KEGG   PATHWAY: bbub05165
Entry
bbub05165                   Pathway                                
Name
Human papillomavirus infection - Bubalus bubalis (water buffalo)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
bbub05165  Human papillomavirus infection
bbub05165

Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102403747  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102392459  WNT2; protein Wnt-2 [KO:K00182]
102401777  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
102413171  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
102410425  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
102405649  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102414969  WNT5B; protein Wnt-5b [KO:K00444]
102403744  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102407032  WNT6; protein Wnt-6 [KO:K00445]
102401643  WNT7B; protein Wnt-7b [KO:K00572]
102399122  WNT7A; protein Wnt-7a [KO:K00572]
102389510  WNT8A; protein Wnt-8a [KO:K00714]
102413228  WNT8B; protein Wnt-8b [KO:K00714]
102410973  WNT9A; protein Wnt-9a [KO:K01064]
102413713  WNT9B; protein Wnt-9b [KO:K01064]
102404088  WNT10B; protein Wnt-10b [KO:K01357]
102406713  WNT10A; protein Wnt-10a [KO:K01357]
102409223  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102404380  WNT16; protein Wnt-16 [KO:K01558]
102414897  FZD1; frizzled-1 [KO:K02432]
102390417  FZD7; frizzled-7 [KO:K02432]
123332452  FZD2; frizzled-2 [KO:K02235]
102398294  FZD3; frizzled-3 isoform X1 [KO:K02329]
102393665  FZD4; frizzled-4 [KO:K02354]
102404306  FZD8; frizzled-8 [KO:K02375]
102400404  FZD5; frizzled-5 [KO:K02375]
102403371  FZD6; frizzled-6 isoform X1 [KO:K02376]
102390891  FZD10; frizzled-10 [KO:K02842]
102399120  FZD9; frizzled-9 [KO:K02842]
102407432  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102400530  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X3 [KO:K02353]
102390581  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X7 [KO:K02353]
102401080  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
102394098  AXIN1; axin-1 isoform X1 [KO:K02157]
102388903  AXIN2; axin-2 [KO:K04385]
102413003  APC2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
102396874  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102396277  CTNNB1; catenin beta-1 [KO:K02105]
102403156  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
123331721  casein kinase I [KO:K08957] [EC:2.7.11.1]
102388955  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
102408996  TCF7; transcription factor 7 isoform X2 [KO:K02620]
102410081  TCF7L1; transcription factor 7-like 1 isoform X2 [KO:K04490]
102393101  TCF7L2; transcription factor 7-like 2 isoform X10 [KO:K04491]
102401427  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
102394367  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102402850  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102402262  TRAF3; TNF receptor-associated factor 3 isoform X2 [KO:K03174]
102398659  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
102403644  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
102396674  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112583883  interferon beta-3 [KO:K05415]
112583884  interferon beta-3 [KO:K05415]
112583885  interferon beta-3-like [KO:K05415]
112583886  interferon beta-3 [KO:K05415]
102402056  interferon beta-2 [KO:K05415]
102408434  interferon beta-3 [KO:K05415]
102402367  interferon beta-3-like [KO:K05415]
102402697  interferon beta-2 [KO:K05415]
123332785  interferon beta-3-like [KO:K05415]
123465588  interferon beta-3-like [KO:K05415]
123465589  interferon beta-3-like [KO:K05415]
102403750  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
102394197  EP300; histone acetyltransferase p300 isoform X4 [KO:K04498] [EC:2.3.1.48]
102392264  TADA3; transcriptional adapter 3 [KO:K11315]
102402069  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
102388975  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
102405361  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102400131  PARD3; partitioning defective 3 homolog isoform X22 [KO:K04237]
102401779  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102407423  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102394392  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102412595  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
102403175  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102403472  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102403055  SCRIB; protein scribble homolog isoform X3 [KO:K16175]
102396861  DLG1; disks large homolog 1 isoform X6 [KO:K12076]
102409056  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
102396743  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
102396001  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
102409446  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
102411976  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
102413518  protein crumbs homolog 3-like [KO:K06090]
102390184  PATJ; InaD-like protein isoform X2 [KO:K06092]
102410423  PALS1; protein PALS1 isoform X1 [KO:K06091]
102397126  VWF; von Willebrand factor [KO:K03900]
102401160  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
102402152  cartilage oligomeric matrix protein [KO:K04659]
102396797  THBS3; thrombospondin-3 [KO:K04659]
102398782  THBS4; thrombospondin-4 [KO:K04659]
102407341  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
102410593  FN1; fibronectin isoform X12 [KO:K05717]
102391895  COL1A1; collagen alpha-1(I) chain isoform X2 [KO:K06236]
102414428  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102403678  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
102416276  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
102389047  COL4A4; collagen alpha-4(IV) chain isoform X2 [KO:K06237]
102399306  COL4A5; collagen alpha-5(IV) chain isoform X5 [KO:K06237]
102403266  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102405654  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102410702  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
102397245  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102392465  COL6A3; collagen alpha-3(VI) chain isoform X9 [KO:K06238]
102389816  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
102394387  COL6A5; collagen alpha-5(VI) chain isoform X3 [KO:K06238]
102393741  collagen alpha-6(VI) chain isoform X2 [KO:K06238]
102391810  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain [KO:K06238]
102391279  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102400772  COL9A2; collagen alpha-2(IX) chain isoform X2 [KO:K08131]
123464893  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
102398304  LAMA1; laminin subunit alpha-1 [KO:K05637]
102413540  LAMA2; laminin subunit alpha-2 isoform X2 [KO:K05637]
102415747  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
102404504  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
102391381  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
102412743  LAMB1; laminin subunit beta-1 [KO:K05636]
102396042  laminin subunit beta-2 [KO:K06243]
