KEGG   PATHWAY: cann03015
Entry
cann03015                   Pathway                                
Name
mRNA surveillance pathway - Capsicum annuum (peppers)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
cann03015  mRNA surveillance pathway
cann03015

Other DBs
GO: 0071028
Organism
Capsicum annuum (peppers) [GN:cann]
Gene
107845400  nuclear cap-binding protein subunit 1 [KO:K12882]
107858517  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
107839859  regulator of nonsense transcripts UPF3 [KO:K14328]
107872794  RNA-binding protein Y14A [KO:K12876]
107867828  RNA-binding protein Y14A [KO:K12876]
107846514  LOW QUALITY PROTEIN: RNA-binding protein Y14A-like [KO:K12876]
107858589  protein mago nashi homolog [KO:K12877]
107853881  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
107852527  histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
107839979  pinin [KO:K13114]
107867564  uncharacterized protein LOC107867564 [KO:K12875]
107867565  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
107845503  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
107870500  THO complex subunit 4D isoform X1 [KO:K12881]
107855748  THO complex subunit 4A [KO:K12881]
107870140  THO complex subunit 4D [KO:K12881]
107873264  THO complex subunit 4A [KO:K12881]
107843339  THO complex subunit 4A [KO:K12881]
107843389  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
107852648  mRNA export factor GLE1 isoform X1 [KO:K18723]
107872847  DEAD-box ATP-dependent RNA helicase 15 [KO:K12812] [EC:5.6.2.7]
107838872  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
107873253  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
107839969  partner of Y14 and mago [KO:K14294]
107842644  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
107847477  mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
107842586  mRNA cap guanine-N7 methyltransferase 1 [KO:K00565] [EC:2.1.1.56]
107862120  mRNA cap guanine-N7 methyltransferase 1 [KO:K00565] [EC:2.1.1.56]
107851101  mRNA cap guanine-N7 methyltransferase 2 isoform X1 [KO:K00565] [EC:2.1.1.56]
107875449  transcription initiation factor TFIID subunit 15b [KO:K13098]
107873586  transcription initiation factor TFIID subunit 15b [KO:K13098]
107852671  polyadenylate-binding protein 2 isoform X5 [KO:K14396]
107863557  polyadenylate-binding protein 1 [KO:K14396]
107850309  polyadenylate-binding protein 3 isoform X1 [KO:K14396]
107855654  pre-mRNA cleavage factor Im 25 kDa subunit 2 isoform X1 [KO:K14397]
107862663  pre-mRNA cleavage factor Im 25 kDa subunit 1 isoform X2 [KO:K14397]
107863303  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
124885421  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
107876942  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
107847666  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
107847812  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
107876108  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
107849800  nuclear poly(A) polymerase 3 [KO:K14376] [EC:2.7.7.19]
107847557  nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
107850323  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
107875978  protein CLP1 homolog isoform X2 [KO:K14399] [EC:2.7.1.78]
107850753  polyadenylation and cleavage factor homolog 4 [KO:K14400]
107843195  polyadenylation and cleavage factor homolog 4 [KO:K14400]
107843643  polyadenylation and cleavage factor homolog 4 [KO:K14400]
107863382  cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
107863270  cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
107859345  cleavage and polyadenylation specificity factor subunit 3-I isoform X1 [KO:K14403] [EC:3.1.27.-]
107876705  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
107839390  uncharacterized protein LOC107839390 isoform X1 [KO:K14404]
107859070  30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
107839054  flowering time control protein FY isoform X1 [KO:K15542]
107867936  protein ANTHESIS POMOTING FACTOR 1 isoform X1 [KO:K14962]
107859884  protein ANTHESIS POMOTING FACTOR 1 isoform X1 [KO:K14962]
107853425  serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
107859171  serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
107871357  serine/threonine-protein phosphatase PP1 isoform X2 [KO:K06269] [EC:3.1.3.16]
107873196  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
107873485  serine/threonine-protein phosphatase PP1 isozyme 1 [KO:K06269] [EC:3.1.3.16]
107875517  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
107839633  serine/threonine-protein phosphatase PP1 isozyme 9 [KO:K06269] [EC:3.1.3.16]
107862849  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
107850821  cleavage stimulation factor subunit 50 isoform X1 [KO:K14406]
107862553  cleavage stimulating factor 64 isoform X1 [KO:K14407]
107858958  LOW QUALITY PROTEIN: cleavage stimulating factor 64 [KO:K14407]
107840215  cleavage stimulation factor subunit 77 isoform X1 [KO:K14408]
107842598  uncharacterized protein LOC107842598 isoform X1 [KO:K06100]
107867321  symplekin [KO:K06100]
107864245  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107854016  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107860296  RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
107870112  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107863623  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107866370  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
107878162  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107845454  heterogeneous nuclear ribonucleoprotein 1 isoform X1 [KO:K14411]
107850914  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107860967  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107867265  RNA-binding protein 1 [KO:K14411]
107868445  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
107855601  polyadenylate-binding protein 3 [KO:K13126]
107843156  polyadenylate-binding protein 7 [KO:K13126]
107840253  polyadenylate-binding protein 8 isoform X1 [KO:K13126]
107850513  polyadenylate-binding protein 2 isoform X1 [KO:K13126]
107843391  polyadenylate-binding protein 7 isoform X1 [KO:K13126]
107854233  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
107871367  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
107850618  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
107840853  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
107861910  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
107855415  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
107847405  regulator of nonsense transcripts UPF2 isoform X1 [KO:K14327]
107840365  uncharacterized protein LOC107840365 [KO:K08873] [EC:2.7.11.1]
107843779  LOW QUALITY PROTEIN: nonsense-mediated mRNA decay factor SMG7 [KO:K14409]
107870817  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
107878033  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
107843392  serine/threonine-protein phosphatase PP2A-5 catalytic subunit [KO:K04382] [EC:3.1.3.16]
107873814  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
107867406  serine/threonine-protein phosphatase PP2A-2 catalytic subunit isoform X1 [KO:K04382] [EC:3.1.3.16]
107847727  serine/threonine-protein phosphatase PP2A-2 catalytic subunit isoform X1 [KO:K04382] [EC:3.1.3.16]
107855417  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
107847746  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
107865830  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
107854357  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
107861751  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
107875901  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
107850911  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
107870277  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
107871351  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
107842620  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
107839160  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
107871436  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
107858834  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform isoform X1 [KO:K11584]
107878168  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform [KO:K11584]
107847874  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
107868490  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform [KO:K11584]
107841759  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
107860727  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
107843140  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform isoform X1 [KO:K11584]
107840594  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
107843589  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
107862188  HBS1-like protein isoform X1 [KO:K14416]
107870304  protein PELOTA 1 isoform X3 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
cann03013  Nucleocytoplasmic transport
cann03018  RNA degradation
cann03040  Spliceosome
KO pathway
ko03015   
LinkDB

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