KEGG   PATHWAY: bom05163
Entry
bom05163                    Pathway                                
Name
Human cytomegalovirus infection - Bos mutus (wild yak)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
bom05163  Human cytomegalovirus infection
bom05163

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102282598  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102275199  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102265427  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102283212  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102280709  TSC1; tuberous sclerosis 1 [KO:K07206]
102267343  TSC2; tuberous sclerosis 2 [KO:K07207]
102277658  RHEB; Ras homolog enriched in brain [KO:K07208]
102267219  GTP-binding protein Rheb [KO:K07208]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102278368  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102285710  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102271079  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102281886  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102281443  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102287968  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102286969  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102268417  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102269868  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102286241  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102286943  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102277585  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102286500  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102269203  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102280670  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102271710  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102286114  ELK1; ELK1, ETS transcription factor [KO:K04375]
102282294  SP1; Sp1 transcription factor [KO:K04684]
102281111  ITGAV; integrin subunit alpha V [KO:K06487]
102268918  ITGB3; integrin subunit beta 3 [KO:K06493]
102284506  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102273253  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102277352  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102286986  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102280554  RHOA; ras homolog family member A [KO:K04513]
102285090  MB21D1; Mab-21 domain containing 1 [KO:K17834] [EC:2.7.7.86]
102280504  TMEM173; transmembrane protein 173 [KO:K12654]
102279479  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102279593  IRF3; interferon regulatory factor 3 [KO:K05411]
102266354  interferon alpha-1 [KO:K05414]
102267307  interferon alpha-B [KO:K05414]
102270981  interferon alpha-H [KO:K05414]
102286313  interferon alpha-A [KO:K05414]
102281344  interferon alpha-2 [KO:K05414]
102267762  interferon alpha-F [KO:K05414]
102285417  interferon alpha-H-like [KO:K05414]
102284581  interferon beta-2 [KO:K05415]
102282466  interferon beta-2 [KO:K05415]
102281065  interferon beta-2 [KO:K05415]
102280497  interferon beta-2 [KO:K05415]
102277911  TNF; tumor necrosis factor [KO:K03156]
102285873  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102279783  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
102273045  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102266053  TRAF5; TNF receptor associated factor 5 [KO:K09849]
102275265  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102282890  IL1B; interleukin 1 beta [KO:K04519]
102271047  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
102275402  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102271913  CCL2; C-C motif chemokine 2 [KO:K14624]
102264969  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
102268124  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
102287919  IL6; interleukin 6 [KO:K05405]
102270539  GNB1; G protein subunit beta 1 [KO:K04536]
102272842  GNB2; G protein subunit beta 2 [KO:K04537]
102281665  GNB3; G protein subunit beta 3 [KO:K07825]
102275603  GNB4; G protein subunit beta 4 [KO:K04538]
102273730  GNB5; G protein subunit beta 5 [KO:K04539]
102266170  GNG2; G protein subunit gamma 2 [KO:K07826]
102271562  GNG3; G protein subunit gamma 3 [KO:K04540]
102279686  GNG4; G protein subunit gamma 4 [KO:K04541]
102266890  GNG5; G protein subunit gamma 5 [KO:K04542]
102269855  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102266700  GNG7; G protein subunit gamma 7 [KO:K04543]
106701100  GNG8; G protein subunit gamma 8 [KO:K04544]
106701364  GNG10; G protein subunit gamma 10 [KO:K04545]
102266636  GNG11; G protein subunit gamma 11 [KO:K04546]
102271265  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102287427  GNG12; G protein subunit gamma 12 [KO:K04347]
102287565  GNG13; G protein subunit gamma 13 [KO:K04547]
102266141  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
102270926  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102287414  GNAQ; G protein subunit alpha q [KO:K04634]
102287661  GNA11; G protein subunit alpha 11 [KO:K04635]
102264989  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102278948  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102273347  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102276260  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102269088  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102269013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102271039  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102280361  calmodulin-alpha [KO:K02183]
102285968  CALML6; calmodulin like 6 [KO:K02183]
102281667  CALM1; calmodulin 1 [KO:K02183]
102287375  calmodulin [KO:K02183]
102268061  CALM2; calmodulin 2 [KO:K02183]
102265605  calmodulin-alpha [KO:K02183]
102266295  calmodulin [KO:K02183]
102282476  CALM3; calmodulin 3 [KO:K02183]
102269657  CALML3; calmodulin-like protein 3 [KO:K02183]
102271961  calmodulin-2/4-like [KO:K02183]
102284406  CALML4; calmodulin like 4 [KO:K02183]
102275863  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102286752  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102266749  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102272271  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102277736  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102286049  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102285474  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
102277605  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
102281905  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102285411  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
102271174  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102285228  GNAI3; G protein subunit alpha i3 [KO:K04630]
102274651  GNAI2; G protein subunit alpha i2 [KO:K04630]
102273920  GNAI1; G protein subunit alpha i1 [KO:K04630]
102280695  GNAO1; G protein subunit alpha o1 [KO:K04534]
102267116  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102274117  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102282732  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102286168  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102276460  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102265325  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102266966  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102272964  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102285642  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102281757  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102269124  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102272762  C-C motif chemokine 3 [KO:K05408]