102398665  laminin subunit beta-2 [KO:K06243]
102407847  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102412416  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
102393766  LAMC1; laminin subunit gamma-1 [KO:K05635]
102394621  LAMC2; laminin subunit gamma-2 [KO:K06246]
102409995  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
102393512  CHAD; chondroadherin [KO:K06248]
102412024  RELN; reelin [KO:K06249] [EC:3.4.21.-]
102403043  SPP1; osteopontin [KO:K06250]
102405652  VTN; vitronectin [KO:K06251]
102392969  TNR; tenascin-R isoform X1 [KO:K06252]
102414658  TNC; tenascin isoform X11 [KO:K06252]
102393925  TNXB; tenascin-X isoform X5 [KO:K06252]
102394894  TNN; tenascin-N isoform X3 [KO:K06252]
102402073  bone sialoprotein 2 isoform X1 [KO:K06253]
102411404  ITGA1; integrin alpha-1 [KO:K06480]
102412068  ITGA2; integrin alpha-2 [KO:K06481]
102401103  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102390332  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102405463  ITGA4; integrin alpha-4 isoform X3 [KO:K06483]
102404538  ITGA5; integrin alpha-5 [KO:K06484]
102415854  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102406242  ITGA7; integrin alpha-7 isoform X6 [KO:K06583]
102415655  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102401176  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102395549  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102393886  ITGA11; integrin alpha-11 [KO:K06587]
102406315  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
102401423  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102401695  LOW QUALITY PROTEIN: integrin beta-1-like [KO:K05719]
102391335  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102400042  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102398687  ITGB5; integrin beta-5 [KO:K06588]
102395168  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102396110  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
102411455  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102389136  PTK2; focal adhesion kinase 1 isoform X16 [KO:K05725] [EC:2.7.10.2]
102397491  PXN; paxillin isoform X2 [KO:K05760]
102392112  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102398200  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102416185  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102404535  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
102408756  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102397985  FADD; FAS-associated death domain protein [KO:K02373]
102412929  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102415768  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102411313  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
102398465  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102407460  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102396397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102409320  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
102412869  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102412546  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102392164  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102393986  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
102400472  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
102390645  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
102399525  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102399159  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
102414603  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102398540  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
102406434  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102412395  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102411610  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X22 [KO:K11584]
102414330  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
102401735  TSC1; hamartin isoform X2 [KO:K07206]
102389973  TSC2; tuberin isoform X10 [KO:K07207]
102410817  RHEB; GTP-binding protein Rheb isoform X3 [KO:K07208]
102407977  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112582961  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102402840  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X4 [KO:K04688] [EC:2.7.11.1]
102413442  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
102403948  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
102414298  BAD; bcl2-associated agonist of cell death [KO:K02158]
102392216  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102395384  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102396402  FOXO1; forkhead box protein O1 [KO:K07201]
102406138  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
102403077  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102411133  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102410004  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102412107  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102412787  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102407325  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
102390852  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
102389005  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
102398457  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
102400134  RB1; retinoblastoma-associated protein [KO:K06618]
102407397  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
102416097  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
102396902  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
123464883  E2F1; transcription factor E2F1 [KO:K17454]
102398715  CCNA2; cyclin-A2 [KO:K06627]
102408087  CCNA1; cyclin-A1 [KO:K06627]
102399207  ATM; serine-protein kinase ATM isoform X2 [KO:K04728] [EC:2.7.11.1]
102411932  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
102396324  VEGFA; vascular endothelial growth factor A [KO:K05448]
102399613  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
102398886  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102394706  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
102403930  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102397938  RELA; transcription factor P65 [KO:K04735]
102401535  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
102391587  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
102407100  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102400806  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
123465664  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X6 [KO:K11643] [EC:5.6.2.-]
102398631  IRF1; interferon regulatory factor 1 isoform X2 [KO:K09444]
102394310  TBPL2; TATA box-binding protein-like 2 isoform X1 [KO:K03120]
102395512  TATA-box-binding protein [KO:K03120]
102407125  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
102408938  TATA-box-binding protein-like isoform X2 [KO:K03120]
102393680  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102394332  BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
102410916  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X3 [KO:K06751]
