Entry
Name
Basal cell carcinoma - Castor canadensis (American beaver)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
BRITE hierarchy
Pathway map
Ortholog table
Organism
Castor canadensis (American beaver) [GN:
ccan ]
Gene
109691045 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
109696612 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402 ]
109698312 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
109674455 Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
109681149 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
109694105 Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
109691007 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
Compound
Reference
Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
Journal
Reference
Authors
Saldanha G, Fletcher A, Slater DN.
Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
Journal
Reference
Authors
Daya-Grosjean L, Couve-Privat S.
Title
Sonic hedgehog signaling in basal cell carcinomas.
Journal
Reference
Authors
Tsai KY, Tsao H.
Title
The genetics of skin cancer.
Journal
Reference
Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
Title
Hedgehog signalling in skin development and cancer.
Journal
Reference
Authors
Rubin AI, Chen EH, Ratner D.
Title
Basal-cell carcinoma.
Journal
Reference
Authors
Saldanha G.
Title
The Hedgehog signalling pathway and cancer.
Journal
Reference
Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
Journal
Reference
Authors
Pasca di Magliano M, Hebrok M.
Title
Hedgehog signalling in cancer formation and maintenance.
Journal
Reference
Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
Journal
Reference
Authors
Cohen MM Jr.
Title
The hedgehog signaling network.
Journal
Reference
Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
Journal
Reference
Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
Journal
Reference
Authors
Toftgard R.
Title
Hedgehog signalling in cancer.
Journal
Reference
Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Journal
Reference
Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
Title
Hedgehog signaling in basal cell carcinoma.
Journal
Related pathway
KO pathway
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