]
119712955  [KO:K06856]
119713181  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
119713402  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
119713749  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
119714085  RAB5C; ras-related protein Rab-5C [KO:K07889]
119714717  [KO:K07374]
119714718  [KO:K07374]
119714790  TUBB; tubulin beta chain [KO:K07375]
119715003  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
119715062  [KO:K06752]
119715258  [KO:K06751]
119715301  [KO:K07374]
119715421  [KO:K10159]
119716567  [KO:K10066]
119717653  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
119718137  [KO:K08009]
119718656  [KO:K05654] [EC:7.4.2.14]
119718657  [KO:K05653] [EC:7.4.2.14]
119718678  [KO:K06752]
119718679  [KO:K06752]
119718708  [KO:K06752]
119718710  [KO:K06752]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
apla04142  Lysosome
apla04144  Endocytosis
apla04620  Toll-like receptor signaling pathway
KO pathway
ko04145   

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