102412769  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X3 [KO:K06751]
102394968  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102390435  BOLA class I histocompatibility antigen, alpha chain BL3-6 isoform X1 [KO:K06751]
102398125  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X2 [KO:K06751]
102402481  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
102413969  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102392615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
102406719  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102412126  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102414483  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
102410690  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102409602  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102402950  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
102413011  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
102397436  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X2 [KO:K02148]
102409973  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102401682  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
102405483  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102401571  LOW QUALITY PROTEIN: V-type proton ATPase subunit E 1-like [KO:K02150]
102397284  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102394169  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
102389329  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102412274  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102413133  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102396288  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
102408292  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
102403479  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
102413360  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X7 [KO:K02154]
102407192  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
102405239  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
102416513  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
102411839  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
102400266  V-type proton ATPase subunit e 1-like [KO:K02153]
102408971  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102408343  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
102398941  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102416325  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102398103  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102394713  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102412823  SOS2; son of sevenless homolog 2 [KO:K03099]
102392913  SOS1; son of sevenless homolog 1 isoform X3 [KO:K03099]
112587129  GTPase HRas-like [KO:K02833]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102416528  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102405821  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102408597  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112577614  neuroendocrine secretory protein 55 [KO:K04632]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102400076  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102401906  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102406078  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
102395032  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
102400784  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102416630  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102398301  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
102400864  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
102411218  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
102409608  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
102409942  tubulin gamma-1 chain [KO:K10389]
102415788  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
102393818  interferon alpha-H-like [KO:K05414]
102393701  interferon alpha-F [KO:K05414]
112583867  interferon alpha-H-like [KO:K05414]
102416204  interferon alpha-H [KO:K05414]
102402789  interferon alpha-H-like [KO:K05414]
112583876  interferon alpha-H-like [KO:K05414]
112583880  interferon alpha-B [KO:K05414]
102415114  interferon alpha-B-like [KO:K05414]
102414434  interferon alpha-H [KO:K05414]
112583541  interferon alpha-H [KO:K05414]
112577736  interferon alpha-H-like [KO:K05414]
112583544  interferon alpha-H [KO:K05414]
112583546  interferon alpha-H [KO:K05414]
112583548  interferon alpha-H-like [KO:K05414]
112583545  interferon alpha-B-like [KO:K05414]
102394317  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102394946  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102405285  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102402213  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
102415500  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
102414314  STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221]
102395411  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102391649  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
102389199  OASL; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
102399772  MX1; interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
102399001  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
102401758  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
102397271  JAG1; protein jagged-1 isoform X1 [KO:K06052]
102415149  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
102410459  NOTCH2; neurogenic locus notch homolog protein 2 isoform X3 [KO:K20994]
102412196  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
102400757  NOTCH4; neurogenic locus notch homolog protein 4 isoform X3 [KO:K20996]
102395946  PSEN1; presenilin-1 isoform X4 [KO:K04505] [EC:3.4.23.-]
102410037  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
102415597  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
102394903  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X2 [KO:K05948] [EC:2.4.1.222]
102414338  MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]
102408189  MAML3; mastermind-like protein 3 isoform X2 [KO:K06061]
102397801  MAML2; mastermind-like protein 2 isoform X2 [KO:K06061]
102415975  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
123464875  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
102389836  HES1; transcription factor HES-1 [KO:K06054]
102406522  HES6; transcription cofactor HES-6 isoform X2 [KO:K09087]
102396290  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
102392577  HES2; transcription factor HES-2 isoform X2 [KO:K09087]
123465789  HES4; transcription factor HES-4 isoform X2 [KO:K09089]
102399494  HES5; transcription factor HES-5 [KO:K06055]
102416146  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
102409730  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
102393583  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X4 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20592731
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:26008697
  Authors
Tummers B, Burg SH
  Title
High-risk human papillomavirus targets crossroads in immune signaling.