102287625  CCL3; C-C motif chemokine 3 [KO:K05408]
102287335  CCL4; C-C motif chemokine 4 [KO:K12964]
102270401  CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
102265273  GNA12; G protein subunit alpha 12 [KO:K04346]
102275435  GNA13; G protein subunit alpha 13 [KO:K04639]
102271873  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
102265611  ARHGEF11; Rho guanine nucleotide exchange factor 11 [KO:K12331]
102277776  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102286418  AKAP13; A-kinase anchoring protein 13 [KO:K16529]
102284712  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102267122  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102275011  CTNNB1; catenin beta 1 [KO:K02105]
102286523  PTGER1; prostaglandin E receptor 1 [KO:K04258]
102286394  PTGER2; prostaglandin E receptor 2 [KO:K04259]
102277668  PTGER3; prostaglandin E receptor 3 [KO:K04260]
102269417  PTGER4; prostaglandin E receptor 4 [KO:K04261]
102266153  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
102286123  neuroendocrine secretory protein 55 [KO:K04632]
102275260  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102270546  CCND1; cyclin D1 [KO:K04503]
102274304  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102287439  IL6R; interleukin 6 receptor [KO:K05055]
102286137  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
102282282  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102270607  VEGFA; vascular endothelial growth factor A [KO:K05448]
102272962  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102271030  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102271320  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
106701244  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102285848  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102281756  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102283891  ATF2; activating transcription factor 2 [KO:K04450]
102267423  ATF4; activating transcription factor 4 [KO:K04374]
102281505  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102268154  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102264680  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102271999  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102277321  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102275204  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102288212  ATF6B; activating transcription factor 6 beta [KO:K09049]
102275373  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102280853  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102278724  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102274116  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102265831  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102266592  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
102280095  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102286652  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
102277025  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102275497  PXN; paxillin [KO:K05760]
102274768  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
102275508  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
102269514  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
102287450  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102288017  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
102264498  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102269065  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653] [EC:7.4.2.14]
102283284  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654] [EC:7.4.2.14]
102264737  TAPBP; TAP binding protein [KO:K08058]
102281691  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
102275440  CALR; calreticulin [KO:K08057]
102282354  calreticulin-like [KO:K08057]
102288356  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
102275624  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
102268170  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102278231  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102286220  BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
102286791  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102281193  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102272326  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
102270654  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
102271983  B2M; beta-2-microglobulin [KO:K08055]
102284461  CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621]
102287490  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102272370  TP53; tumor protein p53 [KO:K04451]
102268672  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102278545  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102264992  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102267169  RB1; RB transcriptional corepressor 1 [KO:K06618]
102274863  E2F1; E2F transcription factor 1 [KO:K17454]
102268181  E2F2; E2F transcription factor 2 [KO:K09389]
102270876  E2F3; E2F transcription factor 3 [KO:K06620]
102281889  FASLG; Fas ligand [KO:K04389]
102273906  FAS; Fas cell surface death receptor [KO:K04390]
102271962  FADD; Fas associated via death domain [KO:K02373]
102272602  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102279560  BID; BH3 interacting domain death agonist [KO:K04726]
102279740  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102266544  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102276866  cytochrome c [KO:K08738]
102277261  cytochrome c [KO:K08738]
102277620  cytochrome c [KO:K08738]
106700494  cytochrome c 2 [KO:K08738]
102268660  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102287348  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
PMID:23145028
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
PMID:15990176
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
PMID:25549333
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
PMID:24445563
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:20398729
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
PMID:11175803
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
PMID:16352349
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
PMID:25805993
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
PMID:15172446
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
PMID:29237840
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:22454101
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
PMID:17145306
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
PMID:10707064
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
PMID:15389728
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
PMID:14975530
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
PMID:12062798
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
PMID:15352160
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
PMID:20969904
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
PMID:28869497
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
PMID:27160907
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
PMID:28488292
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
bom00590  Arachidonic acid metabolism
bom03050  Proteasome
bom04010  MAPK signaling pathway
bom04064  NF-kappa B signaling pathway
bom04110  Cell cycle
bom04150  mTOR signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04210  Apoptosis
bom04612  Antigen processing and presentation
bom04623  Cytosolic DNA-sensing pathway
bom04630  JAK-STAT signaling pathway
bom04668  TNF signaling pathway
bom04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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