KEGG   PATHWAY: atd04013
Entry
atd04013                    Pathway                                
Name
MAPK signaling pathway - fly - Aethina tumida (small hive beetle)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
atd04013  MAPK signaling pathway - fly
atd04013

Other DBs
GO: 0000165
Organism
Aethina tumida (small hive beetle) [GN:atd]
Gene
109594971  torso-like protein isoform X1 [KO:K12377]
109596313  protein trunk [KO:K20226]
126265086  uncharacterized protein LOC126265086 [KO:K20226]
109595712  tyrosine-protein kinase receptor torso [KO:K12378] [EC:2.7.10.1]
109594704  protein giant-lens [KO:K02104]
109602936  protein vein isoform X1 [KO:K16690]
109605155  pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K16691]
109595878  epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
109599559  uncharacterized protein LOC109599559 [KO:K20230]
109594382  proto-oncogene tyrosine-protein kinase ROS [KO:K05088] [EC:2.7.10.1]
109601124  SHC-transforming protein 1 [KO:K06279]
109608829  growth factor receptor-bound protein 2 [KO:K04364]
109609395  GRB2-associated-binding protein 1 isoform X1 [KO:K20231]
109594310  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
109597854  protein son of sevenless [KO:K03099]
109604394  protein sprouty homolog 2 [KO:K17383]
109602915  ras-like protein 1 [KO:K07827]
109604552  ras GTPase-activating protein 1 [KO:K04352]
109596013  GTPase-activating protein [KO:K12380]
109597407  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
109597414  raf homolog serine/threonine-protein kinase Raf-like [KO:K04365] [EC:2.7.11.1]
109594907  14-3-3 protein zeta isoform X1 [KO:K16197]
109604044  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109601860  kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
109595060  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
109609505  dual specificity mitogen-activated protein kinase kinase dSOR1-like [KO:K04368] [EC:2.7.12.2]
109603469  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109601996  importin-7 isoform X1 [KO:K20223]
109595448  putative transcription factor capicua isoform X1 [KO:K20225]
109609065  nuclear receptor subfamily 2 group E member 1 isoform X2 [KO:K08545]
109599876  protein groucho isoform X1 [KO:K04497]
109604690  protein groucho isoform X1 [KO:K04497]
109597109  zinc finger and SCAN domain-containing protein 2 [KO:K12379]
109599424  ETS-like protein pointed isoform X1 [KO:K02678]
109603593  ets DNA-binding protein pokkuri isoform X1 [KO:K03211]
109600190  Friend leukemia integration 1 transcription factor isoform X1 [KO:K20232]
109593935  exportin-1 [KO:K14290]
109602044  protein tramtrack, alpha isoform isoform X1 [KO:K09237]
109597271  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
109596707  E3 ubiquitin-protein ligase sina isoform X1 [KO:K04506] [EC:2.3.2.27]
109597208  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
109601092  TNF receptor-associated factor family protein DDB_G0285149 [KO:K04506] [EC:2.3.2.27]
109596168  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
109597692  E3 ubiquitin-protein ligase siah-1 [KO:K04506] [EC:2.3.2.27]
109598097  E3 ubiquitin-protein ligase SIAH1A [KO:K04506] [EC:2.3.2.27]
109601960  uncharacterized protein LOC109601960 [KO:K04506] [EC:2.3.2.27]
109593889  uncharacterized protein LOC109593889 [KO:K04506] [EC:2.3.2.27]
109598822  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
109606331  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
109601589  uncharacterized protein LOC109601589 [KO:K04506] [EC:2.3.2.27]
109601105  E3 ubiquitin-protein ligase sina [KO:K04506] [EC:2.3.2.27]
109598289  uncharacterized protein LOC109598289 isoform X2 [KO:K04506] [EC:2.3.2.27]
126265302  E3 ubiquitin-protein ligase SIAH1B-like [KO:K04506] [EC:2.3.2.27]
126265566  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
126265583  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
126265685  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
109603975  F-box-like/WD repeat-containing protein TBL1XR1-A [KO:K04508]
109609097  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109596966  runt-related transcription factor 3 isoform X1 [KO:K20214]
109594223  homeobox protein prospero isoform X1 [KO:K20211]
109602307  tumor necrosis factor receptor superfamily member wengen isoform X1 [KO:K16679]
109599445  docking protein 2 [KO:K20234]
109604702  tyrosine-protein kinase SRK3 [KO:K05704] [EC:2.7.10.2]
109598793  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
109601140  tyrosine-protein kinase Shark [KO:K17512] [EC:2.7.10.2]
109605355  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K08840] [EC:2.7.11.1]
109598321  ras-like GTP-binding protein RhoL [KO:K04392]
109599988  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109605154  ras-related protein Rac1 [KO:K04392]
109596640  ras-like GTP-binding protein RhoL [KO:K04392]
109597958  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109601800  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
109596958  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
109596474  mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04417] [EC:2.7.11.25]
109608402  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
109600694  protein phosphatase 1A [KO:K04461] [EC:3.1.3.16]
109609105  dual specificity mitogen-activated protein kinase kinase hemipterous-like [KO:K04431] [EC:2.7.12.2]
109608868  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
109597490  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
109597963  striatin-3 isoform X1 [KO:K17608]
109593897  transcription factor JunD [KO:K04448]
109600708  transcription factor kayak isoform X1 [KO:K09031]
109605082  ras-responsive element-binding protein 1 [KO:K20210]
109606765  protein decapentaplegic [KO:K04662]
109598554  bone morphogenetic protein 4 isoform X2 [KO:K04662]
109594323  profilin [KO:K05759]
109605183  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
109594648  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
109606034  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
109600009  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
109608832  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04432] [EC:2.7.12.2]
109600802  mitogen-activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
109608283  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109594881  dual oxidase-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]
109594882  dual oxidase 2-like [KO:K13411] [EC:1.6.3.1 1.11.1.-]
109596781  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
109605634  optomotor-blind protein isoform X1 [KO:K10176]
109599633  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
109597980  superoxide dismutase [Mn] 1, mitochondrial [KO:K04564] [EC:1.15.1.1]
109604517  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
atd04214  Apoptosis - fly
KO pathway
ko04013   
LinkDB

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