Entry
Name
Phagosome - Anas platyrhynchos (mallard)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Anas platyrhynchos (mallard) [GN:
apla ]
Gene
101790497 class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751 ]
119715258 LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
119718679 HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752 ]
119715062 HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752 ]
119718678 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
119718708 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
119718710 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
101789604 class II histocompatibility antigen, B-L beta chain precursor [KO:K06752 ]
101799282 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
101805143 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
119715003 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
101799536 ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148 ]
101805176 ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154 ]
101799483 ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a2 [KO:K02154 ]
101801736 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
119717653 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
101801330 DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413 ]
101798656 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
101792180 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
101800609 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X5 [KO:K10415 ]
101797299 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
101798684 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
101804924 TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374 ]
101795466 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
101793156 SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956 ]
101805438 SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
101791910 SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342 ]
119712955 LOW QUALITY PROTEIN: immunoglobulin gamma-1 heavy chain-like [KO:K06856 ]
101797295 SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
101801980 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Related pathway
apla04620 Toll-like receptor signaling pathway
KO pathway
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