  Journal
Viruses 7:2485-506 (2015)
DOI:10.3390/v7052485
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
Reference
PMID:23164805
  Authors
Pang CL, Thierry F
  Title
Human papillomavirus proteins as prospective therapeutic targets.
  Journal
Microb Pathog 58:55-65 (2013)
DOI:10.1016/j.micpath.2012.11.002
Reference
PMID:19156753
  Authors
Yugawa T, Kiyono T
  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
  Journal
Rev Med Virol 19:97-113 (2009)
DOI:10.1002/rmv.605
Reference
PMID:17645777
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
PMID:11486705
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
Reference
PMID:10793105
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
PMID:16259056
  Authors
Kim YT, Zhao M
  Title
Aberrant cell cycle regulation in cervical carcinoma.
  Journal
Yonsei Med J 46:597-613 (2005)
DOI:10.3349/ymj.2005.46.5.597
Reference
PMID:15956361
  Authors
McCance DJ
  Title
Human papillomaviruses and cell signaling.
  Journal
Sci STKE 2005:pe29 (2005)
DOI:10.1126/stke.2882005pe29
Reference
PMID:15342967
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
  Authors
Tommasino M
  Title
The human papillomavirus family and its role in carcinogenesis.
  Journal
Semin Cancer Biol 26:13-21 (2014)
DOI:10.1016/j.semcancer.2013.11.002
Reference
PMID:26295406
  Authors
Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
  Title
Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
  Journal
Viruses 7:4734-55 (2015)
DOI:10.3390/v7082842
Reference
PMID:26289783
  Authors
Shah M, Anwar MA, Park S, Jafri SS, Choi S
  Title
In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
  Journal
Sci Rep 5:13446 (2015)
DOI:10.1038/srep13446
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26147797
  Authors
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
  Journal
Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
  Authors
Banks L, Pim D, Thomas M
  Title
Human tumour viruses and the deregulation of cell polarity in cancer.
  Journal
Nat Rev Cancer 12:877-86 (2012)
DOI:10.1038/nrc3400
Reference
PMID:19029942
  Authors
Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
  Title
Human papillomaviruses, cervical cancer and cell polarity.
  Journal
Oncogene 27:7018-30 (2008)
DOI:10.1038/onc.2008.351
Reference
PMID:19901438
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
PMID:16862386
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
PMID:26022660
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
Reference
PMID:11753669
  Authors
DiMaio D, Mattoon D
  Title
Mechanisms of cell transformation by papillomavirus E5 proteins.
  Journal
Oncogene 20:7866-73 (2001)
DOI:10.1038/sj.onc.1204915
Reference
PMID:22262402
  Authors
Ganguly N
  Title
Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
  Journal
Cell Oncol (Dordr) 35:67-76 (2012)
DOI:10.1007/s13402-011-0069-x
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:23403708
  Authors
De Marco F
  Title
Oxidative stress and HPV carcinogenesis.
  Journal
Viruses 5:708-31 (2013)
DOI:10.3390/v5020708
Reference
PMID:26643553
  Authors
Wieringa HW, van der Zee AG, de Vries EG, van Vugt MA
  Title
Breaking the DNA damage response to improve cervical cancer treatment.
  Journal
Cancer Treat Rev 42:30-40 (2016)
DOI:10.1016/j.ctrv.2015.11.008
Reference
PMID:19861444
  Authors
Chung CH, Gillison ML
  Title
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
  Journal
Clin Cancer Res 15:6758-62 (2009)
DOI:10.1158/1078-0432.CCR-09-0784
Reference
PMID:11325599
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
PMID:10702232
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
PMID:22499770
  Authors
Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
  Title
Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
  Journal
Mol Cell Proteomics 11:M112.016998 (2012)
DOI:10.1074/mcp.M112.016998
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
  Journal
J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
bbub04064  NF-kappa B signaling pathway
bbub04110  Cell cycle
bbub04115  p53 signaling pathway
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04210  Apoptosis
bbub04310  Wnt signaling pathway
bbub04330  Notch signaling pathway
bbub04510  Focal adhesion
bbub04520  Adherens junction
bbub04530  Tight junction
bbub04612  Antigen processing and presentation
bbub04620  Toll-like receptor signaling pathway
bbub04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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