KEGG   PATHWAY: bmaz00260
Entry
bmaz00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia mallei NCTC 10247
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmaz00260  Glycine, serine and threonine metabolism
bmaz00260

Module
bmaz_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmaz00260]
bmaz_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmaz00260]
bmaz_M00555  Betaine biosynthesis, choline => betaine [PATH:bmaz00260]
bmaz_M00621  Glycine cleavage system [PATH:bmaz00260]
bmaz_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bmaz00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia mallei NCTC 10247 [GN:bmaz]
Gene
BM44_1713  aspartate kinase domain protein [KO:K00928] [EC:2.7.2.4]
BM44_3238  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BM44_1955  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BM44_3389  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BM44_1956  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BM44_3909  ltaE; low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BM44_1275  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
BM44_4014  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
BM44_1380  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BM44_1879  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
BM44_499  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BM44_775  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
BM44_937  putative d-3-phosphoglycerate dehydrogenase oxidoreductase protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BM44_1736  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BM44_2794  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BM44_2020  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BM44_1274  ydfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BM44_3654  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BM44_3653  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BM44_298  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BM44_296  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BM44_2085  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM44_3748  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM44_1651  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BM44_297  gcvH; glycine cleavage system H protein [KO:K02437]
BM44_2610  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BM44_4500  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BM44_4499  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BM44_4021  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
BM44_4022  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
BM44_4017  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
BM44_4018  4Fe-4S dicluster domain protein [KO:K21834]
BM44_4019  electron transfer flavodomain protein [KO:K25960]
BM44_4020  electron transfer flavodomain protein [KO:K25961]
BM44_4515  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BM44_4514  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BM44_300  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BM44_4407  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BM44_4411  pyridoxal-phosphate dependent enzyme family protein [KO:K01754] [EC:4.3.1.19]
BM44_1854  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
BM44_896  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BM44_901  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
BM44_3321  pyridoxal-phosphate dependent enzyme family protein [KO:K01753] [EC:4.3.1.18]
BM44_3322  putative d-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BM44_3232  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BM44_3234  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BM44_444  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
BM44_3165  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmaz00010  Glycolysis / Gluconeogenesis
bmaz00020  Citrate cycle (TCA cycle)
bmaz00230  Purine metabolism
bmaz00250  Alanine, aspartate and glutamate metabolism
bmaz00270  Cysteine and methionine metabolism
bmaz00290  Valine, leucine and isoleucine biosynthesis
bmaz00300  Lysine biosynthesis
bmaz00330  Arginine and proline metabolism
bmaz00460  Cyanoamino acid metabolism
bmaz00470  D-Amino acid metabolism
bmaz00564  Glycerophospholipid metabolism
bmaz00600  Sphingolipid metabolism
bmaz00620  Pyruvate metabolism
bmaz00630  Glyoxylate and dicarboxylate metabolism
bmaz00640  Propanoate metabolism
bmaz00680  Methane metabolism
bmaz00860  Porphyrin metabolism
bmaz00920  Sulfur metabolism
KO pathway
ko00260   
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